INT68781

Context Info Confidence 0.58 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 15 Total Number 15 Disease Relevance 10.01 Pain Relevance 2.42

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)

Anatomy Link Frequency joint 1 motor nerve 1 cleavage 1 TFAM (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 92 99.54 Multiple sclerosis 68 99.12 Nerve growth factor 5 97.36 Glutamate receptor 5 97.12 Arthritis 13 97.08 Neuronal excitability 25 96.56 Glutamate 40 96.40 Neurotransmitter 2 96.20 aspirin 49 94.32 halothane 15 91.64

Disease Link Frequency Relevance Heat INFLAMMATION 99 99.54 Multiple Sclerosis 69 99.12 Diabetes Mellitus 94 98.80 Cancer 101 98.44 Disease 90 97.64 Arthritis 17 97.08 Colon Cancer 5 96.84 Stress 16 96.80 Syndrome 10 96.80 Endometroid Carcinoma 72 96.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The inhibition of mtTFA activity may interrupt the ability of cancer cells to compensate for oxidative stress.

Negative_regulation (inhibition) of mtTFA associated with stress and cancer

1) Confidence 0.58 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.02 Pain Relevance 0

The down-regulation of mtTFA was also reported to be significantly associated with the disease progress of colorectal cancer [9].

Negative_regulation (regulation) of mtTFA associated with colon cancer and disease

2) Confidence 0.43 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 0.72 Pain Relevance 0

Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.

Negative_regulation (levels) of TFAM

3) Confidence 0.39 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0

Microsomal TFA and bromide formation were inhibited 45 to 66% and 21 to 26%, respectively, by the P450 2A6 inhibitors 8-methoxypsoralen and coumarin, 84 to 90% by the P450 2E1 inhibitor 4-methylpyrazole and 55% by diethyldithiocarbamate, an inhibitor of both P450 2A6 and 2E1.

Negative_regulation (inhibited) of TFA

4) Confidence 0.29 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9103523 Disease Relevance 0.25 Pain Relevance 0.35

These and other studies [17] clearly show that inhibition of specific MAPKs or transcription factor may be an effective approach for the inhibition of joint destruction in arthritis.

Negative_regulation (inhibition) of transcription factor in joint associated with arthritis

5) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.57 Pain Relevance 0.28

Another transcription factor that we found in our transcription analysis, CDC5L, was downregulated.

Negative_regulation (downregulated) of transcription factor

6) Confidence 0.06 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2227948 Disease Relevance 1.18 Pain Relevance 0.31

Further, transfection of promoter genes of MMPs and their transcription factors clearly exhibited that inhibition of MMP-2 and MMP-9 was due to down-regulation of transcription factor, NF-kappaB.

Negative_regulation (regulation) of transcription factor

7) Confidence 0.05 Published 2007 Journal Bioorg. Med. Chem. Section Abstract Doc Link 17498959 Disease Relevance 0.48 Pain Relevance 0.20

It also suppresses Luman, another cellular transcription factor that binds HCF.

Negative_regulation (suppresses) of transcription factor

8) Confidence 0.04 Published 2008 Journal J. Neurovirol. Section Abstract Doc Link 19016376 Disease Relevance 0.35 Pain Relevance 0.21

A possible mechanism for this anti-inflammatory action is through the inhibition of its transcription factor, NF-?

Negative_regulation (inhibition) of transcription factor associated with inflammation

9) Confidence 0.02 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 1.18 Pain Relevance 0.51

reduction in erythroid lineage-transcription factor, GATA-1, levels [180].

Negative_regulation (reduction) of transcription factor

10) Confidence 0.01 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.33 Pain Relevance 0.07

it is striking that huge interpersonal variation exists in all three groups, and it is likely that this transcription factor is indeed downregulated in some relatives and type 2 diabetic patients, but not in all.

Negative_regulation (downregulated) of transcription factor associated with diabetes mellitus

11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.31 Pain Relevance 0

It is clear that a failure of immunoregulatory mechanisms can indeed lead to simultaneous increases in diverse types of pathology because genetic defects of Foxp3, a transcription factor that plays a crucial role in the development and function of Tregs, leads to a syndrome known as X-linked autoimmunity-allergic dysregulation syndrome (XLAAD), which includes aspects of allergy, autoimmunity, and enteropathy [20].

Negative_regulation (defects) of transcription factor associated with autoimmune disease, syndrome, enteropathy and hypersensitivity

12) Confidence 0.01 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.50 Pain Relevance 0.07

Moreover, inhibition of host cell transcription occurs via inactivation of transcription factor TFIIIC [40] and cleavage of the TATA box binding protein (TBP) by 3Cpro [199].

Negative_regulation (inactivation) of transcription factor TFIIIC in cleavage

13) Confidence 0.01 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.08 Pain Relevance 0

Behaviorally-driven reductions in the mRNA encoding this transcription factor could ultimately affect downstream molecules that function in vocal exploration, especially during sensorimotor learning.

Negative_regulation (reductions) of transcription factor

14) Confidence 0.00 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2796720 Disease Relevance 0.17 Pain Relevance 0

In this mechanism, activation by the excitatory neurotransmitter glutamate of metabotropic glutamate receptors (mGluRs) located at motor nerve terminals decreases excitability by activating PI3 kinase (PI3K), consequently causing the phosphorylation and inhibition of the transcription factor Foxo.

Negative_regulation (inhibition) of transcription factor in motor nerve associated with glutamate, neurotransmitter and glutamate receptor

15) Confidence 0.00 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2581892 Disease Relevance 0.88 Pain Relevance 0.41

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