INT68792

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.81
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
embryos 1
neuroblast 1
neurons 1
proximal 1
Mphi 1
p53-ps (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 23 99.72 Very High Very High Very High
Hippocampus 10 99.28 Very High Very High Very High
Kinase C 4 93.96 High High
Inflammation 8 82.80 Quite High
Action potential 3 76.72 Quite High
tetrodotoxin 1 76.20 Quite High
Thalamus 2 75.20 Quite High
cocaine 3 75.00 Quite High
ischemia 14 74.60 Quite High
amygdala 2 74.40 Quite High
Disease Link Frequency Relevance Heat
Gestational Diabetes 18 99.50 Very High Very High Very High
Convulsion 6 99.46 Very High Very High Very High
Apoptosis 479 99.44 Very High Very High Very High
Aids-related Complex 22 98.72 Very High Very High Very High
Suicidal Behaviour 162 98.60 Very High Very High Very High
Hepatocellular Cancer 5 97.38 Very High Very High Very High
Cancer 33 97.16 Very High Very High Very High
Neointima 8 95.76 Very High Very High Very High
Neurodegenerative Disease 49 94.52 High High
Retinoblastoma 1 93.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mohd Yusof et al. determine the antiproliferative and apoptosis effects of hot water extract of Chlorella vulgaris on the hepatoma cell line, HepG2 and conclude that it may have anticancer effects possibly by inducing apoptosis signaling cascades via increased expression of P53, Bax and caspase?
Gene_expression (expression) of P53 associated with hepatocellular cancer and apoptosis
1) Confidence 0.75 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020329 Disease Relevance 0.82 Pain Relevance 0.07
Maternal diabetes did not alter embryonic p53 (as noted previously [43]) and PARP expression in the present study, despite a putative PARP activity increase due to the presence of DNA damage in the MD embryos (29).
Gene_expression (expression) of p53 in embryos associated with gestational diabetes
2) Confidence 0.52 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.46 Pain Relevance 0.05
No significant differences were found with regard to gene expression of AR, GAPDH, p53, and PARP (Fig. 3).
Gene_expression (expression) of p53
3) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2584142 Disease Relevance 0.37 Pain Relevance 0
Between P40 and P53, sIPSCs were rare; tonic, bicuculline-sensitive currents and noise were greater in amplitude, with mean values of -17 pA and 22 pA2 at -70 mV, they were present in all cells but they were not inhibited by TTX.
Gene_expression (present) of P53
4) Confidence 0.38 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9104595 Disease Relevance 0 Pain Relevance 0.28
Our present study investigated the effects of treatments with different addictive drugs on gene expression of murine double minute clone 2 (MDM2), a key negative regulator of p53 and an important mediator in cell apoptosis.
Gene_expression (expression) of p53 associated with apoptosis
5) Confidence 0.13 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14625023 Disease Relevance 0.27 Pain Relevance 0.48
Estrogen's anti-apoptotic role may be to prevent the initiation of apoptosis in the first place, by suppressing expression of p53-activated proteins like Fas (as reported above) and Bax [37] or alternatively, antagonizing p53 more directly.
Gene_expression (expression) of p53 associated with apoptosis
6) Confidence 0.11 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.85 Pain Relevance 0
While our data indicates that estrogen suppresses the expression of p53-induced proteins like Bax [37] and Fas, other data indicates that p53 can suppress estrogen receptor activation [85], by preventing ER-alpha binding to EREs.
Gene_expression (expression) of p53
7) Confidence 0.11 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.12 Pain Relevance 0
In the adult rat hippocampus, seizure leads to the co-localized expression of p53 and Fas in CA1 neurons [36].
Gene_expression (expression) of p53 in neurons associated with convulsion and hippocampus
8) Confidence 0.11 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.91 Pain Relevance 0.07
Morphine promoted the synthesis of Bax and p53 proteins by Mphi.
Gene_expression (synthesis) of p53 in Mphi associated with morphine
9) Confidence 0.11 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9469450 Disease Relevance 0.72 Pain Relevance 1.43
For detection of acetylated p53 (1?
Gene_expression (detection) of p53
10) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.22 Pain Relevance 0
One hypothesis that remains to be tested, is that estrogen receptors and p53 may be mutually repressive.
Gene_expression (repressive) of p53
11) Confidence 0.10 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.08 Pain Relevance 0
Competing intrinsic (p53, cell cycle, FLIP expression), proximal (extra-cellular matrix) and extrinsic factors (gonadal hormones) collectively regulate Fas suicide-sensitivity either during neurogenesis, or possibly during neuronal migration, and may ultimately determine which neuroblasts successfully contribute neurons to the differentiating cortical plate.



Gene_expression (expression) of p53 in proximal associated with suicidal behaviour and neurodegenerative disease
12) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Abstract Doc Link PMC395829 Disease Relevance 0.68 Pain Relevance 0
CHB50 cortical neuroblasts were therefore cultured under the +tsTA and -tsTA conditions as published previously [37] to examine the p53-related expression of Fas, and under the -tsTA conditions to examine the estrogen regulation of Fas during neuroblast differentiation (in the context of p53 activation).


Gene_expression (expression) of p53 in neuroblast
13) Confidence 0.09 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC395829 Disease Relevance 0.27 Pain Relevance 0
overexpression of wild-type p53 both induced apoptosis and inhibited SMC migration resulting in a reduction in lesion formation [51].
Gene_expression (overexpression) of p53 associated with apoptosis
14) Confidence 0.04 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC323957 Disease Relevance 1.04 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox