INT68681
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Using a co-culture system comprised of murine peritoneal macrophages and intervertebral disc tissue as a model of the acute phase of HD developed previously, an increase in macrophage VEGF protein and mRNA expression was observed upon exposure to disc tissue. | |||||||||||||||
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Hypoxia-induced transcription of VEGF mRNA is mediated by binding of hypoxia-inducible factor 1 (HIF-1) [7]. | |||||||||||||||
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We observed no significant deviation from the untreated mRNA levels for VEGF and bFGF during a 48 hour period after treatment with glucose alone or in combination with fluvastatin. | |||||||||||||||
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Our study revealed a striking restriction of VEGF and bFGF mRNA expression in the diabetic sub-group of the atherosclerosis patient group with stable angina pectoris while the non diabetic sub-group displayed levels similar to the normal group. | |||||||||||||||
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To determine the effect of fluvastatin on the mRNA expression of bFGF and VEGF in monocytes of a healthy donor we performed kinetic analysis. | |||||||||||||||
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Real time reverse transcriptase polymerase chain reaction showed that morphine treatment (100 ng/ml) of hypoxic HUVECs resulted in a significant reduction in mRNA levels of VEGF(121) and VEGF(165) isoforms. | |||||||||||||||
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Real time reverse transcriptase polymerase chain reaction showed that morphine treatment (100 ng/ml) of hypoxic HUVECs resulted in a significant reduction in mRNA levels of VEGF(121) and VEGF(165) isoforms. | |||||||||||||||
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The intra assay variability of the mRNA measurements of our in vitro short term culture system was assessed by measuring the VEGF and bFGF mRNA in triplicate cultures each. | |||||||||||||||
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Quantitation of the mRNA for VEGF, bFGF and TGF-? | |||||||||||||||
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Quantitation of the mRNA for VEGF, bFGF and TGF-? | |||||||||||||||
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Furthermore we analyzed in the above model the effect of high glucose levels found in diabetic individuals and statins found in the medication of all our patients on the mRNA levels of VEGF and bFGF during a 48 hour period. | |||||||||||||||
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Although both forms of the disease exhibited high levels of angiogenic activity, inflammatory breast cancer showed significantly higher mRNA expression of angiogenic and lymphangiogenic genes, including those encoding for VEGF-C and VEGF-D. | |||||||||||||||
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Although both forms of the disease exhibited high levels of angiogenic activity, inflammatory breast cancer showed significantly higher mRNA expression of angiogenic and lymphangiogenic genes, including those encoding for VEGF-C and VEGF-D. | |||||||||||||||
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One such example involves hypoxia-inducible factor-1, a transcription factor that regulates the expression of many angiogenesis- and glucose metabolism-related genes and in addition activates the transcription of VEGF in malignant gliomas.38,39 VEGF mRNA expression, as well as VEGF receptor expression, are well documented hypoxic induced changes in malignant gliomas.40 | |||||||||||||||
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One such example involves hypoxia-inducible factor-1, a transcription factor that regulates the expression of many angiogenesis- and glucose metabolism-related genes and in addition activates the transcription of VEGF in malignant gliomas.38,39 VEGF mRNA expression, as well as VEGF receptor expression, are well documented hypoxic induced changes in malignant gliomas.40 | |||||||||||||||
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VEGF is not only involved in the regulation of neovascularization, it also has been proven in animal studies that if VEGF were suppressed at the level of mRNA or protein, corneal neovascularization was also decreased [2,14,27]. | |||||||||||||||
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In this study, the PRP containing high amount of VEGF and PMP and PBMNCs without PBPMNs was called angiogenic factor-enriched PRP. | |||||||||||||||
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Analysis of VEGF transcripts by PCR, DNA cloning (Tischer et al. 1991) or RT-PCR (Poltorak et al. 1997) identified 5 isoforms with 121, 141, 145, 165 and 189 amino acids. | |||||||||||||||
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Endostatin also interacts with VEGF signal transduction by reducing VEGF-induced kinase (Erk1/2) phosphorylation [25]. | |||||||||||||||
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In an attempt to characterize factors affecting production and secretion of VEGF in EP, expression of VEGF mRNA and the VEGF receptors KDR and flt-1 were measured in implanted and non-implanted sites of the oviduct in women with EP41. | |||||||||||||||
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