INT68694

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.29
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (HTT) endoplasmic reticulum (HTT) protein complex (HTT)
cytoplasm (HTT) cytosol (HTT) cell death (HTT)
Anatomy Link Frequency
neuronal 2
primary neurons 2
neurons 2
keratinocytes 2
HTT (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 4 96.20 Very High Very High Very High
Glutamate 4 95.44 Very High Very High Very High
cerebral cortex 2 91.44 High High
Kinase C 2 84.00 Quite High
depression 9 68.72 Quite High
Enkephalin 1 50.56 Quite High
Central nervous system 6 50.48 Quite High
anesthesia 4 43.56 Quite Low
Pain management 2 14.32 Low Low
imagery 37 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Huntington's Chorea 10 100.00 Very High Very High Very High
Disease 138 99.92 Very High Very High Very High
Death 33 99.80 Very High Very High Very High
Toxicity 29 99.76 Very High Very High Very High
Cognitive Disorder 22 98.44 Very High Very High Very High
Neurodegenerative Disease 20 96.40 Very High Very High Very High
Cv Unclassified Under Development 4 96.20 Very High Very High Very High
Blister 130 95.76 Very High Very High Very High
Alzheimer's Dementia 4 94.40 High High
Stress 6 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lithium chloride treatment reduced toxicity induced by overexpression of Huntington disease exon 1 fragment with 74 glutamines in neuronal and non-neuronal cell lines [11], and attenuated toxicity of the N-terminal part of mutant huntingtin with 120 glutamine repeats in Drosophila [39].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Huntington disease in neuronal associated with toxicity and huntington's chorea
1) Confidence 0.49 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 1.23 Pain Relevance 0.03
The stable inducible PC12 cells have been previously described (11), cells were treated with doxycycline to induce huntingtin expression for 24 h at 1 µg/ml with the addition of 1 µm rilmenidine for a further 24 h and bafilomycin A1 as for primary neurons.


Positive_regulation (induce) of Gene_expression (expression) of huntingtin in primary neurons
2) Confidence 0.49 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0 Pain Relevance 0
HD is caused by a trinucleotide expansion in the IT15 gene, coding for the mutant protein huntingtin, and has an autosomal dominant hereditary pattern.
Positive_regulation (caused) of Gene_expression (expansion) of huntingtin associated with disease
3) Confidence 0.49 Published 2010 Journal Curr Treat Options Neurol Section Body Doc Link PMC2918785 Disease Relevance 1.07 Pain Relevance 0.08
These observations suggest that the selective vulnerability of spiny striatal neurons and the matrix compartment observed in Huntington's disease is associated with higher levels of huntingtin expression, whereas the relative resistance of large and medium-sized aspiny neurons and the patch compartments to degeneration is associated with low levels of huntingtin expression.
Positive_regulation (levels) of Gene_expression (expression) of huntingtin in neurons associated with disease
4) Confidence 0.46 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9096140 Disease Relevance 0.10 Pain Relevance 0.05
Carmichael et al. reported that lithium treatment partially rescued cell death in cells overexpressing Huntington disease exon 1 fragment with 74 glutamines, possibly by inhibiting GSK3 and subsequently altering gene transcription [11].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Huntington disease associated with huntington's chorea and death
5) Confidence 0.45 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1880853 Disease Relevance 1.09 Pain Relevance 0.14
Evidence that may contradict the PADPRP hypothesis includes the facts that (1) NAD+ depletion does not occur in rat keratinocytes until the concentration of HD is sufficient to inhibit DNA repair19; (2) DNA repair in human keratinocytes may be accomplished within 90 minutes of exposure,20 whereas significant NAD+ depletion is not observed until 1 to 3 hours postexposure; and (3) elevation or maintenance of NAD+ in human keratinocytes does not confer protection.21
Neg (not) Positive_regulation (occur) of Gene_expression (concentration) of HD in keratinocytes
6) Confidence 0.06 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.08 Pain Relevance 0
Previous research has enumerated a number of stable vehicles that are suitable for cutaneous exposure with liquid HD.108
Positive_regulation (suitable) of Gene_expression (exposure) of HD
7) Confidence 0.05 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.72 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox