INT68692

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.06
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (HTT) endoplasmic reticulum (HTT) protein complex (HTT)
cytoplasm (HTT) cytosol (HTT) cell death (HTT)
Anatomy Link Frequency
plasma 1
neurons 1
skin 1
melanocytes 1
neuropil 1
HTT (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 18 97.06 Very High Very High Very High
qutenza 3 96.14 Very High Very High Very High
Enkephalin 2 92.28 High High
Inflammation 36 77.12 Quite High
Inflammatory response 6 70.28 Quite High
Inflammatory mediators 3 59.20 Quite High
Hippocampus 3 53.60 Quite High
topical agent 3 52.40 Quite High
Analgesic 3 43.44 Quite Low
corticosteroid 6 42.72 Quite Low
Disease Link Frequency Relevance Heat
Burns 248 100.00 Very High Very High Very High
Disease 86 100.00 Very High Very High Very High
Injury 862 99.40 Very High Very High Very High
Pigment Disorder 18 98.72 Very High Very High Very High
Recurrence 14 97.36 Very High Very High Very High
Targeted Disruption 19 95.32 Very High Very High Very High
Body Weight 11 89.36 High High
Death 40 83.48 Quite High
Infection 46 82.48 Quite High
INFLAMMATION 51 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A small change in soluble huntingtin levels was observed after a 6-week period of drug treatment (Fig. 6A and B).
Regulation (change) of huntingtin
1) Confidence 0.60 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.89 Pain Relevance 0.03
Huntingtin immunoreactivity was confined primarily to neurons and neuropil within the matrix compartment, whereas little or no neuronal or neuropil huntingtin immunostaining was observed within the patch compartment.
Regulation (immunoreactivity) of Huntingtin in neurons
2) Confidence 0.27 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9096140 Disease Relevance 0 Pain Relevance 0.09
Huntingtin immunoreactivity was confined primarily to neurons and neuropil within the matrix compartment, whereas little or no neuronal or neuropil huntingtin immunostaining was observed within the patch compartment.
Regulation (immunoreactivity) of Huntingtin in neuropil
3) Confidence 0.09 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9096140 Disease Relevance 0 Pain Relevance 0.09
The Minicams™ is designed to collect HD vapor on a Tenax™ TA solid sorbent (Scientific Instrument Services, Ringoes, NJ), thermally desorb the bound agent, gas chromatographically separate mixtures, and detect HD using a flame photometric detector.
Regulation (collect) of HD
4) Confidence 0.08 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0 Pain Relevance 0
This observed microbe decontamination effect was the basis for preliminary investigation of the plasma cloud's effect on smaller chemical agent molecules such as HD.
Spec (investigation) Regulation (effect) of HD in plasma
5) Confidence 0.08 Published 2008 Journal Eplasty Section Body Doc Link PMC2481389 Disease Relevance 0.07 Pain Relevance 0
The fluids used in replacement fluid therapy for non-HD burns, which would likely be appropriate for use in HD injuries if fluid replacement is required, are described by Settle,80 Brisebois,81 and Thomas et al.82
Regulation (appropriate) of HD associated with burns and injury
6) Confidence 0.05 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 1.29 Pain Relevance 0
Top candidates that have shown efficacy in a mouse ear model include indomethacin, fluphenazine dihydrochloride, olvanil, retro olvanil, octyl homovanillamide, and other analogs of capsaicin.69–71 It remains to be determined which NSAID (or combination), route of administration, length of administration, and dosing regimen is the most efficacious in preventing or ameliorating the effects of HD on skin.
Regulation (effects) of HD in skin associated with qutenza and cinod
7) Confidence 0.05 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.48 Pain Relevance 0.68
Skin color has not been shown to affect HD penetration rates.42 Transient hyperpigmentation was reported in casualties of the 1980s Iran-Iraq War, primarily due to accumulation of melanin derived from dead melanocytes at the base of an epidermis about to desquamate, and from opacification and darkening of nonviable epidermal cells.15,43,44 Following desquamation, the skin may appear hypopigmented.
Regulation (affect) of HD in melanocytes associated with pigment disorder
8) Confidence 0.03 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.94 Pain Relevance 0
Filgrastim had no detrimental effect on acute GvHD, while the potential effect of Filgrastim therapy with regard to relapse requires further investigation.



Neg (no) Regulation (effect) of GvHD associated with disease and recurrence
9) Confidence 0.01 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2710993 Disease Relevance 0.38 Pain Relevance 0

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