INT68683

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2011
Negated 14
Speculated 25
Reported most in Abstract
Documents 143
Total Number 168
Disease Relevance 104.19
Pain Relevance 20.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
endothelial cells 15
fibroblasts 11
endometrium 10
plasma 10
epithelial cells 8
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 398 100.00 Very High Very High Very High
agonist 373 100.00 Very High Very High Very High
metalloproteinase 195 100.00 Very High Very High Very High
diclofenac 190 100.00 Very High Very High Very High
dexamethasone 159 100.00 Very High Very High Very High
Morphine 27 100.00 Very High Very High Very High
antidepressant 15 100.00 Very High Very High Very High
qutenza 13 100.00 Very High Very High Very High
Clonidine 6 100.00 Very High Very High Very High
Arthritis 101 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 3547 100.00 Very High Very High Very High
Hypoxia 597 100.00 Very High Very High Very High
Ovarian Cancer 224 100.00 Very High Very High Very High
Adhesions 137 100.00 Very High Very High Very High
Necrosis 67 100.00 Very High Very High Very High
Skin Cancer 48 100.00 Very High Very High Very High
Ectopic Pregnancy 285 99.96 Very High Very High Very High
Papilledema 5 99.92 Very High Very High Very High
Bursitis 1 99.88 Very High Very High Very High
Arthritis 115 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since relaxin regulates the expression of MMPs and VEGF in the endometrium, we tested the hypothesis that relaxin plays a role in endometriosis by comparing the expression of relaxin mRNA and its LGR7 (RXFP1) receptor mRNA in normal human endometrium to those in samples from patients with endometriosis.
Regulation (regulates) of Gene_expression (expression) of VEGF in endometrium associated with endometriosis and metalloproteinase
1) Confidence 0.62 Published 2009 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 19416175 Disease Relevance 0.64 Pain Relevance 0.41
We investigated the effect of morphine sulfate on VEGF expression in cultured endothelial cells and cardiac myocytes subjected to hypoxia.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of VEGF in endothelial cells associated with hypoxia and morphine
2) Confidence 0.61 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.70 Pain Relevance 0.57
Our results show that the inhibitory effects of morphine on hypoxia-induced VEGF expression in endothelial cells and cardiac myocytes can lead to a decrease in the autocrine and paracrine stimulation and hence limit neovascularization of the ischemic myocardium.
Regulation (effects) of Gene_expression (expression) of VEGF in myocardium associated with hypoxia and morphine
3) Confidence 0.61 Published 2001 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 11735263 Disease Relevance 0.56 Pain Relevance 1.02
The effect of clonidine on VEGF expression in human retinal pigment epithelial cells (ARPE-19).
Regulation (effect) of Gene_expression (expression) of VEGF in epithelial cells associated with clonidine
4) Confidence 0.61 Published 2009 Journal Graefes Arch. Clin. Exp. Ophthalmol. Section Title Doc Link 19011889 Disease Relevance 0 Pain Relevance 0.24
Cytokines may also modulate angiogenesis by regulating VEGF expression, for example, tumor necrosis factor (TNF)-?
Regulation (regulating) of Gene_expression (expression) of VEGF associated with necrosis, cancer and cytokine
5) Confidence 0.60 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2875768 Disease Relevance 1.35 Pain Relevance 0.05
The implantation environment in the oviduct is very different from that of the well-vascularized endometrium, and production and secretion of VEGF may be affected in EP.
Spec (may) Regulation (affected) of Gene_expression (production) of VEGF in oviduct associated with ectopic pregnancy
6) Confidence 0.60 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.65 Pain Relevance 0.04
Thus, the death of alveolar epithelial cells could be partially responsible for the decreased expression of VEGF [50].
Spec (partially) Regulation (responsible) of Gene_expression (expression) of VEGF in epithelial cells associated with death
7) Confidence 0.59 Published 2006 Journal Crit Care Section Body Doc Link PMC1751039 Disease Relevance 0.48 Pain Relevance 0
HIF, which is induced by cell hypoxia, is one of the most important regulators of VEGF gene expression [28].
Regulation (regulators) of Gene_expression (expression) of VEGF gene associated with hypoxia
8) Confidence 0.59 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2958987 Disease Relevance 1.13 Pain Relevance 0.04
Analysis of these data, collectively, unveils a signaling pathway responsible for synthesis of VEGF by pulp cells and suggests a novel therapeutic target for the management of vascular responses in teeth with pulpitis.
Regulation (responsible) of Gene_expression (synthesis) of VEGF in teeth associated with pulpitis
9) Confidence 0.57 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20110511 Disease Relevance 0.16 Pain Relevance 0.21
We have reported that reactive oxygen species (ROS), generated by phagocytic cells at the site of tissue injury, serve as major signaling molecules regulating the expression of vascular endothelial growth factor (VEGF) and subsequent wound repair.
Regulation (regulating) of Gene_expression (expression) of VEGF associated with injury
10) Confidence 0.57 Published 2004 Journal World J Surg Section Abstract Doc Link 14961185 Disease Relevance 1.18 Pain Relevance 0.08
To date, the effect of VEGF expression on tumor response to LD chemotherapy has not been investigated.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of VEGF associated with cancer
11) Confidence 0.55 Published 2008 Journal J Transl Med Section Body Doc Link PMC2235830 Disease Relevance 1.06 Pain Relevance 0
First, by determining the requirement for VEGF in the actions of a 5-HT selective reuptake inhibitor (SSRI), fluoxetine in behavioral models of depression/antidepressant response; and second, by examining the role of the 5-HT1A receptor subtype in the regulation of VEGF, and the cellular localization of antidepressant regulation of VEGF expression.
Regulation (regulation) of Gene_expression (expression) of VEGF associated with antidepressant, depression, ssri and fluoxetine
12) Confidence 0.54 Published 2009 Journal Neuropsychopharmacology Section Abstract Doc Link 19553916 Disease Relevance 0.18 Pain Relevance 0.64
VEGF expression is controlled by a number of complex regulatory mechanisms [47].
Regulation (controlled) of Gene_expression (expression) of VEGF
13) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776981 Disease Relevance 1.16 Pain Relevance 0.07
In the present study, we examined the effect of capsaicin on constitutive and induced vascular endothelial cell growth factor (VEGF) expression in malignant melanoma cells.
Spec (examined) Regulation (effect) of Gene_expression (expression) of VEGF in endothelial cell associated with qutenza and skin cancer
14) Confidence 0.45 Published 2002 Journal J. Cancer Res. Clin. Oncol. Section Abstract Doc Link 12242509 Disease Relevance 0.35 Pain Relevance 0.27
When general anaesthesia (GA) is combined with TEA during coronary artery bypass graft, we investigated whether TEA together with GA play a role on VEGF and i-NOS expression in human heart tissue in cardiac ischemia.
Spec (whether) Regulation (role) of Gene_expression (expression) of VEGF in heart associated with anesthesia, coronary artery disease and ischemia
15) Confidence 0.45 Published 2007 Journal J Cardiovasc Surg (Torino) Section Abstract Doc Link 17308528 Disease Relevance 0.10 Pain Relevance 0.50
CONCLUSIONS: The effect of clonidine on the expression of VEGF may be via suppression of the p38MAPK and MEK1/2 signal transduction pathways activated with IL-1beta.


