INT68774

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Context Info
Confidence 0.21
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.99
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ikbkb) kinase activity (Ikbkb) cytoplasm (Ikbkb)
Anatomy Link Frequency
spinal cord 1
Ikbkb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 1 99.12 Very High Very High Very High
cytokine 11 98.06 Very High Very High Very High
withdrawal 1 97.32 Very High Very High Very High
Enkephalin 3 96.36 Very High Very High Very High
agonist 6 95.44 Very High Very High Very High
intrathecal 1 91.24 High High
Antihyperalgesic 4 86.72 High High
Inflammation 23 82.20 Quite High
Hyperalgesia 1 80.84 Quite High
opioid receptor 3 79.60 Quite High
Disease Link Frequency Relevance Heat
Stress 1 98.82 Very High Very High Very High
Hyperalgesia 2 97.44 Very High Very High Very High
INFLAMMATION 22 82.20 Quite High
Nociception 1 70.40 Quite High
Nervous System Injury 1 69.12 Quite High
Autoimmune Disease 12 64.32 Quite High
Targeted Disruption 3 56.96 Quite High
Opportunistic Infections 1 48.56 Quite Low
Toxicity 1 45.60 Quite Low
Infection 1 32.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon activation of the cell following the binding of cytokines and growth factors or by UV or stress, a signal transduction cascade unravels that leads to the activation of the serine-threonine kinases, IKK1 and IKK2.
Positive_regulation (activation) of IKK2 associated with stress and cytokine
1) Confidence 0.21 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.52 Pain Relevance 0.24
These findings indicate that activation of presumed kappa-2 receptors in the rat spinal cord results in suppression of the hyperalgesic state without influencing normal sensitivity to noxious stimuli.
Positive_regulation (activation) of kappa-2 in spinal cord associated with hyperalgesia and spinal cord
2) Confidence 0.07 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9103490 Disease Relevance 0.46 Pain Relevance 1.15

General Comments

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