INT68682

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2011
Negated 16
Speculated 8
Reported most in Abstract
Documents 640
Total Number 648
Disease Relevance 454.14
Pain Relevance 81.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
plasma 32
blood 12
endothelial cell 12
lung 11
HGF 11
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4913 100.00 Very High Very High Very High
cytokine 2263 100.00 Very High Very High Very High
ischemia 790 100.00 Very High Very High Very High
COX2 81 100.00 Very High Very High Very High
Glutamate receptor 26 100.00 Very High Very High Very High
Serotonin 13 100.00 Very High Very High Very High
carpal tunnel syndrome 6 100.00 Very High Very High Very High
Cannabinoid receptor 4 100.00 Very High Very High Very High
Delta opioid receptors 2 100.00 Very High Very High Very High
agonist 1811 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 13232 100.00 Very High Very High Very High
INFLAMMATION 5314 100.00 Very High Very High Very High
Hypoxia 2708 100.00 Very High Very High Very High
Apoptosis 1766 100.00 Very High Very High Very High
Infection 1672 100.00 Very High Very High Very High
Lymphedema 789 100.00 Very High Very High Very High
Cv Unclassified Under Development 604 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 492 100.00 Very High Very High Very High
Necrosis 446 100.00 Very High Very High Very High
Pre-eclampsia 322 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have described an atypical clinical presentation in a patient with isolated splenic peliosis associated with elevated VEGF concentrations.
Positive_regulation (elevated) of VEGF
1) Confidence 0.70 Published 2004 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 15618852 Disease Relevance 0.51 Pain Relevance 0.09
He was found to have massively elevated levels of vascular endothelial growth factor (VEGF).
Positive_regulation (elevated) of VEGF
2) Confidence 0.70 Published 2004 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 15618852 Disease Relevance 0.53 Pain Relevance 0.05
In response to hypoxia, VEGF121 and VEGF165 mRNA were both remarkably increased, while there was no change in VEGF mRNA stability.
Positive_regulation (increased) of VEGF121
3) Confidence 0.70 Published 2007 Journal J. Oral Pathol. Med. Section Body Doc Link 17448139 Disease Relevance 0.15 Pain Relevance 0
Circulating VEGF levels were increased (from 116+/-29 to 169+/-45 pg/ml; P=0.002), and the levels of VEGF were correlated significantly with exercise tolerance in a positive direction (r=0.88, P=0.004), in those patients treated with cilostazol that did not have diabetes mellitus.
Positive_regulation (increased) of VEGF associated with diabetes mellitus and tolerance
4) Confidence 0.69 Published 2001 Journal Clin. Sci. Section Abstract Doc Link 11524048 Disease Relevance 0.38 Pain Relevance 0.38
Vascular endothelial growth factor (VEGF), a key modulator of angiogenesis, endothelial cell proliferation and migration, chemotaxis, and capillary hyperpermeability, is upregulated in a number of physiological and pathological conditions associated with hypoperfusion and/or hypoxia [7, 23].
Positive_regulation (upregulated) of Vascular endothelial growth factor in capillary associated with hypoxia
5) Confidence 0.69 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2765643 Disease Relevance 1.91 Pain Relevance 0.27
Vascular endothelial growth factor (VEGF), a key modulator of angiogenesis, endothelial cell proliferation and migration, chemotaxis, and capillary hyperpermeability, is upregulated in a number of physiological and pathological conditions associated with hypoperfusion and/or hypoxia [7, 23].
Positive_regulation (upregulated) of VEGF in capillary associated with hypoxia
6) Confidence 0.69 Published 2007 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2765643 Disease Relevance 1.84 Pain Relevance 0.27
The increase of VEGF on admission in the patients with AMI may be due to the hypoxia of acute myocardial ischemia.
Positive_regulation (increase) of VEGF associated with coronary artery disease, hypoxia, ischemia and myocardial infarction
7) Confidence 0.69 Published 2000 Journal Cardiology Section Abstract Doc Link 10894913 Disease Relevance 0.86 Pain Relevance 0.19
Hypoxia-induced VEGF in endothelial cells and cardiomyocytes leads to autocrine and paracrine stimulation, respectively.
Positive_regulation (induced) of VEGF in endothelial cells associated with hypoxia
8) Confidence 0.69 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.55 Pain Relevance 0.42
During myocardial ischemia, VEGF is upregulated in the endothelium and myocardium, and may mediate angiogenesis.
Positive_regulation (upregulated) of VEGF in myocardium associated with coronary artery disease and ischemia
9) Confidence 0.69 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.60 Pain Relevance 0.47
Transfection of HUVECs with a human VEGF promoter-luciferase construct showed that hypoxia-induced transcriptional activation of VEGF was markedly inhibited by morphine sulfate (P<0.05).
Positive_regulation (activation) of VEGF associated with hypoxia and morphine
10) Confidence 0.69 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.74 Pain Relevance 1.06
Phosphatidyl inositol-3 kinase and protein kinase C-mediated activation of the VEGF promoter was also inhibited by morphine.
Positive_regulation (activation) of VEGF promoter associated with kinase c and morphine
11) Confidence 0.69 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.71 Pain Relevance 1.10
Tumor necrosis factor alpha (TNF-alpha) was required for this induction of VEGF.
Positive_regulation (induction) of VEGF associated with necrosis and cancer
12) Confidence 0.69 Published 2002 Journal J. Orthop. Res. Section Abstract Doc Link 12038611 Disease Relevance 0.92 Pain Relevance 0.26
CONCLUSIONS: Cyclooxygenase 2 does not regulate VEGF in pancreatic cancer, and celecoxib upregulates VEGF in pancreatic cancer.
Positive_regulation (upregulates) of VEGF
13) Confidence 0.69 Published 2010 Journal Pancreas Section Body Doc Link 20118820 Disease Relevance 0.06 Pain Relevance 0
Celecoxib increased VEGF in a concentration-dependent manner in each cell line up to 4-fold (P < 0.05).
Positive_regulation (increased) of VEGF
14) Confidence 0.69 Published 2010 Journal Pancreas Section Body Doc Link 20118820 Disease Relevance 0.07 Pain Relevance 0
BMI resulted in lower levels of VEGF and bFGF, and this fall is the hallmark of the effectiveness of BMI in the treatment of peripheral artery disease.
Positive_regulation (resulted) of VEGF in artery associated with peripheral arterial disease
15) Confidence 0.69 Published 2006 Journal Angiology Section Abstract Doc Link 16518534 Disease Relevance 0.42 Pain Relevance 0.20
Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia.
Spec (whether) Positive_regulation (increased) of vascular endothelial growth factor in pericardial fluid associated with angina, coronary artery disease and ischemia
16) Confidence 0.69 Published 1998 Journal Angiogenesis Section Abstract Doc Link 14517380 Disease Relevance 0.57 Pain Relevance 0.45
The level of VEGF in pericardial fluid was increased only in patients with severe rest angina within 2 days before emergency coronary artery bypass graft surgery (CABG), while bFGF was increased in all patients undergoing CABG for coronary artery disease.
Positive_regulation (increased) of VEGF in coronary artery associated with angina, coronary artery disease and emergencies
17) Confidence 0.69 Published 1998 Journal Angiogenesis Section Abstract Doc Link 14517380 Disease Relevance 0.83 Pain Relevance 0.52
Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia.
Spec (whether) Positive_regulation (increased) of VEGF in pericardial fluid associated with angina, coronary artery disease and ischemia
18) Confidence 0.69 Published 1998 Journal Angiogenesis Section Abstract Doc Link 14517380 Disease Relevance 0.57 Pain Relevance 0.45
VEGF is mainly upregulated by hypoxia and other factors.
Positive_regulation (upregulated) of VEGF associated with hypoxia
19) Confidence 0.69 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2635972 Disease Relevance 0.36 Pain Relevance 0
In T1 group, VEGF level reduced in serum, but increased in urine after BCG therapy.
Positive_regulation (increased) of VEGF in urine
20) Confidence 0.68 Published 2010 Journal Urology Annals Section Body Doc Link PMC2955232 Disease Relevance 0.53 Pain Relevance 0

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