INT6869

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Context Info
Confidence 0.61
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 34
Total Number 34
Disease Relevance 5.15
Pain Relevance 14.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car3) cytoplasm (Car3)
Anatomy Link Frequency
dentate gyrus 6
pyramidal cell 3
neurons 3
neuronal 2
pyramidal neurons 2
Car3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 96 100.00 Very High Very High Very High
Pyramidal cell 79 100.00 Very High Very High Very High
Glutamate 38 100.00 Very High Very High Very High
opioid receptor 24 100.00 Very High Very High Very High
noradrenaline 6 100.00 Very High Very High Very High
ischemia 8 99.98 Very High Very High Very High
Morphine 19 99.80 Very High Very High Very High
nMDA receptor antagonist 8 99.76 Very High Very High Very High
Potency 2 99.70 Very High Very High Very High
Dynorphin 2 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 22 100.00 Very High Very High Very High
Death 12 100.00 Very High Very High Very High
Epilepsy 2 100.00 Very High Very High Very High
Cv Unclassified Under Development 8 99.98 Very High Very High Very High
Brain Injury 16 99.24 Very High Very High Very High
Airway Obstruction 1 94.48 High High
Injury 2 94.40 High High
Depression 120 90.60 High High
Hypoxia 17 84.84 Quite High
Pressure Volume 2 Under Development 1 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, after TBI in rats treated with fentanyl, CMRglu increased markedly and bilaterally in CA1 and CA3 (p<0.05 vs. fentanyl uninjured), but not ipsilateral parietal cortex.
Positive_regulation (increased) of CA3 in parietal cortex associated with brain injury
1) Confidence 0.61 Published 2003 Journal Brain Res. Section Abstract Doc Link 14642446 Disease Relevance 0.61 Pain Relevance 0.79
Kainate was 80 times more potent in activating CA3 than CA1 pyramidal neurons on the intact side, whereas this ratio had dropped to 2.6 on the lesioned side.
Positive_regulation (activating) of CA3 in pyramidal neurons associated with pyramidal cell
2) Confidence 0.61 Published 1987 Journal Exp Brain Res Section Abstract Doc Link 2881802 Disease Relevance 0 Pain Relevance 0.56
These data indicate that both lateral and medial perforant path projections to the CA3 region display LTP, and that LTP induction in medial and lateral perforant path-CA3 synapses are differentially sensitive to NMDA receptor and mu-opioid receptor antagonists.
Positive_regulation (induction) of CA3 in synapses associated with antagonist, nmda receptor and opioid receptor
3) Confidence 0.50 Published 2002 Journal J. Neurophysiol. Section Abstract Doc Link 11826036 Disease Relevance 0 Pain Relevance 0.79
These relatively minor effects do not support the hypothesis that spontaneous waves in the dentate gyrus initiate bouts of SPWs but suggest instead that such activity increases ongoing CA3 activity.


