INT68702

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 10
Disease Relevance 7.44
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C4bp) cytoplasm (C4bp)
Anatomy Link Frequency
cleavage 1
C4bp (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 38 95.56 Very High Very High Very High
Dysuria 5 81.20 Quite High
Inflammation 110 75.24 Quite High
anesthesia 5 61.12 Quite High
cva 5 53.56 Quite High
depression 5 48.24 Quite Low
Arthritis 5 22.36 Low Low
Inflammatory response 32 5.00 Very Low Very Low Very Low
fibrosis 25 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease Progression 5 99.52 Very High Very High Very High
Disease 86 99.32 Very High Very High Very High
Systemic Lupus Erythematosus 80 99.28 Very High Very High Very High
Renal Disease 45 97.24 Very High Very High Very High
Lymphadenopathy 5 94.84 High High
Scoliosis 1 93.68 High High
Autoimmune Disease 20 93.40 High High
Targeted Disruption 50 92.80 High High
Amyloidosis 4 92.68 High High
Bacterial Infection 13 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest a similar evolution of C4BP isoforms in all these patients, with an almost exclusive increase of C4BP isoforms lacking C4BP beta polypeptides and steady levels of free protein S.
Negative_regulation (lacking) of C4BP
1) Confidence 0.57 Published 1997 Journal Haemostasis Section Abstract Doc Link 9097083 Disease Relevance 0.30 Pain Relevance 0.09
We report here that C4bp deficiency does not modify disease severity in MRL/lpr mice.


Negative_regulation (deficiency) of C4bp associated with disease
2) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 1.11 Pain Relevance 0.07
There are several potential mechanisms by which C4bp deficiency may modify disease progression in SLE.
Negative_regulation (deficiency) of C4bp associated with systemic lupus erythematosus and disease progression
3) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.68 Pain Relevance 0.03
There have been no reported cases of C4bp deficiency in patients with SLE.
Negative_regulation (deficiency) of C4bp associated with systemic lupus erythematosus
4) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.77 Pain Relevance 0.11
Only one patient with C4bp deficiency has been described [12].
Negative_regulation (deficiency) of C4bp
5) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.73 Pain Relevance 0.13
Deficiency of C4bp would be expected to result in increased cleavage of C3 and in increased complement activity in response to classical pathway or lectin pathway activation by immune complex formation, bacterial infections, apoptosis, and other triggering mechanisms.
Negative_regulation (Deficiency) of C4bp in cleavage associated with apoptosis and bacterial infection
6) Confidence 0.36 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.44 Pain Relevance 0.07
These include binding to the complement factor C1q and preventing the inhibitory function of the complement regulatory component C4 binding protein (C4BP), both of which can lead to activation of the classical pathway of complement [8–11], and improving Fc?
Negative_regulation (preventing) of C4BP
7) Confidence 0.21 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.86 Pain Relevance 0
These include binding to the complement factor C1q and preventing the inhibitory function of the complement regulatory component C4 binding protein (C4BP), both of which can lead to activation of the classical pathway of complement [8–11], and improving Fc?
Negative_regulation (function) of C4 binding protein
8) Confidence 0.21 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.85 Pain Relevance 0
These include binding to the complement factor C1q and preventing the inhibitory function of the complement regulatory component C4 binding protein (C4BP), both of which can lead to activation of the classical pathway of complement [8–11], and improving Fc?
Negative_regulation (preventing) of C4 binding protein
9) Confidence 0.21 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.85 Pain Relevance 0
These include binding to the complement factor C1q and preventing the inhibitory function of the complement regulatory component C4 binding protein (C4BP), both of which can lead to activation of the classical pathway of complement [8–11], and improving Fc?
Negative_regulation (function) of C4BP
10) Confidence 0.21 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1971117 Disease Relevance 0.85 Pain Relevance 0

General Comments

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