INT68813

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Context Info
Confidence 0.71
First Reported 1997
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 93
Total Number 95
Disease Relevance 20.11
Pain Relevance 57.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
NS20Y 5
DRG 5
brainstem 4
cerebellum 3
nucleus accumbens 3
Oprm1 (Mus musculus)
Oprm1 - A118G (1)
Pain Link Frequency Relevance Heat
mu opioid receptor 1423 100.00 Very High Very High Very High
opioid receptor 804 100.00 Very High Very High Very High
Opioid 498 100.00 Very High Very High Very High
endometriosis 14 99.96 Very High Very High Very High
Morphine 245 99.88 Very High Very High Very High
Spinal cord 116 99.84 Very High Very High Very High
Inflammation 288 99.80 Very High Very High Very High
Pain 351 99.68 Very High Very High Very High
Nucleus accumbens 23 99.68 Very High Very High Very High
Ventral tegmentum 21 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis (extended) 14 99.96 Very High Very High Very High
INFLAMMATION 291 99.80 Very High Very High Very High
Pain 398 99.68 Very High Very High Very High
Necrosis 12 99.56 Very High Very High Very High
Stress 102 99.54 Very High Very High Very High
Aids-related Complex 6 99.40 Very High Very High Very High
Cancer 23 99.38 Very High Very High Very High
Neuroblastoma 43 98.80 Very High Very High Very High
Targeted Disruption 427 98.40 Very High Very High Very High
Burns 91 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant time-dependent variations in the mRNA levels of the mu-opioid receptor and its binding capacity were observed in mouse brainstem.
Transcription (levels) of mu-opioid receptor in brainstem associated with medulla and opioid receptor
1) Confidence 0.71 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16109741 Disease Relevance 0.09 Pain Relevance 0.83
The distal promoter initiates Oprm1 transcription from a single initiation site located 794 bp upstream of the translation start site.
Transcription (transcription) of Oprm1
2) Confidence 0.71 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0.06 Pain Relevance 0.42
The proximal promoter initiates Oprm1 transcription from four major transcription initiation sites located in a region ranging from 291 to 268 bp upstream of the translation start site.
Transcription (transcription) of Oprm1 in proximal
3) Confidence 0.71 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0.05 Pain Relevance 0.23
Previously we reported that Oprm1 transcription is regulated by a cis-acting single strand DNA sequence in the mouse Oprm1 promoter through the binding of PCBP1 (17, 19).
Transcription (transcription) of Oprm1
4) Confidence 0.71 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0
Inhibition of PARP-1's catalytic domain with 3-aminobenzamide increased endogenous MOR mRNA levels in cultured NS20Y cells, suggesting that automodification of PARP-1 regulates MOR transcription.
Transcription (transcription) of MOR in NS20Y associated with mu opioid receptor
5) Confidence 0.70 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18266974 Disease Relevance 0 Pain Relevance 0.63
Under the ad libitum feeding, mRNA levels of mu-opioid receptor and its binding capacity in mouse brainstem increased around the early dark phase, following the 24-h variation in circulating glucocorticoid levels.
Transcription (levels) of mu-opioid receptor in brainstem associated with medulla and opioid receptor
6) Confidence 0.69 Published 2006 Journal J. Pharmacol. Sci. Section Abstract Doc Link 16682786 Disease Relevance 0 Pain Relevance 0.83
Surprisingly, the distribution of the mu opioid receptor (MOR) in the embryonic brain, especially in proliferative regions, is poorly defined and subject to conflicting reports.
Transcription (distribution) of MOR in embryonic brain associated with mu opioid receptor
7) Confidence 0.69 Published 2007 Journal Brain Res. Section Abstract Doc Link 17888889 Disease Relevance 0 Pain Relevance 0.47
Surprisingly, the distribution of the mu opioid receptor (MOR) in the embryonic brain, especially in proliferative regions, is poorly defined and subject to conflicting reports.
