INT68684

Context Info Confidence 0.78 First Reported 1997 Last Reported 2011 Negated 27 Speculated 62 Reported most in Abstract Documents 2371 Total Number 2433 Disease Relevance 1742.52 Pain Relevance 259.20

extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA) proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)

Anatomy Link Frequency endothelial cells 64 fibroblasts 48 plasma 46 lung 43 macrophages 37 VEGFA (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 14671 100.00 cytokine 8486 100.00 metalloproteinase 5011 100.00 imagery 4507 100.00 chemokine 2716 100.00 Nerve growth factor 597 100.00 Inflammatory mediators 507 100.00 aspirin 242 100.00 COX2 202 100.00 Snapping jaw 120 100.00

Disease Link Frequency Relevance Heat Cancer 63655 100.00 INFLAMMATION 15764 100.00 Metastasis 9472 100.00 Apoptosis 7560 100.00 Hypoxia 7231 100.00 Breast Cancer 6221 100.00 Targeted Disruption 4624 100.00 Pancreatic Cancer 4219 100.00 Coronary Artery Disease 3462 100.00 Adhesions 3083 100.00

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Event

Anatomy

Negation

Speculation

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Disease term

Since relaxin regulates the expression of MMPs and VEGF in the endometrium, we tested the hypothesis that relaxin plays a role in endometriosis by comparing the expression of relaxin mRNA and its LGR7 (RXFP1) receptor mRNA in normal human endometrium to those in samples from patients with endometriosis.

Gene_expression (expression) of VEGF in endometrium associated with endometriosis and metalloproteinase

1) Confidence 0.78 Published 2009 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 19416175 Disease Relevance 0.64 Pain Relevance 0.41

Herein, we examined the expression of VEGF in synovial fibroblasts from temporomandibular joint (TMJ) under hypoxia and investigated the regulation of hypoxia-inducible factor-1alpha (HIF-1alpha) involved in the expression of VEGF.

Spec (examined) Gene_expression (expression) of VEGF in fibroblasts associated with snapping jaw and hypoxia

2) Confidence 0.78 Published 2007 Journal J. Oral Pathol. Med. Section Abstract Doc Link 17448139 Disease Relevance 0.44 Pain Relevance 0.17

HIF-1alpha, which is clearly activated in response to hypoxia, may control the expression of VEGF in synovial fibroblasts from TMJ.

Gene_expression (expression) of VEGF in fibroblasts

3) Confidence 0.78 Published 2007 Journal J. Oral Pathol. Med. Section Body Doc Link 17448139 Disease Relevance 0.12 Pain Relevance 0

INTRODUCTION: Enhanced expression of vascular endothelial growth factor (VEGF) has been described in patients with internal derangement (ID).

Gene_expression (expression) of vascular endothelial growth factor in internal

4) Confidence 0.78 Published 2007 Journal J. Oral Pathol. Med. Section Abstract Doc Link 17448139 Disease Relevance 0.24 Pain Relevance 0.16

INTRODUCTION: Enhanced expression of vascular endothelial growth factor (VEGF) has been described in patients with internal derangement (ID).

Gene_expression (expression) of VEGF in internal

5) Confidence 0.78 Published 2007 Journal J. Oral Pathol. Med. Section Abstract Doc Link 17448139 Disease Relevance 0.24 Pain Relevance 0.17

CONCLUSIONS: Hypoxia may mainly induce the expression of VEGF121 and VEGF165 in synovial fibroblasts to promote inflamed angiogenesis of TMJ.

Gene_expression (expression) of VEGF121 in TMJ

6) Confidence 0.78 Published 2007 Journal J. Oral Pathol. Med. Section Body Doc Link 17448139 Disease Relevance 0.13 Pain Relevance 0

Herein, we examined the expression of VEGF in synovial fibroblasts from temporomandibular joint (TMJ) under hypoxia and investigated the regulation of hypoxia-inducible factor-1alpha (HIF-1alpha) involved in the expression of VEGF.

Gene_expression (expression) of VEGF in fibroblasts associated with snapping jaw and hypoxia

7) Confidence 0.78 Published 2007 Journal J. Oral Pathol. Med. Section Abstract Doc Link 17448139 Disease Relevance 0.44 Pain Relevance 0.17

VEGF expression in the stromal cells in healthy pulps ranged from 20 to 100% (with a mean of 68.82), and in irreversible pulpitis ranged from 0 to 100% (with a mean of 62.35%); this difference was statistically significant (p = 0.05).

