INT68681

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Context Info
Confidence 0.71
First Reported 1997
Last Reported 2011
Negated 1
Speculated 4
Reported most in Body
Documents 132
Total Number 137
Disease Relevance 80.47
Pain Relevance 17.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
endothelial cell 4
myocardium 3
platelet 3
cardiac myocytes 3
inner ear 3
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 138 100.00 Very High Very High Very High
chemokine 29 100.00 Very High Very High Very High
COX2 23 100.00 Very High Very High Very High
calcitonin gene related peptide 3 100.00 Very High Very High Very High
agonist 279 99.44 Very High Very High Very High
Pain 145 99.42 Very High Very High Very High
Inflammation 345 99.04 Very High Very High Very High
cytokine 200 98.88 Very High Very High Very High
palliative 100 98.84 Very High Very High Very High
ischemia 96 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 365 100.00 Very High Very High Very High
Ectopic Pregnancy 95 99.96 Very High Very High Very High
Bursitis 13 99.88 Very High Very High Very High
Glioma 95 99.86 Very High Very High Very High
Respiratory Syncytial Virus 200 99.84 Very High Very High Very High
Cancer 2036 99.82 Very High Very High Very High
Sprains And Strains 69 99.70 Very High Very High Very High
Diabetes Mellitus 1069 99.68 Very High Very High Very High
Hepatocellular Cancer 126 99.48 Very High Very High Very High
Necrosis 51 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a co-culture system comprised of murine peritoneal macrophages and intervertebral disc tissue as a model of the acute phase of HD developed previously, an increase in macrophage VEGF protein and mRNA expression was observed upon exposure to disc tissue.
Transcription (expression) of VEGF protein in macrophage associated with intervertebral disk displacement
1) Confidence 0.71 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12038611 Disease Relevance 0.96 Pain Relevance 0.28
Hypoxia-induced transcription of VEGF mRNA is mediated by binding of hypoxia-inducible factor 1 (HIF-1) [7].
Transcription (transcription) of VEGF associated with hypoxia
2) Confidence 0.70 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.36 Pain Relevance 0.05
We observed no significant deviation from the untreated mRNA levels for VEGF and bFGF during a 48 hour period after treatment with glucose alone or in combination with fluvastatin.
Transcription (levels) of VEGF
3) Confidence 0.69 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.38 Pain Relevance 0.16
Our study revealed a striking restriction of VEGF and bFGF mRNA expression in the diabetic sub-group of the atherosclerosis patient group with stable angina pectoris while the non diabetic sub-group displayed levels similar to the normal group.
Transcription (expression) of VEGF associated with stable angina pectoris, angina, atherosclerosis and diabetes mellitus
4) Confidence 0.69 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.65 Pain Relevance 0.38
To determine the effect of fluvastatin on the mRNA expression of bFGF and VEGF in monocytes of a healthy donor we performed kinetic analysis.
Transcription (expression) of VEGF in monocytes
5) Confidence 0.69 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.30 Pain Relevance 0
Real time reverse transcriptase polymerase chain reaction showed that morphine treatment (100 ng/ml) of hypoxic HUVECs resulted in a significant reduction in mRNA levels of VEGF(121) and VEGF(165) isoforms.
Transcription (levels) of VEGF associated with hypoxia and morphine
6) Confidence 0.69 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.77 Pain Relevance 1.01
Real time reverse transcriptase polymerase chain reaction showed that morphine treatment (100 ng/ml) of hypoxic HUVECs resulted in a significant reduction in mRNA levels of VEGF(121) and VEGF(165) isoforms.
Transcription (levels) of VEGF associated with hypoxia and morphine
7) Confidence 0.69 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.77 Pain Relevance 1.02
The intra assay variability of the mRNA measurements of our in vitro short term culture system was assessed by measuring the VEGF and bFGF mRNA in triplicate cultures each.
Transcription (measuring) of VEGF
8) Confidence 0.66 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.90 Pain Relevance 0.13
Quantitation of the mRNA for VEGF, bFGF and TGF-?
Transcription (mRNA) of VEGF
9) Confidence 0.66 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.39 Pain Relevance 0.21
Quantitation of the mRNA for VEGF, bFGF and TGF-?
