INT68735

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.05
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.22
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Arg2)
Arg2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal inflammation 14 90.64 High High
Inflammation 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 2 90.64 High High
Disease 9 54.16 Quite High
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Ankylosing Spondylitis 12 5.00 Very Low Very Low Very Low
Rheumatic Diseases 12 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B*2704 and B*2706 shared with B*2705, among other features, their selectivity for Arg2 and their allowance for some aliphatic and aromatic C-terminal residues in their bound peptides.
Arg2 Binding (selectivity) of
1) Confidence 0.05 Published 1997 Journal Tissue Antigens Section Abstract Doc Link 9098927 Disease Relevance 0.22 Pain Relevance 0.17
For the B*2705 allele, more extensive hydrogen bonding is observed between the peptide and the protein: In Figure 7A, ARG5 of the peptide binds to ASN97 and ASP116; in Figure 7B, ARG1 of the peptide binds to GLU163; in Figure 7C, ARG2 of the peptide binds to THR24; in Figure 7D, ARG2 of the peptide is bonded to TYR7 and LYS3 of the peptide is bonded to TYR99.
ARG2 Binding (binds) of
2) Confidence 0.04 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900293 Disease Relevance 0 Pain Relevance 0
In B*2709, ARG1 and ARG2 of the peptide bind strongly to the B pocket and the rest of the peptide remains relatively flexible contributing to the entropic advantage.
ARG2 Binding (bind) of
3) Confidence 0.03 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900293 Disease Relevance 0 Pain Relevance 0
For the B*2705 allele, more extensive hydrogen bonding is observed between the peptide and the protein: In Figure 7A, ARG5 of the peptide binds to ASN97 and ASP116; in Figure 7B, ARG1 of the peptide binds to GLU163; in Figure 7C, ARG2 of the peptide binds to THR24; in Figure 7D, ARG2 of the peptide is bonded to TYR7 and LYS3 of the peptide is bonded to TYR99.
ARG2 Binding (binds) of
4) Confidence 0.03 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900293 Disease Relevance 0 Pain Relevance 0
For the B*2705 allele, more extensive hydrogen bonding is observed between the peptide and the protein: In Figure 7A, ARG5 of the peptide binds to ASN97 and ASP116; in Figure 7B, ARG1 of the peptide binds to GLU163; in Figure 7C, ARG2 of the peptide binds to THR24; in Figure 7D, ARG2 of the peptide is bonded to TYR7 and LYS3 of the peptide is bonded to TYR99.
ARG2 Binding (binds) of
5) Confidence 0.03 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2900293 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox