INT68811

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2008
Negated 4
Speculated 2
Reported most in Abstract
Documents 19
Total Number 22
Disease Relevance 3.67
Pain Relevance 15.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
nucleus accumbens 6
hypothalamus 2
spinal cord 2
masseter 2
striatum 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 351 100.00 Very High Very High Very High
opioid receptor 137 100.00 Very High Very High Very High
Morphine 61 99.80 Very High Very High Very High
Opioid 23 99.72 Very High Very High Very High
Ventral tegmentum 12 99.68 Very High Very High Very High
Nucleus accumbens 8 99.68 Very High Very High Very High
Spinal cord 8 99.60 Very High Very High Very High
Immobilon 10 99.52 Very High Very High Very High
Inflammation 7 99.50 Very High Very High Very High
Substantia nigra 6 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 22 99.82 Very High Very High Very High
Aids-related Complex 3 99.60 Very High Very High Very High
INFLAMMATION 4 99.50 Very High Very High Very High
Repression 56 96.80 Very High Very High Very High
Myalgia 2 95.68 Very High Very High Very High
Sprains And Strains 2 87.84 High High
Cv Unclassified Under Development 5 83.52 Quite High
Disease 16 77.16 Quite High
Targeted Disruption 14 70.64 Quite High
Neurodegenerative Disease 4 40.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously we reported that Oprm1 transcription is regulated by a cis-acting single strand DNA sequence in the mouse Oprm1 promoter through the binding of PCBP1 (17, 19).
Regulation (regulated) of Transcription (transcription) of Oprm1
1) Confidence 0.61 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0
No significant differences in construct activity were found between untreated and morphine-treated BE(2)-C or Neuro-2a cells, suggesting that morphine does not regulate transcription of Oprm.
Neg (not) Regulation (regulate) of Transcription (transcription) of Oprm in Neuro-2a associated with morphine
2) Confidence 0.54 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16644048 Disease Relevance 0.15 Pain Relevance 0.47
The behavioral differences in response to morphine seen in CREB(alphaDelta) mutant mice are not due to changes in mu opioid receptor (MOR) mRNA expression, as the CREB deletion has no effect on baseline MOR mRNA in three of the brain regions involved in mediating these behaviors: the ventral tegmental area (VTA), nucleus accumbens (NAc), and hypothalamus.
Regulation (changes) of Transcription (expression) of MOR in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, mu opioid receptor and morphine
3) Confidence 0.53 Published 2005 Journal Brain Res. Section Abstract Doc Link 15680959 Disease Relevance 0 Pain Relevance 1.26
Together, the A-to-C change at MOR 5'-UTR decreases Sp1 binding and MOR gene transcription, which could underlie the reduced morphine expression in CXBK mice.
Regulation (underlie) of Transcription (transcription) of MOR gene associated with opioid receptor and morphine
4) Confidence 0.43 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.61
To that end, we studied the influence of NE on mu-opioid receptor (MOR) mRNA expression and MOR mediated G-protein signaling.
Regulation (influence) of Transcription (expression) of MOR associated with opioid receptor
5) Confidence 0.42 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17698254 Disease Relevance 0.14 Pain Relevance 1.04
To that end, we studied the influence of NE on mu-opioid receptor (MOR) mRNA expression and MOR mediated G-protein signaling.
Regulation (influence) of Transcription (expression) of mu-opioid receptor associated with opioid receptor
6) Confidence 0.42 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17698254 Disease Relevance 0.14 Pain Relevance 1.04
The behavioral differences in response to morphine seen in CREB(alphaDelta) mutant mice are not due to changes in mu opioid receptor (MOR) mRNA expression, as the CREB deletion has no effect on baseline MOR mRNA in three of the brain regions involved in mediating these behaviors: the ventral tegmental area (VTA), nucleus accumbens (NAc), and hypothalamus.
Regulation (changes) of Transcription (expression) of mu opioid receptor in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, mu opioid receptor and morphine
7) Confidence 0.39 Published 2005 Journal Brain Res. Section Abstract Doc Link 15680959 Disease Relevance 0 Pain Relevance 1.26
In this study, we demonstrated that Sp3 transcription factor represses the MOR gene expression by binding to a GC box adjacent to NRSE and by interacting with NRSF providing evidence that there is another level of complexity in regulating the MOR transcription.
Regulation (regulating) of Transcription (transcription) of MOR associated with mu opioid receptor
8) Confidence 0.38 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.60 Pain Relevance 0.18
The mouse MOR transcript was amplified with primer set P2Ss (5?
