INT68797

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Context Info
Confidence 0.55
First Reported 1997
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
EM-2 2
Em (Mus musculus)
Pain Link Frequency Relevance Heat
tail-flick 10 100.00 Very High Very High Very High
Codeine 24 99.64 Very High Very High Very High
Antinociceptive 6 97.44 Very High Very High Very High
antinociception 2 81.36 Quite High
Morphine 2 77.92 Quite High
mu opioid receptor 2 75.20 Quite High
tolerance 4 75.00 Quite High
Spinal cord 2 72.88 Quite High
Enkephalin 3 50.00 Quite Low
addiction 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: These results show that serum levels of EM-1 are decreased by physical dependence on ethanol and that this effect is not directly mediated through MEnk.


Negative_regulation (decreased) of EM-1
1) Confidence 0.55 Published 2004 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 15166656 Disease Relevance 0 Pain Relevance 0
EM-1 (32.7 nM) pretreatment for 1.5 h produced 5.3- and only 2.4-folds shift to the right of the dose-response curves for EM-1- and EM-2-induced tail-flick inhibition, respectively, while EM-2 (70 nM) pretreatment for 1 h caused 4.3- and 4.5-folds shift to the right for EM-2- and EM-1-induced tail-flick inhibition, respectively.
Negative_regulation (inhibition) of EM-2 in EM-2 associated with tail-flick
2) Confidence 0.33 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12932813 Disease Relevance 0 Pain Relevance 0.58
EM-1 (32.7 nM) pretreatment for 1.5 h produced 5.3- and only 2.4-folds shift to the right of the dose-response curves for EM-1- and EM-2-induced tail-flick inhibition, respectively, while EM-2 (70 nM) pretreatment for 1 h caused 4.3- and 4.5-folds shift to the right for EM-2- and EM-1-induced tail-flick inhibition, respectively.
Negative_regulation (inhibition) of EM-1-induced in EM-2 associated with tail-flick
3) Confidence 0.33 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12932813 Disease Relevance 0 Pain Relevance 0.58
Five microM of quinine inhibited the EM/NEM and CD/NCD O-dealkylase activities by approximately 80%.
Negative_regulation (inhibited) of EM associated with codeine
4) Confidence 0.02 Published 1997 Journal Biochem. Pharmacol. Section Abstract Doc Link 9105413 Disease Relevance 0 Pain Relevance 0.91
When testing rabbit antirat CYP2D1, 2E1, 2C11, and 3A2 antibodies, only the antiCYP2D1 antibody inhibited the EM/NEM and CD/NCD O-dealkylase activities significantly.
Negative_regulation (inhibited) of EM associated with codeine
5) Confidence 0.02 Published 1997 Journal Biochem. Pharmacol. Section Abstract Doc Link 9105413 Disease Relevance 0 Pain Relevance 0.88

General Comments

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