Transcription (Quantitation) of VEGF
10) Confidence 0.66 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 1.40 Pain Relevance 0.22
Furthermore we analyzed in the above model the effect of high glucose levels found in diabetic individuals and statins found in the medication of all our patients on the mRNA levels of VEGF and bFGF during a 48 hour period.
Transcription (levels) of VEGF associated with diabetes mellitus
11) Confidence 0.66 Published 2003 Journal J Transl Med Section Body Doc Link PMC239962 Disease Relevance 0.60 Pain Relevance 0.05
Although both forms of the disease exhibited high levels of angiogenic activity, inflammatory breast cancer showed significantly higher mRNA expression of angiogenic and lymphangiogenic genes, including those encoding for VEGF-C and VEGF-D.
Transcription (expression) of VEGF associated with inflammation and disease
12) Confidence 0.63 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.33 Pain Relevance 0.19
Although both forms of the disease exhibited high levels of angiogenic activity, inflammatory breast cancer showed significantly higher mRNA expression of angiogenic and lymphangiogenic genes, including those encoding for VEGF-C and VEGF-D.
Transcription (expression) of VEGF associated with inflammation and disease
13) Confidence 0.63 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 1.33 Pain Relevance 0.19
One such example involves hypoxia-inducible factor-1, a transcription factor that regulates the expression of many angiogenesis- and glucose metabolism-related genes and in addition activates the transcription of VEGF in malignant gliomas.38,39 VEGF mRNA expression, as well as VEGF receptor expression, are well documented hypoxic induced changes in malignant gliomas.40
Transcription (transcription) of VEGF associated with hypoxia and glioma
14) Confidence 0.61 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895775 Disease Relevance 1.06 Pain Relevance 0.08
One such example involves hypoxia-inducible factor-1, a transcription factor that regulates the expression of many angiogenesis- and glucose metabolism-related genes and in addition activates the transcription of VEGF in malignant gliomas.38,39 VEGF mRNA expression, as well as VEGF receptor expression, are well documented hypoxic induced changes in malignant gliomas.40
Transcription (expression) of VEGF associated with hypoxia and glioma
15) Confidence 0.61 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2895775 Disease Relevance 0.95 Pain Relevance 0.08
VEGF is not only involved in the regulation of neovascularization, it also has been proven in animal studies that if VEGF were suppressed at the level of mRNA or protein, corneal neovascularization was also decreased [2,14,27].
Transcription (level) of VEGF associated with corneal neovascularization
16) Confidence 0.59 Published 2010 Journal Korean Journal of Ophthalmology : KJO Section Body Doc Link PMC2916105 Disease Relevance 0.51 Pain Relevance 0.03
In this study, the PRP containing high amount of VEGF and PMP and PBMNCs without PBPMNs was called angiogenic factor-enriched PRP.
Transcription (amount) of VEGF
17) Confidence 0.55 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.10 Pain Relevance 0
Analysis of VEGF transcripts by PCR, DNA cloning (Tischer et al. 1991) or RT-PCR (Poltorak et al. 1997) identified 5 isoforms with 121, 141, 145, 165 and 189 amino acids.
Transcription (transcripts) of VEGF
18) Confidence 0.53 Published 2007 Journal Genomic Med Section Body Doc Link PMC2276892 Disease Relevance 0.61 Pain Relevance 0.16
Endostatin also interacts with VEGF signal transduction by reducing VEGF-induced kinase (Erk1/2) phosphorylation [25].
Transcription (transduction) of VEGF
19) Confidence 0.53 Published 2008 Journal J Orthop Surg Section Body Doc Link PMC2397381 Disease Relevance 0.17 Pain Relevance 0.16
In an attempt to characterize factors affecting production and secretion of VEGF in EP, expression of VEGF mRNA and the VEGF receptors KDR and flt-1 were measured in implanted and non-implanted sites of the oviduct in women with EP41.
Transcription (expression) of VEGF in oviduct associated with ectopic pregnancy
20) Confidence 0.52 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.88 Pain Relevance 0.05

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