INT68758

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Context Info
Confidence 0.46
First Reported 1995
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 125
Total Number 129
Disease Relevance 82.72
Pain Relevance 25.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ros1) cell proliferation (Ros1) plasma membrane (Ros1)
Anatomy Link Frequency
vasculature 5
liver 3
spinal cord 3
neuronal 3
heart 2
Ros1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 512 100.00 Very High Very High Very High
Kinase C 99 100.00 Very High Very High Very High
Calcium channel 19 100.00 Very High Very High Very High
Dorsal horn neuron 7 100.00 Very High Very High Very High
Glutamate 49 99.92 Very High Very High Very High
Spinal cord 123 99.84 Very High Very High Very High
Inflammation 532 99.72 Very High Very High Very High
cva 63 99.72 Very High Very High Very High
Dopamine 124 99.70 Very High Very High Very High
spinal dorsal horn 28 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperglycemia 185 99.98 Very High Very High Very High
Stress 1324 99.90 Very High Very High Very High
Hyperoxia 68 99.90 Very High Very High Very High
Diabetes Mellitus 1215 99.84 Very High Very High Very High
Nociception 6 99.84 Very High Very High Very High
Apoptosis 1107 99.80 Very High Very High Very High
INFLAMMATION 645 99.72 Very High Very High Very High
Hemorrhage 48 99.72 Very High Very High Very High
Cancer 392 99.68 Very High Very High Very High
Injury 460 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since ROS may promote the release of ATP from cells, we hypothesized that activation of P2X purinoceptors by ATP subsequent to an increase in ROS induces LAH in an inflamed larynx that has been insulted by acid-pepsin or H(2)O(2) (a major type of ROS).
Positive_regulation (increase) of ROS in larynx associated with asthma
1) Confidence 0.46 Published 2009 Journal J. Appl. Physiol. Section Abstract Doc Link 19246655 Disease Relevance 0.63 Pain Relevance 0.09
The negative effects of noise on cell structure and function were supposed to be, at least in part, mediated by the increase of reactive oxygen species (ROS) (Lenzi et al. 2003).
Positive_regulation (increase) of ROS
2) Confidence 0.41 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1253657 Disease Relevance 0.13 Pain Relevance 0.05
The results suggest that elevated ROS in the spinal cord and the colon are involved in visceral pain.
Positive_regulation (elevated) of ROS in spinal cord associated with visceral pain and spinal cord
3) Confidence 0.41 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18514415 Disease Relevance 0.16 Pain Relevance 0.52
Furthermore, these events are dependent on increased ROS generation and, possibly, a subsequent decrease in tissue NO levels during systemic hypoxia.
Spec (possibly) Positive_regulation (increased) of ROS associated with hypoxia
4) Confidence 0.41 Published 2000 Journal J. Appl. Physiol. Section Abstract Doc Link 11007596 Disease Relevance 0.71 Pain Relevance 0.09
In conclusion, the results suggested that ischemia-induced arrhythmia mechanisms might involve the formation of superoxide and other ROS, which were probably generated from the release of EOP (or EOP/EOP receptor interactions).
Positive_regulation (generated) of ROS associated with ischemia and arrhythmia under development
5) Confidence 0.40 Published 1995 Journal Free Radic. Biol. Med. Section Abstract Doc Link 9101252 Disease Relevance 0.61 Pain Relevance 0.49
Increased levels of ROS within the prostate stimulate cell proliferation, induce somatic DNA mutations and promote genetic instability facilitating the development and progression of PC [2].
Positive_regulation (Increased) of ROS associated with reprotox - general 1
6) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011012 Disease Relevance 1.58 Pain Relevance 0.04
More specifically, increased levels of ROS can cause oxidative DNA damage.
Positive_regulation (increased) of ROS
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011012 Disease Relevance 1.00 Pain Relevance 0.07
Since oxidation of DA and xanthines generates reactive oxygen species (ROS) and AA and UA are the main cellular antioxidants, these findings suggest that: (a) single morphine administration increases DA and xanthine oxidative metabolism with a consequent increase in ROS production, which may account for changes in concentrations of extracellular AA and tissue DHAA; (b) allopurinol decreases morphine-induced DA and xanthine oxidation; (c) UA and AA may act in concert to regulate levels of ROS in the brain.
