INT68725

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Context Info
Confidence 0.19
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.62
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp11a1)
Anatomy Link Frequency
liver 1
extracellular matrix 1
Cyp11a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 3 98.38 Very High Very High Very High
anesthesia 13 97.84 Very High Very High Very High
Inflammation 4 86.36 High High
agonist 3 68.68 Quite High
antagonist 3 67.76 Quite High
cva 6 63.52 Quite High
colic 7 56.56 Quite High
Paracetamol 2 51.92 Quite High
cINOD 1 33.68 Quite Low
headache 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Uremia 2 99.66 Very High Very High Very High
Vomiting 67 98.86 Very High Very High Very High
Renal Insufficiency 6 93.04 High High
Disease 16 87.04 High High
INFLAMMATION 5 86.36 High High
Post-operative Nausea 74 84.56 Quite High
Emergencies 73 79.68 Quite High
Advanced Or Metastatic Breast Cancer 8 78.16 Quite High
Hypertension 2 75.00 Quite High
Toxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary culture of rat hepatocytes in 96-well plates: effects of extracellular matrix configuration on cytochrome P450 enzyme activity and inducibility, and its application in in vitro cytotoxicity screening.
Regulation (effects) of cytochrome P450 enzyme in extracellular matrix
1) Confidence 0.19 Published 2007 Journal Toxicol In Vitro Section Title Doc Link 17141466 Disease Relevance 0.07 Pain Relevance 0.05
The pathophysiological mechanism responsible for alterations in drug disposition, especially metabolism and renal excretion, is the accumulation of uraemic toxins that may modulate cytochrome P450 enzyme activity and decrease glomerular filtration as well as tubular secretion.
Regulation (modulate) of cytochrome P450 enzyme associated with uremia
2) Confidence 0.18 Published 1997 Journal Drug Saf Section Abstract Doc Link 9098657 Disease Relevance 0.51 Pain Relevance 0
As aliskiren does not affect cytochrome P450 enzyme activities, is minimally metabolised, and is not extensively protein bound, the potential for drug interactions is predicted to be low.
Neg (not) Regulation (affect) of cytochrome P450 enzyme
3) Confidence 0.04 Published 2006 Journal Int. J. Clin. Pract. Section Abstract Doc Link 17073832 Disease Relevance 0.07 Pain Relevance 0
It is at least theoretically plausible that acute phase reactants and cytokines could blockade vomiting receptors or, more likely, induce those elements of the cytochrome P450 enzyme system in the liver which are responsible for degradation of the emetogenic agents used during anesthesia [6,7].
Regulation (responsible) of cytochrome P450 enzyme in liver associated with anesthesia, vomiting and cytokine
4) Confidence 0.02 Published 2010 Journal BMC Surg Section Body Doc Link PMC2838816 Disease Relevance 1.56 Pain Relevance 0.26
Apart from food intake, pharmacogenetic factors (e.g. the wide variability in CYP 3A, the cytochrome P450 enzyme responsible for artemether and lumefantrine metabolism [3,13]) and differences in nutritional status in African patients may be important and are avenues for further research.
Regulation (responsible) of cytochrome P450 enzyme
5) Confidence 0.00 Published 2006 Journal Malar J Section Body Doc Link PMC1543643 Disease Relevance 0.05 Pain Relevance 0
They target the aromatase enzyme (a P-450 cytochrome enzyme), which converts testosterone and adrenal androgens to estradiol and other estrogens (Smith and Dowsett 2003).
Regulation (target) of P-450 cytochrome enzyme
6) Confidence 0.00 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.35 Pain Relevance 0.13

General Comments

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