INT6870

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2007
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 15
Disease Relevance 4.00
Pain Relevance 10.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
AV3V 1
spinal 1
neurons 1
caudate putamen 1
brain 1
Oprk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 39 100.00 Very High Very High Very High
Opioid 22 100.00 Very High Very High Very High
narcan 12 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
Morphine 10 99.98 Very High Very High Very High
Endogenous opioid 5 99.98 Very High Very High Very High
Enkephalin 12 99.44 Very High Very High Very High
antagonist 9 99.28 Very High Very High Very High
agonist 21 99.10 Very High Very High Very High
Pain 5 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 4 100.00 Very High Very High Very High
Convulsion 4 98.20 Very High Very High Very High
Bordatella Infection 4 98.18 Very High Very High Very High
Hyperalgesia 8 97.96 Very High Very High Very High
Alcohol Addiction 4 97.36 Very High Very High Very High
Urological Neuroanatomy 6 96.80 Very High Very High Very High
Hemorrhage 6 95.76 Very High Very High Very High
Neuropathic Pain 7 91.60 High High
Nervous System Injury 1 90.56 High High
INFLAMMATION 1 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On day 8, kappa-opioid receptor density was increased in the hypothalamus of rats treated with U-69593; there were no changes in the frontal cortex or caudate putamen.
Positive_regulation (increased) of kappa-opioid receptor in caudate putamen associated with kappa opioid receptor and urological neuroanatomy
1) Confidence 0.70 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 15456944 Disease Relevance 0.32 Pain Relevance 0.76
With regard to the inverted U-shaped relation between the dose of the drug and the number of self-infusions, it seems that activation of the kappa-opioid receptor with U50,488H produced an almost parallel shift to the left, indicating an increased sensitivity of the animals for the reinforcing effects of cocaine and morphine.
Spec (seems) Positive_regulation (activation) of kappa-opioid receptor associated with kappa opioid receptor, morphine and cocaine
2) Confidence 0.70 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9085036 Disease Relevance 0.08 Pain Relevance 1.26
Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain.
Positive_regulation (increases) of kappa opioid receptor in brain associated with kappa opioid receptor, enkephalin and morphine
3) Confidence 0.64 Published 1999 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 10095091 Disease Relevance 0 Pain Relevance 0.83
The inhibitory response was sensitive to pertussis toxin and highly selective for kappa-agonists; neither mu- nor delta-opioids were able to activate the kappa-opioid receptor.
Positive_regulation (activate) of kappa-opioid receptor associated with bordatella infection, kappa opioid receptor, agonist and opioid
4) Confidence 0.60 Published 1995 Journal FEBS Lett. Section Abstract Doc Link 7875310 Disease Relevance 0.19 Pain Relevance 0.41
The results indicate that kappa-opioid receptor activation has similar potential for spinal analgesia as does activation of mu-opioid receptors.
Positive_regulation (activation) of kappa-opioid receptor in spinal associated with mu opioid receptor, kappa opioid receptor and analgesia
5) Confidence 0.47 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874523 Disease Relevance 0.07 Pain Relevance 0.54
In transfected 293 cells, activation of the kappa-opioid receptor by U50,488 and the dynorphins resulted in the inhibition of cAMP accumulation.
Positive_regulation (activation) of kappa-opioid receptor associated with kappa opioid receptor
6) Confidence 0.44 Published 1995 Journal FEBS Lett. Section Abstract Doc Link 7875310 Disease Relevance 0.16 Pain Relevance 0.37
These data indicate that activation of the kappa opioid receptor exerts an inhibitory effect on absence-like seizure activity in WAG/Rij rats.
Positive_regulation (activation) of kappa opioid receptor associated with convulsion and kappa opioid receptor
7) Confidence 0.42 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7777181 Disease Relevance 0.48 Pain Relevance 0.50
The stimulation of central kappa opioid receptors decreases male sexual behavior and locomotor activity.
Positive_regulation (stimulation) of kappa opioid associated with eae, narcan and kappa opioid receptor
8) Confidence 0.35 Published 1992 Journal Brain Res. Section Title Doc Link 1334765 Disease Relevance 0.07 Pain Relevance 0.69
These results suggest that the stimulation of central kappa opioid receptors inhibits sexual behavior in the male rat; perhaps endogenous kappa opioid agonists induce sexual refractory periods.
Positive_regulation (stimulation) of kappa opioid associated with mu agonist and kappa opioid receptor
9) Confidence 0.35 Published 1992 Journal Brain Res. Section Abstract Doc Link 1334765 Disease Relevance 0.08 Pain Relevance 0.68
Kappa opioid receptor activation depresses excitatory synaptic input to rat locus coeruleus neurons in vitro.
Positive_regulation (activation) of Kappa opioid receptor in neurons associated with locus ceruleus and kappa opioid receptor
10) Confidence 0.32 Published 1987 Journal Neuroscience Section Title Doc Link 3031541 Disease Relevance 0.08 Pain Relevance 0.59
Non-inflamed paws were not influenced by kappa-2 receptor activation.
Positive_regulation (activation) of kappa-2 receptor
11) Confidence 0.25 Published 1999 Journal Pain Section Abstract Doc Link 10068171 Disease Relevance 1.24 Pain Relevance 1.09
The results of this study suggest that activation of the kappa-opiate receptor system in the AV3V region of the hypothalamus can attenuate the compensatory cardiovascular responses to hemorrhage.
Positive_regulation (activation) of kappa-opiate receptor in AV3V associated with cva and opiate
12) Confidence 0.20 Published 1993 Journal Circ. Shock Section Abstract Doc Link 8098273 Disease Relevance 0.63 Pain Relevance 0.68
An analysis of the relative expression profiles for mu, delta and kappa receptor mRNA within each culture revealed that all cultures manifested relatively high levels of delta and kappa receptor mRNA, but relatively low levels of mu receptor mRNA.
Positive_regulation (levels) of kappa receptor mRNA
13) Confidence 0.14 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8750824 Disease Relevance 0 Pain Relevance 0.17
In an earlier study, we reported that variation in the genes encoding the kappa-opioid receptor (OPRK1) and its peptide ligand (PDYN) were associated with the risk for alcoholism.
Positive_regulation (variation) of OPRK1 associated with alcohol addiction and kappa opioid receptor
14) Confidence 0.12 Published 2007 Journal Am. J. Med. Genet. B Neuropsychiatr. Genet. Section Abstract Doc Link 17503481 Disease Relevance 0.32 Pain Relevance 0.65
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
Positive_regulation (increase) of opioid kappa and delta associated with nociception, antagonist, endogenous opioid and opioid
15) Confidence 0.09 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8627559 Disease Relevance 0.29 Pain Relevance 1.69

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