Positive_regulation (increases) of CA3 in dentate gyrus
4) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770848 Disease Relevance 0 Pain Relevance 0.12
Addition of 3 microM KA to the culture medium over 24-48 h induced a destruction of the pyramidal cells in the CA3 region, whereas the CA1 pyramidal cells and the granule cells were left undamaged.
Positive_regulation (induced) of CA3 in pyramidal cells associated with pyramidal cell
5) Confidence 0.49 Published 1987 Journal Acta Neuropathol. Section Abstract Doc Link 3673509 Disease Relevance 0 Pain Relevance 0.32
Increases in PSP frequency were interpreted to reflect glutamate activations of CA3 neurons with local synaptic connections to recorded cells. 5.
Positive_regulation (activations) of CA3 in neurons associated with glutamate
6) Confidence 0.47 Published 1988 Journal J. Neurophysiol. Section Abstract Doc Link 2893832 Disease Relevance 0 Pain Relevance 0.57
In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands.
Positive_regulation (activation) of CA3 in dorsal associated with hippocampus
7) Confidence 0.45 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1532832 Disease Relevance 0 Pain Relevance 0.27
Hyperglycolysis was exacerbated in CA1 and CA3 hippocampus after TBI in rats treated with fentanyl vs. isoflurane anesthesia.
Positive_regulation (exacerbated) of CA3 in hippocampus associated with anesthesia, isoflurane, hippocampus and brain injury
8) Confidence 0.44 Published 2003 Journal Brain Res. Section Abstract Doc Link 14642446 Disease Relevance 0.49 Pain Relevance 0.82
We propose that the conjoint activity of the discharging CA3 cells and tetanization of these same cells by mossy fibers during exploratory (theta) behavior will temporarily increase synaptic efficacy among the active CA3 neurons even after the termination of exploration.
Positive_regulation (increase) of CA3 in neurons
9) Confidence 0.44 Published 1992 Journal Epilepsy Res. Suppl. Section Abstract Doc Link 1334667 Disease Relevance 0 Pain Relevance 0.21
In dentate, but not in CA1/CA3 slices, NA significantly enhanced K+-induced Ca2+-dependent release, and this effect was mimicked by clonidine and isoprenaline, but not by phenylephrine.
Positive_regulation (enhanced) of CA1/CA3 associated with noradrenaline and clonidine
10) Confidence 0.44 Published 1986 Journal Neuropharmacology Section Abstract Doc Link 2874519 Disease Relevance 0 Pain Relevance 0.57
For histological assessment, the ratio of the surviving neurons (ipsilateral/contralateral) was calculated in the cornu ammonis fields, CA1 and CA3, and the dentate gyrus (DG).
Positive_regulation (calculated) of CA3 in dentate gyrus
11) Confidence 0.43 Published 2008 Journal Acta Anaesthesiol Scand Section Body Doc Link 18840112 Disease Relevance 0.07 Pain Relevance 0
Morphometric analysis showed dendritic rearrangement with increased staining of MAP-2 in CA3 and the lower blade of the dentate gyrus.
Positive_regulation (increased) of CA3 in dentate gyrus
12) Confidence 0.42 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986361 Disease Relevance 0 Pain Relevance 0.23
On the lesioned side, the potency of kainate in activating CA3 pyramidal neurons was reduced by 94% compared to the same neurons on the intact side.
Positive_regulation (activating) of CA3 in neurons associated with pyramidal cell and potency
13) Confidence 0.41 Published 1987 Journal Exp Brain Res Section Abstract Doc Link 2881802 Disease Relevance 0 Pain Relevance 0.53
The long-lasting excitation in CA3 is probably related to the CA3 associational projections, because direct stimulation of CA3 pyramidal cell layer also produced similar results.
Positive_regulation (stimulation) of CA3 in pyramidal cell associated with pyramidal cell
14) Confidence 0.41 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300395 Disease Relevance 0 Pain Relevance 0.28
The inhibitory effect of Al on LTP in CA3 could be enhanced by preinjection of NG-nitro-L-arginine (0.3 mol/L, 1 microliter).
Positive_regulation (enhanced) of CA3
15) Confidence 0.41 Published 1998 Journal J. Tongji Med. Univ. Section Abstract Doc Link 10806843 Disease Relevance 0 Pain Relevance 0.16
Microinjection of Al (0.5 mol/L, 1 microliter) into CA3 could block the induction of LTP in CA3.
Positive_regulation (induction) of CA3
16) Confidence 0.41 Published 1998 Journal J. Tongji Med. Univ. Section Abstract Doc Link 10806843 Disease Relevance 0 Pain Relevance 0.17
Ten minutes forebrain ischemia induced approximately 75, 20, and 10% neuronal death in the CA1, CA3, and DG, respectively.
Positive_regulation (induced) of CA3 in forebrain associated with ischemia and death
17) Confidence 0.38 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17207574 Disease Relevance 0.86 Pain Relevance 0.87
In view of the known connectivity, CA3 labeling with both vectors is most likely mediated through synapses of the CA3 Schaffer collaterals onto first order infected CA1 neurons.
Positive_regulation (mediated) of CA3 in synapses
18) Confidence 0.38 Published 2008 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2629710 Disease Relevance 0.07 Pain Relevance 0.06
In addition, this study tested the hypothesis that in vivo exposure to different oxygen (O(2)) concentrations causes a differential activation of G proteins in the CA1, CA3, and dentate gyrus (DG) regions of the hippocampus.
Positive_regulation (activation) of CA3 in dentate gyrus associated with hippocampus
19) Confidence 0.38 Published 2007 Journal Hippocampus Section Abstract Doc Link 17598161 Disease Relevance 0.65 Pain Relevance 0.41
Alternatively, there is evidence for electrotonic coupling between pyramidal cell axons and this would be expected to enhance the recurrent activity triggered by mossy fiber-driven activation of CA3 neurons.
Positive_regulation (activation) of CA3 in pyramidal cell associated with pyramidal cell
20) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770848 Disease Relevance 0 Pain Relevance 0.14

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