INT68705

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.60
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C4bp) cytoplasm (C4bp)
Anatomy Link Frequency
plasma 1
C4bp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 92.76 High High
anesthesia 2 88.84 High High
cva 2 81.28 Quite High
Dysuria 2 31.84 Quite Low
cytokine 4 17.12 Low Low
fibrosis 10 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombophilia 2 96.84 Very High Very High Very High
Disease 28 95.72 Very High Very High Very High
Apoptosis 18 94.24 High High
INFLAMMATION 12 92.76 High High
Sprains And Strains 14 84.68 Quite High
Injury 34 84.04 Quite High
Alzheimer's Dementia 2 83.08 Quite High
Scoliosis 2 82.16 Quite High
Thromboembolism 2 81.64 Quite High
Acute-phase Reaction 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we have studied whether patients subjected to orthopedic surgery have an appropriate modulation of the C4BP isoforms during their postoperative acute-phase responses.
Spec (whether) Regulation (modulation) of C4BP
1) Confidence 0.60 Published 1997 Journal Haemostasis Section Abstract Doc Link 9097083 Disease Relevance 0.32 Pain Relevance 0.11
We have recently shown that in some acute-phase patients C4BP is incorrectly controlled (with elevation of the C4BP beta-containing isoforms), leading to a potential hypercoagulable state by decreasing the plasma levels of free (active) protein S.
Regulation (controlled) of C4BP in plasma associated with thrombophilia
2) Confidence 0.52 Published 1997 Journal Haemostasis Section Abstract Doc Link 9097083 Disease Relevance 0.31 Pain Relevance 0.13
C4bp, and thus negative regulation of the classical pathway of complement activation, therefore appears to play a minimal role in modulating disease severity in the MRL mouse.
Regulation (regulation) of C4bp associated with disease
3) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.67 Pain Relevance 0.05
All isoforms regulate complement in an equivalent manner, and no binding partner has been shown to modulate C4bp complement regulatory activity.
Regulation (modulate) of C4bp
4) Confidence 0.26 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.30 Pain Relevance 0

General Comments

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