Positive_regulation (generates) of ROS in brain associated with dopamine and morphine
8) Confidence 0.38 Published 1997 Journal Pharmacol. Res. Section Abstract Doc Link 9356212 Disease Relevance 0 Pain Relevance 0.92
However, the findings that caffeine prevents cataract formation induced by a strongly potent cataractogenic agent such as galactose in vivo and against UV induced ROS damaged noted earlier suggest the suitability of its use pharmacologically, particularly as an eye drop for cataract prevention or delay.
Positive_regulation (induced) of ROS in eye associated with cataract
9) Confidence 0.35 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3002968 Disease Relevance 0.79 Pain Relevance 0.04
Increased ROS further caused apoptosis via mitochondrial driven pathway.
Positive_regulation (Increased) of ROS associated with apoptosis
10) Confidence 0.35 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19460394 Disease Relevance 0.69 Pain Relevance 0.17
Result indicated that arsenic moiety in GaAs was mainly responsible for causing oxidative stress via increased reactive oxygen species (ROS) and nitric oxide (NO) generation, both in vitro and in vivo.
Positive_regulation (increased) of ROS associated with stress
11) Confidence 0.35 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19460394 Disease Relevance 0.67 Pain Relevance 0.17
These data suggest that increased mitochondrial ROS in dorsal horn neurons may contribute to central sensitization in neuropathic rats.
Positive_regulation (increased) of ROS in dorsal horn associated with central sensitization, neuropathic pain and dorsal horn neuron
12) Confidence 0.34 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16183198 Disease Relevance 0.59 Pain Relevance 0.39
ROS levels increased 2-fold at 30 min after tetracaine treatment compared with the control and then decreased.
Positive_regulation (increased) of ROS
13) Confidence 0.31 Published 2009 Journal Br J Anaesth Section Body Doc Link 19720611 Disease Relevance 0 Pain Relevance 0
Our findings suggest that laryngeal insult with acid-pepsin or H(2)O(2) induces inflammation and produces excess ROS in the rat's larynx.
Positive_regulation (excess) of ROS in larynx associated with inflammation
14) Confidence 0.31 Published 2009 Journal J. Appl. Physiol. Section Abstract Doc Link 19246655 Disease Relevance 0.64 Pain Relevance 0.31
Therefore, in this study, we have performed two animal experiments to examine whether the increased ROS is involved in central sensitization through NMDA receptor phosphorylation in CPIP model.
Spec (whether) Positive_regulation (increased) of ROS associated with pain, central sensitization and nmda receptor
15) Confidence 0.27 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2884210 Disease Relevance 1.06 Pain Relevance 1.32
From this, it is suggested that the development of the allodynia mechanism, expressed in the CPIP model, may result in the increased ROS in spinal cord or peripheral tissue enhances NMDA receptor phosphorylation to induce central sensitization.
Positive_regulation (increased) of ROS in spinal cord associated with pain, central sensitization, allodynia, nmda receptor and spinal cord
16) Confidence 0.27 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2884210 Disease Relevance 1.21 Pain Relevance 1.42
ROS are inevitable byproducts generated by cell metabolism and homeostasis, and have been shown to exert regulatory roles in controlling cell proliferation, survival, and differentiation [8] However, the accumulation of ROS, a typical phenomenon of PC [5], triggers a host of pro-carcinogenic processes.
Positive_regulation (accumulation) of ROS associated with reprotox - general 1
17) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3011012 Disease Relevance 0.92 Pain Relevance 0.06
The anti-apoptotic effects of ALA were closely associated with the inhibition of ROS generation, increased activity of pERK 1/2 and decreased activity of pJNK 1/2.
Positive_regulation (generation) of ROS associated with apoptosis
18) Confidence 0.25 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 0.96 Pain Relevance 0.05
This anti-apoptotic effect of ALA was observed to be closely associated with the inhibition of ROS generation, the increased activity of pERK 1/2 and the decreased activity of pJNK 1/2.
Positive_regulation (generation) of ROS associated with apoptosis
19) Confidence 0.25 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 1.36 Pain Relevance 0.15
ROS activity is known to be elevated during hyperoxia [28,29].
Positive_regulation (elevated) of ROS associated with hyperoxia
20) Confidence 0.25 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1797183 Disease Relevance 1.20 Pain Relevance 0

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