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Context Info
Confidence 0.28
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.59
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dentate gyrus 1
dorsal root ganglion 1
cortex 1
dental pulp 1
IER3 (Homo sapiens)
Pain Link Frequency Relevance Heat
long-term potentiation 34 98.98 Very High Very High Very High
Enkephalin 5 98.84 Very High Very High Very High
cINOD 2 97.92 Very High Very High Very High
Limbic system 1 96.32 Very High Very High Very High
dorsal root ganglion 2 93.82 High High
aspirin 2 91.80 High High
Antinociceptive 4 91.60 High High
antidepressant 22 87.08 High High
Inflammation 7 85.28 High High
depression 3 84.48 Quite High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 1 99.98 Very High Very High Very High
Aids-related Complex 14 99.96 Very High Very High Very High
Cold Sores 2 99.68 Very High Very High Very High
Schizophrenia 1 98.76 Very High Very High Very High
INFLAMMATION 9 96.48 Very High Very High Very High
Herpes Simplex Virus 2 96.42 Very High Very High Very High
Ganglion Cysts 2 93.82 High High
Injury 1 92.40 High High
Apoptosis 137 90.64 High High
Gastrointestinal Neoplasms 1 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two Cox genes have been cloned, of which Cox-2 is an inducible immediate-early gene.
Positive_regulation (inducible) of immediate-early gene
1) Confidence 0.28 Published 1997 Journal Cancer Res. Section Abstract Doc Link 9102213 Disease Relevance 0.70 Pain Relevance 0.28
B, IER3 was induced in WTSTS cells compared to USTS cells.
Positive_regulation (induced) of IER3
2) Confidence 0.26 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.38 Pain Relevance 0
It was hypothesized that PCP induction of the immediate-early gene, c-fos, should be seen in areas associated with emotional behavior, such as the cortex and limbic system.
Positive_regulation (induction) of immediate-early gene in cortex associated with limbic system
3) Confidence 0.18 Published 1997 Journal Brain Res. Section Abstract Doc Link 9203533 Disease Relevance 0.10 Pain Relevance 0.22
We have previously reported that transient stimulation of the dental pulp with noxious heat evokes the induction of the immediate early gene product Fos in the transitional region between subnucleus interpolaris and caudalis (Vi/Vc) and subnucleus caudalis (Vc).
Positive_regulation (induction) of immediate early gene product in dental pulp
4) Confidence 0.15 Published 2002 Journal Pain Section Abstract Doc Link 12237184 Disease Relevance 0.33 Pain Relevance 0.12
We transfected neurons of the dorsal root ganglion in vivo by footpad inoculation with 30 microl (3 x 10(7) p.f.u.) of a replication-incompetent (ICP4-deleted) herpes simplex virus (HSV) vector with a cassette containing a portion of the human proenkephalin gene coding for 5 met- and 1 leu-enkephalin molecules under the control of the human cytomegalovirus immediate-early promoter (HCMV IEp) inserted in the HSV thymidine kinase (tk) locus.
Positive_regulation (inserted) of immediate-early promoter in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, cold sores, herpes simplex virus, cytomegalovirus infection and enkephalin
5) Confidence 0.04 Published 2001 Journal Gene Ther. Section Abstract Doc Link 11319622 Disease Relevance 0.72 Pain Relevance 0.77
Local infusion of BDNF into the dentate gyrus induces a long-term potentiation (BDNF-LTP) of synaptic transmission that requires upregulation of the immediate early gene Arc.
Positive_regulation (upregulation) of immediate early gene in dentate gyrus associated with aids-related complex and long-term potentiation
6) Confidence 0.01 Published 2007 Journal Neural Plasticity Section Abstract Doc Link PMC2248427 Disease Relevance 0.36 Pain Relevance 0.41

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