Transcription (distribution) of mu opioid receptor in embryonic brain associated with mu opioid receptor
8) Confidence 0.69 Published 2007 Journal Brain Res. Section Abstract Doc Link 17888889 Disease Relevance 0 Pain Relevance 0.47
Together, the A-to-C change at MOR 5'-UTR decreases Sp1 binding and MOR gene transcription, which could underlie the reduced morphine expression in CXBK mice.
Transcription (transcription) of MOR gene associated with opioid receptor and morphine
9) Confidence 0.68 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15562256 Disease Relevance 0 Pain Relevance 0.61
A 3' rapid amplification of cDNA ends-PCR analysis revealed that the 3' untranslated region of the C57BL/6By MOR-1 mRNA was 10 181 nucleotides transcribed from an exon.
Transcription (transcribed) of MOR-1 mRNA
10) Confidence 0.68 Published 2006 Journal Pharmacogenet. Genomics Section Body Doc Link 16708053 Disease Relevance 0 Pain Relevance 0
Intron 3 between exon 3 and exon 4 of mouse Oprm1 is about 20 kb, indicating that the RT-PCR for Oprm1 using the above sense (exon 3) and antisense (exon 4) primers produce only Oprm1 mRNA.
Transcription (produce) of Oprm1
11) Confidence 0.68 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0
Primers specific to total Oprm1 mRNA were as follows: 5?
Transcription (specific) of Oprm1
12) Confidence 0.68 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Body Doc Link PMC2494908 Disease Relevance 0 Pain Relevance 0
To that end, we studied the influence of NE on mu-opioid receptor (MOR) mRNA expression and MOR mediated G-protein signaling.
Transcription (expression) of MOR associated with opioid receptor
13) Confidence 0.67 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17698254 Disease Relevance 0.14 Pain Relevance 1.03
To that end, we studied the influence of NE on mu-opioid receptor (MOR) mRNA expression and MOR mediated G-protein signaling.
Transcription (expression) of mu-opioid receptor associated with opioid receptor
14) Confidence 0.67 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17698254 Disease Relevance 0.14 Pain Relevance 1.04
When the PU.1 gene is disrupted as in PU.1 knock-out mice and using small interfering RNA-based strategy in RAW264.7 cells, the transcription of the endogenous target MOR gene is increased significantly.
Transcription (transcription) of MOR gene associated with targeted disruption and opioid receptor
15) Confidence 0.67 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14998994 Disease Relevance 0.27 Pain Relevance 0.62
We previously reported that the 34-bp cis-acting element of the mouse micro opioid receptor (MOR) gene represses transcription of the MOR gene from the distal promoter.
Transcription (transcription) of MOR gene associated with opioid receptor
16) Confidence 0.67 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14998994 Disease Relevance 0 Pain Relevance 0.41
The pharmacological effects of opioid drugs are mediated mainly by the mu-opioid receptor (MOR), which is encoded by an mRNA transcript named MOR1.
Transcription (transcript) of MOR associated with opioid receptor and opioid
17) Confidence 0.63 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 15879516 Disease Relevance 0 Pain Relevance 0.39
No significant differences in construct activity were found between untreated and morphine-treated BE(2)-C or Neuro-2a cells, suggesting that morphine does not regulate transcription of Oprm.
Transcription (transcription) of Oprm in Neuro-2a associated with morphine
18) Confidence 0.63 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16644048 Disease Relevance 0.15 Pain Relevance 0.47
We found that the presence of the uORF region suppressed translation without changing MOR transcription levels.
Transcription (transcription) of MOR associated with mu opioid receptor
19) Confidence 0.61 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0 Pain Relevance 0.36
Whether these uORFs can regulate the translation of the MOR transcripts was examined in this study.
Transcription (transcripts) of MOR associated with mu opioid receptor
20) Confidence 0.61 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0.19 Pain Relevance 0.24

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