INT68812

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 5
Total Number 8
Disease Relevance 0.16
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
spinal cord 2
fundus 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 170 100.00 Very High Very High Very High
opioid receptor 50 100.00 Very High Very High Very High
Morphine 17 100.00 Very High Very High Very High
Spinal cord 6 99.28 Very High Very High Very High
MU agonist 4 97.76 Very High Very High Very High
Opioid 14 95.28 Very High Very High Very High
antagonist 4 94.72 High High
agonist 6 89.72 High High
opiate 2 89.36 High High
Immobilon 5 84.64 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 4 87.36 High High
Neuroblastoma 12 72.40 Quite High
Repression 16 50.00 Quite Low
Contagious Ecthyma 28 37.96 Quite Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that regulation of the MOR uORF is independent of the peptide sequence of the uORF.
Neg (independent) Regulation (independent) of Regulation (regulation) of MOR uORF associated with mu opioid receptor
1) Confidence 0.40 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0 Pain Relevance 0.10
We demonstrate novel roles as transcriptional regulators in Oprm1 regulation for hnRNP K and ?
Regulation (roles) of Regulation (regulation) of Oprm1
2) Confidence 0.39 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Abstract Doc Link PMC2494908 Disease Relevance 0.07 Pain Relevance 0.24
The effects of altered muOR levels on peripheral analgesia were then examined.
Regulation (effects) of Regulation (altered) of muOR
3) Confidence 0.27 Published 2008 Journal Anesthesiology Section Body Doc Link 18212576 Disease Relevance 0 Pain Relevance 0
Taken together, muOR regulation may depend on changes in DYN-2 abundance induced by high-efficacy opioid agonists in mouse spinal cord.
Spec (may) Regulation (depend) of Regulation (regulation) of muOR in spinal cord associated with mu agonist and spinal cord
4) Confidence 0.27 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.80
In this study, we used proteomics to identify and characterize single strand DNA-binding proteins that regulate mouse Oprm1 regulation.
Regulation (regulate) of Regulation (regulation) of Oprm1
5) Confidence 0.27 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0.04
The overall mechanisms involved in such spatial and temporal regulations of MOR have not yet been elucidated.
Regulation (involved) of Regulation (regulations) of MOR associated with mu opioid receptor
6) Confidence 0.24 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.09 Pain Relevance 0.85
Previous radioligand-binding studies have reported conflicting results concerning the effect of chronic morphine administration on the regulation of mu-opioid receptor (MOR) density.
Regulation (effect) of Regulation (regulation) of MOR associated with opioid receptor and morphine
7) Confidence 0.05 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9105683 Disease Relevance 0 Pain Relevance 0.84
We examined the effects of altering mu-opioid receptor (MOR) activity in the medial subnucleus of the tractus solitarius (mNTS) on several gastric end points including intragastric pressure (IGP), fundus tone, and the receptive relaxation reflex (RRR).
Spec (examined) Regulation (effects) of Regulation (altering) of mu-opioid receptor in fundus associated with opioid receptor
8) Confidence 0.03 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20489046 Disease Relevance 0 Pain Relevance 0.41

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