INT68794

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 1.38
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LIF) extracellular region (LIF)
Anatomy Link Frequency
Dia 1
kidney 1
LIF (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 4 96.40 Very High Very High Very High
antagonist 3 91.32 High High
tetrodotoxin 2 91.16 High High
nMDA receptor 2 90.88 High High
anesthesia 3 84.96 Quite High
endometriosis 6 80.24 Quite High
Spinal cord 1 78.20 Quite High
agonist 5 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 27 99.60 Very High Very High Very High
Sleep Disorders 5 89.92 High High
Reprotox - General 3 21 85.80 High High
Leukemia 10 85.16 High High
Male Infertility 6 84.72 Quite High
Polycystic Ovary Syndrome 6 81.88 Quite High
Endometriosis (extended) 6 80.24 Quite High
Adhesions 8 38.16 Quite Low
Stress Incontinence 4 33.40 Quite Low
Increased Venous Pressure Under Development 3 25.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Due to ethical limitations, biopsies of endometrial tissue from failed pregnancies are not easily available, thus limiting a direct evaluation of CLDN4/LIF immunolabeling in these cases.
Negative_regulation (evaluation) of LIF
1) Confidence 0.41 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
We then compared the CLDN4 and LIF immunolabeling data within each patient.
Negative_regulation (compared) of LIF
2) Confidence 0.41 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0 Pain Relevance 0
A review of LIF immunolabeling in stages of luteal phase
Negative_regulation (review) of LIF
3) Confidence 0.41 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2675529 Disease Relevance 0.49 Pain Relevance 0.04
In REM sleep, the negative pressure response by TP and SP were small, whereas both VT (38%) and Dia(slope) (24%) were greatly decreased (P < 0.02) compared with REM control.
Negative_regulation (decreased) of Dia in Dia
4) Confidence 0.37 Published 2001 Journal J. Appl. Physiol. Section Abstract Doc Link 11641373 Disease Relevance 0 Pain Relevance 0
Inactivation of IL6ST, a component of the functional receptors for LIF and OSM, leads to developmental defects in the kidney [53,54].
Negative_regulation (Inactivation) of LIF in kidney
5) Confidence 0.36 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.09 Pain Relevance 0
In contrast, only actomyosin ATPase activity of type IIb fibers was reduced (approximately 20%) in ST Dia(m).
Negative_regulation (reduced) of Dia
6) Confidence 0.02 Published 1997 Journal J. Appl. Physiol. Section Abstract Doc Link 9104851 Disease Relevance 0 Pain Relevance 0.20
In conclusion, our results suggest that in anoxia, dEMG activity is detectable during diaEMG suppression in early anoxia, irrespective of the developmental age, the anesthetic (pentobarbital or ketamine-xylazine), vagotomy, or MK-801 injections.
Negative_regulation (suppression) of diaEMG associated with ketamine and hypoxia
7) Confidence 0.00 Published 2004 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 15644935 Disease Relevance 0.41 Pain Relevance 0.23
In anoxia, we first observed dEMG activity, mostly sporadic (days 5 and 10) or mostly tonic (days 16 and 24), when diaEMG activity was temporarily suppressed (we termed it Phase 1).
Negative_regulation (suppressed) of diaEMG associated with hypoxia
8) Confidence 0.00 Published 2004 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 15644935 Disease Relevance 0.39 Pain Relevance 0.23

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