INT68744

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Context Info
Confidence 0.80
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 8.65
Pain Relevance 8.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl1) extracellular region (Cxcl1)
Anatomy Link Frequency
Kupffer cells 4
hepatocytes 3
neurons 2
macrophage 1
neurosecretory cells 1
Cxcl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 126 100.00 Very High Very High Very High
cytokine 80 100.00 Very High Very High Very High
chemokine 58 100.00 Very High Very High Very High
ischemia 36 100.00 Very High Very High Very High
Calcitonin gene-related peptide 31 100.00 Very High Very High Very High
Hyperalgesia 11 100.00 Very High Very High Very High
Perioperative pain 2 99.96 Very High Very High Very High
nociceptor 10 99.82 Very High Very High Very High
Paracetamol 20 99.40 Very High Very High Very High
cva 49 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 159 100.00 Very High Very High Very High
Hyperalgesia 16 100.00 Very High Very High Very High
Cv General 4 Under Development 11 100.00 Very High Very High Very High
Post Operative Pain 2 99.96 Very High Very High Very High
Nociception 31 99.44 Very High Very High Very High
Pulmonary Embolism 45 98.88 Very High Very High Very High
Bordatella Infection 3 98.40 Very High Very High Very High
Ganglion Cysts 16 94.28 High High
Hypersensitivity 10 92.00 High High
Injury 25 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that CINC-1, released at sites of inflammation, mediates inflammatory hyperalgesia in rats via release of sympathomimetic amines.
Localization (released) of CINC-1 associated with hyperalgesia and inflammation
1) Confidence 0.80 Published 2002 Journal Eur. Cytokine Netw. Section Abstract Doc Link 12517731 Disease Relevance 0.89 Pain Relevance 0.43
Influence of acetaminophen treatment and hydrogen peroxide treatment on the release of a CINC-related protein and TNF-alpha from rat hepatocyte cultures.
Localization (release) of CINC-related in hepatocyte associated with paracetamol
2) Confidence 0.79 Published 1997 Journal Toxicology Section Title Doc Link 9230444 Disease Relevance 0.11 Pain Relevance 0.28
Likewise, exposure of hepatocytes to 10-50 mM acetaminophen resulted in a dose-dependent release of the CINC-related protein after 24 h of culture.
Localization (release) of CINC-related in hepatocytes associated with paracetamol
3) Confidence 0.79 Published 1997 Journal Toxicology Section Abstract Doc Link 9230444 Disease Relevance 0.15 Pain Relevance 0.34
and chemokines, such as CXCL1/KC, are released earlier [6].
Localization (released) of CXCL1 associated with chemokine
4) Confidence 0.78 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.88 Pain Relevance 0.57
Thus, in our model of postoperative pain, secretion of inflammatory cytokines IL-1beta, IL-6, TNF-alpha, and CINC-1 was not essential for the initiation of postoperative hyperalgesia.
Localization (secretion) of CINC-1 associated with hyperalgesia, inflammation, perioperative pain and cytokine
5) Confidence 0.78 Published 2007 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 17823623 Disease Relevance 0.95 Pain Relevance 0.88
These data suggest that CINC-1, released at sites of inflammation, mediates inflammatory hyperalgesia in rats via release of sympathomimetic amines.
Localization (release) of CINC-1 associated with hyperalgesia and inflammation
6) Confidence 0.75 Published 2002 Journal Eur. Cytokine Netw. Section Abstract Doc Link 12517731 Disease Relevance 0.89 Pain Relevance 0.43
CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons.
Localization (release) of CXCL1 in neurons associated with nociception, nociceptor and calcitonin gene-related peptide
7) Confidence 0.75 Published 2005 Journal J. Neurosci. Res. Section Title Doc Link 16047385 Disease Relevance 0.72 Pain Relevance 1.00
In contrast, monomeric CINC (molecular weight approximately 6.5 kDa) but not the 28 kDa CINC-related protein was released by lipopolysaccharide (LPS)-stimulated Kupffer cells.
Localization (released) of CINC-related in Kupffer cells
8) Confidence 0.69 Published 1997 Journal Toxicology Section Abstract Doc Link 9230444 Disease Relevance 0.23 Pain Relevance 0.37
In addition, APAP inhibited the release of monomeric CINC from LPS-activated Kupffer cells and of TNF-alpha from hepatocytes even at concentrations that were not sufficient to affect cell viability.
Localization (release) of CINC in Kupffer cells
9) Confidence 0.69 Published 1997 Journal Toxicology Section Abstract Doc Link 9230444 Disease Relevance 0.24 Pain Relevance 0.34
It is suggested from the present results that, in response to a noxious stimulation, CINC is released from hypothalamic neurosecretory cells via both the anterior and posterior pituitary system.
Localization (released) of CINC in neurosecretory cells
10) Confidence 0.68 Published 1997 Journal Neurosci. Res. Section Abstract Doc Link 9100261 Disease Relevance 0.09 Pain Relevance 0.11
PLC-, PKC-, and calcium-induced calcium release from ryanodine-sensitive calcium stores signaling pathways are involved in CCL2- and CXCL1-induced CGRP release from primary nociceptive neurons, in which chemokines produce painful effects via direct actions on chemokine receptors expressed by nociceptive neurons.
Localization (release) of CXCL1 in neurons associated with nociception, pain, chemokine, kinase c and calcitonin gene-related peptide
11) Confidence 0.66 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.76 Pain Relevance 1.03
Immunohistochemical staining of GRO/KC receptor CXCR2 in sectioned DRG tissue
Localization (tissue) of GRO/KC
12) Confidence 0.64 Published 2008 Journal Mol Pain Section Body Doc Link PMC2562993 Disease Relevance 0 Pain Relevance 0.06
In contrast, monomeric CINC (molecular weight approximately 6.5 kDa) but not the 28 kDa CINC-related protein was released by lipopolysaccharide (LPS)-stimulated Kupffer cells.
Localization (released) of CINC in Kupffer cells
13) Confidence 0.61 Published 1997 Journal Toxicology Section Abstract Doc Link 9230444 Disease Relevance 0.23 Pain Relevance 0.37
Measured levels of the chemokines MCP-1, CINC-1, CINC-2, and CINC-3 are shown in Table 1 and were not significantly different in the PE versus sham animals at either time point.


Localization (levels) of CINC-1 associated with chemokine and cva
14) Confidence 0.51 Published 2010 Journal Thromb J Section Body Doc Link PMC2843658 Disease Relevance 0.73 Pain Relevance 0.41
The generation of cytokine-induced neutrophil chemoattractant (CINC) by hepatocytes and Kupffer cells of LPS-treated rats, as well as TNF-alpha secretion by Kupffer cells and alveolar macrophages of acutely ethanol intoxicated rats are also gender dependent.
Localization (secretion) of CINC in Kupffer cells associated with cytokine
15) Confidence 0.45 Published 1999 Journal Lupus Section Abstract Doc Link 10455517 Disease Relevance 0.23 Pain Relevance 0.22
The CGRP release by CCL2 and CXCL1 was significantly inhibited by EGTA, omega-conotoxin GVIA (an N-type calcium channel blocker), thapsigargin, and ryanodine.
Localization (release) of CXCL1 associated with calcium channel, conotoxin and calcitonin gene-related peptide
16) Confidence 0.29 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.72 Pain Relevance 0.96
The generation of cytokine-induced neutrophil chemoattractant (CINC) by hepatocytes and Kupffer cells of LPS-treated rats, as well as TNF-alpha secretion by Kupffer cells and alveolar macrophages of acutely ethanol intoxicated rats are also gender dependent.
Localization (secretion) of CINC in hepatocytes associated with cytokine
17) Confidence 0.15 Published 1999 Journal Lupus Section Abstract Doc Link 10455517 Disease Relevance 0.23 Pain Relevance 0.22
stimulate the production and release of specific chemokines after cerebral ischemia, such as CINC (cytokine induced neutrophil chemoattractant), MCP-1 (monocyte chemoattractant 1), fractalkine, MRF-1 (microglial response factor-1) and MIP-1 (macrophage inflammatory protein 1).
Localization (release) of CINC in macrophage associated with chemokine, inflammation, cv general 4 under development, ischemia and cytokine
18) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.60 Pain Relevance 0.57

General Comments

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