INT68740

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Context Info
Confidence 0.55
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 13.68
Pain Relevance 5.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl2) extracellular region (Cxcl2)
Anatomy Link Frequency
Monocyte 2
macrophages 1
plasma 1
bladder 1
bowel 1
Cxcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 435 100.00 Very High Very High Very High
Inflammation 366 100.00 Very High Very High Very High
chemokine 104 100.00 Very High Very High Very High
dexamethasone 4 99.76 Very High Very High Very High
Inflammatory response 101 99.68 Very High Very High Very High
Morphine 9 98.74 Very High Very High Very High
Nicotine 80 94.80 High High
cINOD 1 94.48 High High
anesthesia 22 93.04 High High
Inflammatory mediators 12 91.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 482 100.00 Very High Very High Very High
Corneal Disease 30 98.84 Very High Very High Very High
Pneumonia 3 98.70 Very High Very High Very High
Targeted Disruption 43 98.60 Very High Very High Very High
Influenza Virus Infection 5 98.38 Very High Very High Very High
Adhesions 12 97.60 Very High Very High Very High
Infection 200 97.48 Very High Very High Very High
Apoptosis 60 97.44 Very High Very High Very High
Injury 264 97.16 Very High Very High Very High
Disease 67 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, timely downregulation of corneal MIP-2 was shown to correlate with a decrease in PMNs in resistant mice and was followed by corneal healing and reestablishment of ocular integrity [16,22].
Negative_regulation (downregulation) of MIP-2
1) Confidence 0.55 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.07 Pain Relevance 0.30
The local effect of radiotherapy on an exposed segment of small bowel includes early increases in MIP-2 levels, a decrease in CD 45 positive cells over time and increased dose dependent apoptosis.
Negative_regulation (decrease) of MIP-2 in bowel associated with apoptosis
2) Confidence 0.41 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.46 Pain Relevance 0.26
The results showed that MIP-2 protein expression levels were reduced significantly (p=0.000) one, three, five, and seven days post-infection in the MIP-2 treated group compared to the infected group and that the KC protein expression levels decreased slightly (p>0.05).
Negative_regulation (reduced) of MIP-2 protein associated with infection
3) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.49 Pain Relevance 0.28
Following treatment with an MIP-2 polyclonal antibody, the corneal clinical scores and inflammatory responses decreased, the MIP-2 protein levels were downregulated significantly (p<0.01), and the KC protein levels decreased slightly (p>0.05).
Negative_regulation (downregulated) of MIP-2 protein associated with inflammatory response
4) Confidence 0.41 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2707360 Disease Relevance 0.81 Pain Relevance 0.35
polyclonal antibody, the severity of corneal disease was significantly reduced, and this was accompanied by a reduction in corneal PMN cells, bacterial load, and MIP-2 mRNA and protein expression.
Negative_regulation (reduction) of MIP-2 associated with corneal disease
5) Confidence 0.41 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 1.34 Pain Relevance 0.23
The peak expression levels of MIP-2, KC, and IL-1?
Negative_regulation (levels) of MIP-2
6) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.90 Pain Relevance 0.36
AIM OF THE STUDY: In this study, we investigated the therapeutic effect of IFA on the progression of lethal influenza virus pneumonia in mice by comparison with that of dexamethasone (DX), a potent inhibitor for various inflammatory cytokines including MIP-2.
Negative_regulation (inhibitor) of MIP-2 associated with inflammation, influenza virus infection, pneumonia, dexamethasone and cytokine
7) Confidence 0.36 Published 2001 Journal Mediators Inflamm Section Abstract Doc Link PMC1781695 Disease Relevance 1.37 Pain Relevance 0.59
At the peak of neutrophil infiltration (i.e. 24 h of reperfusion), MIP-2 levels were significantly attenuated, suggesting that neutrophils had infiltrated the liver parenchyma in response to the necrotic hepatocytes.
Negative_regulation (attenuated) of MIP-2 in neutrophil
8) Confidence 0.24 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.87 Pain Relevance 0.25
Similar to the other cytokines noted above, plasma chemokine MIP-2 level significantly increased in vehicle-treated mice after 3 and 6 h of reperfusion, then decreased by 24 h (Figure 5).
Negative_regulation (decreased) of MIP-2 in plasma associated with chemokine and cytokine
9) Confidence 0.21 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 0.37 Pain Relevance 0.60
Specific chemoattractants such as KC (Keratinocyte Chemoattractant), JE/MCP-1 (Monocyte Chemoattractant Protein 1), MCP-5 (Monocyte Chemoattractant Protein 5) and MIP-2 (Macrophage Inflammatory Protein 2) are also diminished in mice treated with hAFSC.
Negative_regulation (diminished) of Macrophage Inflammatory Protein 2 in Monocyte associated with inflammation
10) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 1.01 Pain Relevance 0.46
Specific chemoattractants such as KC (Keratinocyte Chemoattractant), JE/MCP-1 (Monocyte Chemoattractant Protein 1), MCP-5 (Monocyte Chemoattractant Protein 5) and MIP-2 (Macrophage Inflammatory Protein 2) are also diminished in mice treated with hAFSC.
Negative_regulation (diminished) of MIP-2 in Monocyte associated with inflammation
11) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827539 Disease Relevance 1.01 Pain Relevance 0.46
In morphine-treated animals, before neutrophil recruitment, a significant decrease in TNF-alpha, IL-1, IL-6, MIP-2, and KC was observed both in bronchoalveolar lavage fluids and in lung tissue.
Negative_regulation (decrease) of MIP-2 in lung associated with morphine
12) Confidence 0.13 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15611267 Disease Relevance 0.45 Pain Relevance 0.70
Further, estrogen at physiological levels reduces IL-6, and MIP-2 production in many cell types, including macrophages [27,31,32].
Negative_regulation (reduces) of MIP-2 in macrophages
13) Confidence 0.12 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1764413 Disease Relevance 0.44 Pain Relevance 0.12
Deltorphin-Dvariant, but not DADLE or DPDPE, dose-dependently reduced both TNFalpha and MIP-2 production.
Negative_regulation (reduced) of MIP-2
14) Confidence 0.10 Published 2005 Journal J. Surg. Res. Section Body Doc Link 15921696 Disease Relevance 0 Pain Relevance 0
This study examined the ability of a phospholipase A2 inhibitor, anti-inflammatory peptide 2 (antinflammin), to reduce the formation of intraperitoneal adhesions in two rabbit models of adhesion formation.
Spec (examined) Negative_regulation (inhibitor) of anti-inflammatory peptide 2 associated with inflammation and adhesions
15) Confidence 0.08 Published 1997 Journal J Invest Surg Section Abstract Doc Link 9100172 Disease Relevance 1.16 Pain Relevance 0.18
We only found significantly reduced KC and MIP-2 levels in bladder homogenates from S100A9 KO mice, respectively 24 hours after infection with 9×108 CFU and 48 hours after infection with 4.5×108 CFU.
Negative_regulation (reduced) of MIP-2 in bladder associated with targeted disruption, chemokine and infection
16) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954806 Disease Relevance 1.93 Pain Relevance 0.40

General Comments

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