INT68814

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 2008
Negated 5
Speculated 0
Reported most in Abstract
Documents 16
Total Number 18
Disease Relevance 2.72
Pain Relevance 13.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
hippocampus 5
hypothalamus 4
frontal cortex 4
liver 2
brain 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 61 100.00 Very High Very High Very High
Opioid 24 100.00 Very High Very High Very High
mu opioid receptor 13 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
cocaine 44 99.98 Very High Very High Very High
Morphine 39 99.86 Very High Very High Very High
Nucleus accumbens 18 99.84 Very High Very High Very High
Enkephalin 7 99.80 Very High Very High Very High
withdrawal 21 99.48 Very High Very High Very High
Ventral tegmentum 5 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 11 99.98 Very High Very High Very High
Urological Neuroanatomy 12 99.68 Very High Very High Very High
Diabetes Mellitus 10 99.68 Very High Very High Very High
Targeted Disruption 1 90.36 High High
Hyperglycemia 2 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the mRNA level of opioid mu-receptor in the liver markedly increased in STZ-diabetic rats compared to normal rats.
Positive_regulation (increased) of Transcription (level) of mu-receptor in liver associated with diabetes mellitus and opioid
1) Confidence 0.60 Published 2001 Journal Horm. Metab. Res. Section Abstract Doc Link 11544560 Disease Relevance 0.87 Pain Relevance 0.87
The mRNA species for MOR1, MOR1A and MOR1B were readily detectable and distributed widely throughout the rat CNS, with levels of MOR1 and MOR1A mRNA being overall greater than for MOR1B.
Positive_regulation (distributed) of Transcription (detectable) of MOR1A
2) Confidence 0.50 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.29
The mRNA species for MOR1, MOR1A and MOR1B were readily detectable and distributed widely throughout the rat CNS, with levels of MOR1 and MOR1A mRNA being overall greater than for MOR1B.
Positive_regulation (distributed) of Transcription (detectable) of MOR1
3) Confidence 0.50 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.29
The mRNA species for MOR1, MOR1A and MOR1B were readily detectable and distributed widely throughout the rat CNS, with levels of MOR1 and MOR1A mRNA being overall greater than for MOR1B.
Positive_regulation (distributed) of Transcription (detectable) of MOR1B
4) Confidence 0.50 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18005002 Disease Relevance 0 Pain Relevance 0.29
An increase in mu-opioid receptor (MOP) mRNA levels was observed in the frontal cortex of 3-h withdrawn rats.
Positive_regulation (increase) of Transcription (levels) of mu-opioid receptor in frontal cortex associated with urological neuroanatomy and opioid receptor
5) Confidence 0.48 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950784 Disease Relevance 0.17 Pain Relevance 0.53
We observed an increase in mu-opioid receptor mRNA levels in the ventromedial nucleus of the hypothalamus (VMH) and arcuate nucleus (ARN) after 48 h of 10 microg of 17-beta-estradiol-3-benzoate treatment when compared to OVX females.
Positive_regulation (increase) of Transcription (levels) of mu-opioid receptor in hypothalamus associated with opioid receptor
6) Confidence 0.47 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9221910 Disease Relevance 0 Pain Relevance 0.40
Acute "binge" cocaine increases mu-opioid receptor mRNA levels in areas of the rat mesolimbic mesocortical dopamine system.
Positive_regulation (increases) of Transcription (levels) of mu-opioid receptor associated with dopamine, opioid receptor and cocaine
7) Confidence 0.46 Published 1999 Journal Brain Res. Bull. Section Title Doc Link 10210176 Disease Relevance 0.07 Pain Relevance 0.70
Acute binge cocaine administration significantly increased mu-opioid receptor mRNA levels in the frontal cortex, nucleus accumbens, and amygdala, but not in the caudate-putamen, thalamus, hippocampus, and hypothalamus.
Neg (not) Positive_regulation (increased) of Transcription (levels) of mu-opioid receptor in hippocampus associated with nucleus accumbens, urological neuroanatomy, hippocampus, thalamus, opioid receptor, amygdala and cocaine
8) Confidence 0.46 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10210176 Disease Relevance 0.10 Pain Relevance 0.76
Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex.