Regulation (effect) of Gene_expression (expression) of VEGF
16) Confidence 0.45 Published 2009 Journal Graefes Arch. Clin. Exp. Ophthalmol. Section Body Doc Link 19011889 Disease Relevance 0 Pain Relevance 0
We designed an observational study to compare the effects of standard heparin (SH) with low molecular weight heparin (LMWH) on vascular endothelial growth factor (VEGF) levels in patients undergoing coronary artery bypass grafting (CABG).
Regulation (effects) of Gene_expression (levels) of VEGF in coronary artery
17) Confidence 0.45 Published 2004 Journal Int. J. Cardiol. Section Abstract Doc Link 15093980 Disease Relevance 0.19 Pain Relevance 0.19
We designed an observational study to compare the effects of standard heparin (SH) with low molecular weight heparin (LMWH) on vascular endothelial growth factor (VEGF) levels in patients undergoing coronary artery bypass grafting (CABG).
Regulation (effects) of Gene_expression (levels) of vascular endothelial growth factor in coronary artery
18) Confidence 0.45 Published 2004 Journal Int. J. Cardiol. Section Abstract Doc Link 15093980 Disease Relevance 0.19 Pain Relevance 0.19
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro.
Regulation (modulates) of Gene_expression (expression) of VEGF in fibroblast associated with osteoarthritis
19) Confidence 0.45 Published 2010 Journal J. Orthop. Res. Section Title Doc Link 19890996 Disease Relevance 0.60 Pain Relevance 0.31
Hyaluronic acid modulates gene expression of connective tissue growth factor (CTGF), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in human fibroblast-like synovial cells from advanced-stage osteoarthritis in vitro.
Regulation (modulates) of Gene_expression (expression) of vascular endothelial growth factor in fibroblast associated with osteoarthritis
20) Confidence 0.45 Published 2010 Journal J. Orthop. Res. Section Title Doc Link 19890996 Disease Relevance 0.59 Pain Relevance 0.31

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