Regulation (amplified) of Transcription (transcript) of MOR associated with mu opioid receptor
9) Confidence 0.38 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.17
Mithramycin A up-regulates the endogenous MOR transcription
Regulation (regulates) of Transcription (transcription) of MOR associated with mu opioid receptor
10) Confidence 0.34 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.22
Results indicate that etorphine induced dose-dependent regulation of muOR density, DYN-2 proteins, and mRNA abundance in mouse spinal cord.
Regulation (regulation) of Transcription (abundance) of muOR density in spinal cord associated with spinal cord and immobilon
11) Confidence 0.27 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.91
Our earlier studies showed that mouse Oprm1 transcription was regulated by a cis-acting single strand DNA sequence that was essential for the activity of the mouse Oprm1 promoter through the binding of ?
Regulation (regulated) of Transcription (transcription) of Oprm1
12) Confidence 0.27 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0.05
High intrinsic efficacy agonists (e.g., etorphine), but not lower intrinsic efficacy agonists (e.g., morphine), produce mu-opioid receptor down-regulation and can alter the abundance of mu-opioid receptor mRNA.
Regulation (alter) of Transcription (abundance) of mu-opioid receptor associated with agonist, opioid receptor, morphine and immobilon
13) Confidence 0.26 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.16
These data suggest that stress-induced alteration of MOR-encoding mRNA expression in the VTA may be involved in the consequences of social defeat stress.
Regulation (alteration) of Transcription (expression) of MOR-encoding associated with stress, ventral tegmentum and opioid receptor
14) Confidence 0.25 Published 1999 Journal Neuroreport Section Abstract Doc Link 10549815 Disease Relevance 0.60 Pain Relevance 0.87
However, in the NRSF negative PC12 cells, MOR transcript level was not affected by mithramycin A treatment (Figure 1C).
Neg (not) Regulation (affected) of Transcription (level) of MOR associated with mu opioid receptor
15) Confidence 0.23 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0 Pain Relevance 0.36
This study tested the hypothesis that stress-induced opioid peptides may have stimulative and inhibitive influence on mu opioid receptor (MOR) mRNA expression and hypothalamus.
Regulation (have) of Transcription (expression) of MOR in hypothalamus associated with stress, mu opioid receptor and opioid
16) Confidence 0.23 Published 2003 Journal Brain Res. Section Abstract Doc Link 12867258 Disease Relevance 0.50 Pain Relevance 0.42
In contrast, defeat stress was without effect on the expression of MOR-encoding mRNA in the SN.
Neg (without) Regulation (effect) of Transcription (expression) of MOR-encoding associated with stress, substantia nigra and opioid receptor
17) Confidence 0.15 Published 1999 Journal Neuroreport Section Abstract Doc Link 10549815 Disease Relevance 0.52 Pain Relevance 0.89
The aims of this project were to investigate whether inflammation in the orofacial muscle alters mu opioid receptor (MOR) mRNA and protein expressions in trigeminal ganglia (TG), and to assess the contribution of peripheral MORs under acute and inflammatory muscle pain conditions. mRNA and protein levels for MOR were quantified by reverse-transcription-polymerase chain reaction (RT-PCR) and Western blot, respectively, from the TG of naïve rats, and compared with those from the rats treated with complete Freund's adjuvant (CFA) in the masseter.
Spec (whether) Regulation (alters) of Transcription (expressions) of MOR in masseter associated with pain, inflammation, mu opioid receptor and myalgia
18) Confidence 0.14 Published 2007 Journal Neuroscience Section Abstract Doc Link 17379421 Disease Relevance 0.50 Pain Relevance 0.61
However, weak tetanization sufficient to induce LTP and ARG expression did not influence MOR mRNA levels.
Neg (not) Regulation (influence) of Transcription (levels) of MOR associated with aids-related complex, opioid receptor and long-term potentiation
19) Confidence 0.14 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16176345 Disease Relevance 0.52 Pain Relevance 0.85
To investigate the participation of the opioid system in this phenomenon, we examined the effects of acute and repeated AMPH administration on mu-opioid receptor (MOR) mRNA levels in the nucleus accumbens (NAc) and striatum (STR) of rats, by quantitative non-radioactive in situ hybridization.
Spec (examined) Regulation (effects) of Transcription (levels) of MOR in NAc associated with nucleus accumbens, opioid receptor and opioid
20) Confidence 0.10 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10350632 Disease Relevance 0 Pain Relevance 0.59

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