Positive_regulation (increases) of Transcription (levels) of mu-opioid receptor in frontal cortex associated with urological neuroanatomy, enkephalin, opioid receptor, withdrawal and cocaine
9) Confidence 0.45 Published 2005 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 15950784 Disease Relevance 0.19 Pain Relevance 0.65
The results showed that ith morphine could increase the expression of mu-opioid receptor mRNA.
Positive_regulation (increase) of Transcription (expression) of mu-opioid receptor associated with opioid receptor and morphine
10) Confidence 0.44 Published 2000 Journal Acupunct Electrother Res Section Abstract Doc Link 10830970 Disease Relevance 0.26 Pain Relevance 0.98
Social defeat stress increases expression of mu-opioid receptor mRNA in rat ventral tegmental area.
Positive_regulation (increases) of Transcription (expression) of mu-opioid receptor in ventral associated with stress, ventral tegmentum and opioid receptor
11) Confidence 0.40 Published 1999 Journal Neuroreport Section Title Doc Link 10549815 Disease Relevance 0.51 Pain Relevance 0.90
Transient upregulation of mu opioid receptor mRNA levels in nucleus accumbens during chronic cocaine administration.
Positive_regulation (upregulation) of Transcription (levels) of mu opioid receptor in nucleus accumbens associated with nucleus accumbens, mu opioid receptor, enkephalin and cocaine
12) Confidence 0.36 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 9673791 Disease Relevance 0 Pain Relevance 1.23
Chronic morphine and naltrexone fail to modify mu-opioid receptor mRNA levels in the rat brain.
Neg (fail) Positive_regulation (modify) of Transcription (levels) of mu-opioid receptor in brain associated with enkephalin, opioid receptor and morphine
13) Confidence 0.35 Published 1997 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9105683 Disease Relevance 0 Pain Relevance 1.13
Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal.
Positive_regulation (enhanced) of in striatum Transcription (levels) of Mu opioid receptor in lateral associated with mu opioid receptor, withdrawal and morphine
14) Confidence 0.31 Published 2006 Journal J. Endocrinol. Section Title Doc Link 17065397 Disease Relevance 0.13 Pain Relevance 1.14
Acute binge cocaine administration significantly increased mu-opioid receptor mRNA levels in the frontal cortex, nucleus accumbens, and amygdala, but not in the caudate-putamen, thalamus, hippocampus, and hypothalamus.
Neg (not) Positive_regulation (increased) of in thalamus Transcription (levels) of mu-opioid receptor in hippocampus associated with nucleus accumbens, urological neuroanatomy, hippocampus, thalamus, opioid receptor, amygdala and cocaine
15) Confidence 0.16 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10210176 Disease Relevance 0.10 Pain Relevance 0.76
Acute binge cocaine administration significantly increased mu-opioid receptor mRNA levels in the frontal cortex, nucleus accumbens, and amygdala, but not in the caudate-putamen, thalamus, hippocampus, and hypothalamus.
Neg (not) Positive_regulation (increased) of in hypothalamus Transcription (levels) of mu-opioid receptor in hippocampus associated with nucleus accumbens, urological neuroanatomy, hippocampus, thalamus, opioid receptor, amygdala and cocaine
16) Confidence 0.16 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10210176 Disease Relevance 0.10 Pain Relevance 0.76
Acute binge cocaine administration significantly increased mu-opioid receptor mRNA levels in the frontal cortex, nucleus accumbens, and amygdala, but not in the caudate-putamen, thalamus, hippocampus, and hypothalamus.
Neg (not) Positive_regulation (increased) of in caudate-putamen Transcription (levels) of mu-opioid receptor in hippocampus associated with nucleus accumbens, urological neuroanatomy, hippocampus, thalamus, opioid receptor, amygdala and cocaine
17) Confidence 0.16 Published 1999 Journal Brain Res. Bull. Section Abstract Doc Link 10210176 Disease Relevance 0.10 Pain Relevance 0.76
Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal.
Positive_regulation (enhanced) of in hypothalamus Transcription (levels) of Mu opioid receptor in lateral associated with mu opioid receptor, withdrawal and morphine
18) Confidence 0.10 Published 2006 Journal J. Endocrinol. Section Title Doc Link 17065397 Disease Relevance 0.13 Pain Relevance 1.14

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