INT6882

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Context Info
Confidence 0.47
First Reported 1986
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.97
Pain Relevance 3.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Adrb2) signal transduction (Adrb2) plasma membrane (Adrb2)
nucleus (Adrb2) cytoplasm (Adrb2) signal transducer activity (Adrb2)
Anatomy Link Frequency
body 1
Adrb2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 8 100.00 Very High Very High Very High
Dopamine 2 100.00 Very High Very High Very High
agonist 10 99.96 Very High Very High Very High
tricyclic antidepressant 5 99.92 Very High Very High Very High
Potency 2 99.70 Very High Very High Very High
lidocaine 24 99.54 Very High Very High Very High
interstitial cystitis 10 98.92 Very High Very High Very High
Clonidine 4 97.24 Very High Very High Very High
Neurotransmitter 1 94.52 High High
opiate 2 75.20 Quite High
Disease Link Frequency Relevance Heat
Interstitial Cystitis 10 98.92 Very High Very High Very High
Congenital Anomalies 2 97.76 Very High Very High Very High
Hypothermia 1 97.04 Very High Very High Very High
Aggression 3 96.52 Very High Very High Very High
Coronary Artery Disease 39 94.32 High High
Stroke 4 76.96 Quite High
Myocardial Infarction 19 75.20 Quite High
Death 5 74.48 Quite High
INFLAMMATION 11 51.60 Quite High
Nicotine Addiction 2 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interaction between beta-adrenoceptor agonists and alpha 1-adrenergic system.
beta-adrenoceptor Binding (Interaction) of associated with agonist
1) Confidence 0.47 Published 1986 Journal Pol J Pharmacol Pharm Section Title Doc Link 2883639 Disease Relevance 0.27 Pain Relevance 0.46
ADRB2 haplotypes were not associated with the primary outcome (data not shown).
ADRB2 Binding (associated) of
2) Confidence 0.29 Published 2008 Journal J Transl Med Section Body Doc Link PMC2329599 Disease Relevance 0.75 Pain Relevance 0.03
Pretreatment with the alpha 2-adrenoceptor antagonist, atipamezole; the beta-adrenoceptor antagonist, propranolol; the dopamine antagonist, haloperidol; or the benzodiazepine receptor antagonist, flumazenil had no intrinsic effects on core body temperature nor did they interact significantly with the hypothermic effects of caffeine.
beta-adrenoceptor Binding (interact) of in body associated with dopamine and antagonist
3) Confidence 0.24 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1334837 Disease Relevance 0.10 Pain Relevance 0.65
Efficacy of tricyclic antidepressant is associated with beta2-adrenoceptor genotype in patients with interstitial cystitis.
beta2-adrenoceptor Binding (associated) of associated with interstitial cystitis and tricyclic antidepressant
4) Confidence 0.00 Published 2006 Journal Biomed. Res. Section Title Doc Link 16971769 Disease Relevance 0.75 Pain Relevance 0.96
Lidocaine potency at inhibiting beta 2AR binding also increased with increasing pH; thus, there was limited benefit (in terms of increasing binding to beta 2ARs) to increasing pH when lidocaine was present.
beta 2AR Binding (binding) of associated with lidocaine and potency
5) Confidence 0.00 Published 1995 Journal Chest Section Abstract Doc Link 7587445 Disease Relevance 0 Pain Relevance 1.02
We tested whether beta 2AR binding is influenced by pH or the antiarrhythmic drug lidocaine, and whether pH might influence the interaction of lidocaine with beta 2ARs.
beta 2AR Spec (whether) Binding (binding) of associated with lidocaine
6) Confidence 0.00 Published 1995 Journal Chest Section Abstract Doc Link 7587445 Disease Relevance 0.10 Pain Relevance 0.43

General Comments

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