Gene_expression (expression) of VEGF in stromal cells associated with pulpitis

8) Confidence 0.78 Published 2002 Journal J Endod Section Abstract Doc Link 11806643 Disease Relevance 0.82 Pain Relevance 0.57

Vascular endothelial growth factor (VEGF) expression in healthy and inflamed human dental pulps.

Gene_expression (expression) of Vascular endothelial growth factor in dental pulps

9) Confidence 0.78 Published 2002 Journal J Endod Section Title Doc Link 11806643 Disease Relevance 0.71 Pain Relevance 0.47

Our immunohistochemical data show that the expression of VEGF was strongly positive in the inflammatory infiltrate in irreversible pulpitis.

Gene_expression (expression) of VEGF associated with inflammation and pulpitis

10) Confidence 0.78 Published 2002 Journal J Endod Section Abstract Doc Link 11806643 Disease Relevance 0.74 Pain Relevance 0.48

Vascular endothelial growth factor (VEGF) expression in healthy and inflamed human dental pulps.

Gene_expression (expression) of VEGF in dental pulps

11) Confidence 0.78 Published 2002 Journal J Endod Section Title Doc Link 11806643 Disease Relevance 0.71 Pain Relevance 0.47

VEGF has been found to be expressed in several different types of tumors, and it may contribute to the progression of malignant tumors.

Gene_expression (expressed) of VEGF associated with malignant neoplastic disease and cancer

12) Confidence 0.78 Published 2002 Journal J Endod Section Abstract Doc Link 11806643 Disease Relevance 0.48 Pain Relevance 0.25

Expression of vascular endothelial growth factor in human dysfunctional temporomandibular joint discs.

Gene_expression (Expression) of vascular endothelial growth factor in temporomandibular joint associated with snapping jaw

13) Confidence 0.78 Published 2003 Journal Arch. Oral Biol. Section Title Doc Link 12648555 Disease Relevance 0.44 Pain Relevance 0.48

The purpose here was to investigate, in human TMJ discs, the expression of vascular endothelial growth factor (VEGF), a multifunctional cytokine that contributes to angiogenesis.

Gene_expression (expression) of vascular endothelial growth factor in TMJ associated with snapping jaw and cytokine

14) Confidence 0.78 Published 2003 Journal Arch. Oral Biol. Section Abstract Doc Link 12648555 Disease Relevance 0.41 Pain Relevance 0.46

Therefore VEGF expression by disc chondrocyte-like cells might reflect the action of the cytokine as an inducer of angiogenesis and as an autocrine signal for cells of the chondrogenic lineage.

Gene_expression (expression) of VEGF in chondrocyte associated with cytokine

15) Confidence 0.78 Published 2003 Journal Arch. Oral Biol. Section Abstract Doc Link 12648555 Disease Relevance 0.33 Pain Relevance 0.41

In disc specimens from internal derangement of the TMJ with significant tissue degeneration/regeneration, VEGF was consistently expressed.

Gene_expression (expressed) of VEGF in TMJ associated with snapping jaw

16) Confidence 0.78 Published 2003 Journal Arch. Oral Biol. Section Abstract Doc Link 12648555 Disease Relevance 0.38 Pain Relevance 0.45

The purpose here was to investigate, in human TMJ discs, the expression of vascular endothelial growth factor (VEGF), a multifunctional cytokine that contributes to angiogenesis.

Gene_expression (expression) of VEGF in TMJ associated with snapping jaw and cytokine

17) Confidence 0.78 Published 2003 Journal Arch. Oral Biol. Section Abstract Doc Link 12648555 Disease Relevance 0.41 Pain Relevance 0.46

VEGF has more recently, also been shown to be expressed in articular cartilage chondrocytes in human osteoarthritic and rheumatoarthritic joints but not healthy adult joints.

Gene_expression (expressed) of VEGF in joints associated with osteoarthritis

18) Confidence 0.78 Published 2003 Journal J Craniomaxillofac Surg Section Abstract Doc Link 12914710 Disease Relevance 0.28 Pain Relevance 0.09

Immunohistochemical staining was employed to determine the microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression in tumor tissues.

Gene_expression (expression) of vascular endothelial growth factor

19) Confidence 0.78 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 15637740 Disease Relevance 0.24 Pain Relevance 0

Immunohistochemical staining was employed to determine the microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression in tumor tissues.

Gene_expression (expression) of VEGF

20) Confidence 0.78 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 15637740 Disease Relevance 0.24 Pain Relevance 0

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