INT68701

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.02
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C4bp) cytoplasm (C4bp)
Anatomy Link Frequency
plasma 1
cleavage 1
C4bp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 11 99.12 Very High Very High Very High
anesthesia 4 87.36 High High
cva 12 79.80 Quite High
Dysuria 2 77.12 Quite High
Inflammation 39 40.64 Quite Low
depression 2 25.56 Quite Low
ischemia 12 5.00 Very Low Very Low Very Low
fibrosis 10 5.00 Very Low Very Low Very Low
Inflammatory response 10 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 35 99.84 Very High Very High Very High
Thrombophilia 3 97.96 Very High Very High Very High
Scoliosis 3 97.72 Very High Very High Very High
Apoptosis 23 89.92 High High
Amyloidosis 1 88.92 High High
Disease 46 88.44 High High
Bacterial Infection 4 86.24 High High
Alzheimer's Dementia 8 85.76 High High
Ulcers 2 81.12 Quite High
Targeted Disruption 21 80.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have recently shown that in some acute-phase patients C4BP is incorrectly controlled (with elevation of the C4BP beta-containing isoforms), leading to a potential hypercoagulable state by decreasing the plasma levels of free (active) protein S.
Positive_regulation (elevation) of C4BP in plasma associated with thrombophilia
1) Confidence 0.67 Published 1997 Journal Haemostasis Section Abstract Doc Link 9097083 Disease Relevance 0.32 Pain Relevance 0.13
Our data suggest a similar evolution of C4BP isoforms in all these patients, with an almost exclusive increase of C4BP isoforms lacking C4BP beta polypeptides and steady levels of free protein S.
Positive_regulation (increase) of C4BP
2) Confidence 0.67 Published 1997 Journal Haemostasis Section Abstract Doc Link 9097083 Disease Relevance 0.30 Pain Relevance 0.09
In addition, C4bp protein levels have been shown to be upregulated in SLE [10].
Positive_regulation (upregulated) of C4bp associated with systemic lupus erythematosus
3) Confidence 0.67 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.82 Pain Relevance 0.15
Our data suggest a similar evolution of C4BP isoforms in all these patients, with an almost exclusive increase of C4BP isoforms lacking C4BP beta polypeptides and steady levels of free protein S.
Positive_regulation (evolution) of C4BP
4) Confidence 0.49 Published 1997 Journal Haemostasis Section Abstract Doc Link 9097083 Disease Relevance 0.31 Pain Relevance 0.09
C4bp may be required for optimal cell recruitment, perhaps due to binding of a chemotactic product of C4b cleavage.
Positive_regulation (required) of C4bp in cleavage
5) Confidence 0.48 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.45 Pain Relevance 0
These include binding to the complement factor C1q and preventing the inhibitory function of the complement regulatory component C4 binding protein (C4BP), both of which can lead to activation of the classical pathway of complement [8–11], and improving Fc?
Positive_regulation (lead) of C4BP
6) Confidence 0.25 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.83 Pain Relevance 0
For the classical pathway, proteins with membrane co-factor activity include C4bp, CR1, and membrane co-factor protein (MCP), while those for the alternative pathway are CR1, FH, and MCP.
Positive_regulation (include) of C4bp
7) Confidence 0.22 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727911 Disease Relevance 0 Pain Relevance 0

General Comments

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