INT68846

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Context Info
Confidence 0.32
First Reported 1997
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 10.10
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tfrc) peptidase activity (Tfrc) mitochondrion (Tfrc)
extracellular region (Tfrc) cytoplasmic membrane-bounded vesicle (Tfrc) plasma membrane (Tfrc)
Anatomy Link Frequency
astrocyte 3
T cell 2
bone marrow 1
erythroblasts 1
fibroblast 1
Tfrc (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 15 99.10 Very High Very High Very High
cytokine 34 99.04 Very High Very High Very High
Arthritis 33 98.56 Very High Very High Very High
fluoxetine 4 98.36 Very High Very High Very High
Inflammatory response 15 96.12 Very High Very High Very High
Inflammation 96 95.20 Very High Very High Very High
aspirin 41 94.32 High High
Central nervous system 16 91.96 High High
fibrosis 66 87.60 High High
rheumatoid arthritis 107 87.36 High High
Disease Link Frequency Relevance Heat
Cancer 80 100.00 Very High Very High Very High
Infection 20 99.08 Very High Very High Very High
Arthritis 35 98.56 Very High Very High Very High
Diabetes Mellitus 318 98.40 Very High Very High Very High
Autoimmune Disease 42 97.84 Very High Very High Very High
Drug Induced Neurotoxicity 9 96.08 Very High Very High Very High
INFLAMMATION 110 95.94 Very High Very High Very High
Mixed Connective Tissue Disorder 14 94.16 High High
Viral Infection 4 92.52 High High
Disease 236 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Likewise, CD69, CD71, as markers for T cell activation, as well as CD152 (CTLA-4) were found to be expressed only at low levels, and with no difference between patients and controls.
Neg (no) Gene_expression (expressed) of CD71 in T cell
1) Confidence 0.32 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.37 Pain Relevance 0
Primary astrocyte cultures from these same TR APOE mice show LPS-mediated innate immune activation that is greatest with TR APOE2, less with TR APOE3, and least with TR APOE4 that correlates with NF-?
Gene_expression (cultures) of TR in astrocyte
2) Confidence 0.25 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.35 Pain Relevance 0.08
Primary astrocyte cultures from these same TR APOE mice show LPS-mediated innate immune activation that is greatest with TR APOE2, less with TR APOE3, and least with TR APOE4 that correlates with NF-?
Gene_expression (these) of TR in astrocyte
3) Confidence 0.25 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.35 Pain Relevance 0.08
In contrast, TR APOE2 astrocytes had the highest NF-?
Gene_expression (astrocytes) of TR in astrocytes
4) Confidence 0.25 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.10 Pain Relevance 0.03
A lower level of CD25, CD71, CD69, and HLA-DR antigen expression was found in patients at all observation times and in pre-T1D subjects after administration of 1 µg/ml of PHA showed a significantly reduced expression of CD69 and CD71 [65].
Gene_expression (expression) of CD71 associated with diabetes mellitus
5) Confidence 0.24 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 1.00 Pain Relevance 0.13
A lower level of CD25, CD71, CD69, and HLA-DR antigen expression was found in patients at all observation times and in pre-T1D subjects after administration of 1 µg/ml of PHA showed a significantly reduced expression of CD69 and CD71 [65].
Gene_expression (expression) of CD71 associated with diabetes mellitus
6) Confidence 0.24 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.93 Pain Relevance 0.12
In order to study a role of some mediators of pro-inflammatory response in this process, presently, we investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells, stably transfected with mouse mammary tumor virus promoter (LMCAT cells).
Gene_expression (transfected) of mammary tumor virus promoter in fibroblast associated with inflammatory response, cancer and fluoxetine
7) Confidence 0.23 Published 2005 Journal Pharmacol Rep Section Abstract Doc Link 16129923 Disease Relevance 0.50 Pain Relevance 0.61
This has been achieved in adult mice using monoclonal antibodies (mAb) specific to the TfR conjugated to bacterial ?
Gene_expression (conjugated) of TfR
8) Confidence 0.16 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.20 Pain Relevance 0.16
This has been achieved in adult mice using monoclonal antibodies (mAb) specific to the TfR conjugated to bacterial ?
Gene_expression (specific) of TfR
9) Confidence 0.16 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.20 Pain Relevance 0.16
Additionally, the TfR was used to deliver plasmid DNA encoding a lysosomal enzyme, ?
Gene_expression (used) of TfR
10) Confidence 0.16 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.18 Pain Relevance 0.16
NSAIDs were shown to inhibit T cell proliferation, expression of activation-related molecules such as CD25 and CD71, and the production of cytokines such as IL-2, IFN-?
Gene_expression (expression) of CD71 in T cell associated with cinod and cytokine
11) Confidence 0.13 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.32 Pain Relevance 0.99
However, its activity is markedly enhanced when co-expressed with the liganded TR-LBD [Mahajan and Samuels, 2000].
Gene_expression (expressed) of TR-LBD
12) Confidence 0.11 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
The solubilization of non-raft proteins in these samples was complete, as the transferrin receptor (which does not associate with lipid rafts and thus served as a marker of Triton X-100-soluble membranes) was not detected in any of these samples (data not shown).


Neg (not) Gene_expression (detected) of transferrin receptor
13) Confidence 0.08 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0
While these cells maintain a highly activated phenotype indicated by high expression of CD69, transferrin receptor and HLA-DR, they are nonetheless hyporesponsive to antigenic stimulation [8-10].
Gene_expression (expression) of transferrin receptor
14) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453771 Disease Relevance 0.70 Pain Relevance 0.31
Subsequent to the initial description, the same group reported after in vitro expansion the SVF derived cells had surface marker expression similar to bone marrow derived MSC, comprising of positive for CD29, CD44, CD71, CD90, CD105/SH2, and SH3 and lacking CD31, CD34, and CD45 expression [24].
Gene_expression (comprising) of CD71 in bone marrow
15) Confidence 0.06 Published 2009 Journal J Transl Med Section Body Doc Link PMC2679713 Disease Relevance 0.38 Pain Relevance 0.03
No differences were found among the different groups of subjects in regard to the expression of CD25 and CD71.
Gene_expression (expression) of CD71
16) Confidence 0.05 Published 1997 Journal Circulation Section Body Doc Link 9107167 Disease Relevance 0.13 Pain Relevance 0
Expression of CoAA enhances activation by a number of transcription factors including NF-kB, CREB, AP-1, TR, ER and GR.
Gene_expression (Expression) of TR
17) Confidence 0.05 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Normal populations of BM cells were found mostly within the CD45+ gate, apart from the erythroblasts, which were CD45 negative, but CD71 and CD235a positive in FC.
Neg (negative) Gene_expression (negative) of CD71 in erythroblasts
18) Confidence 0.04 Published 2010 Journal Clin Exp Metastasis Section Body Doc Link PMC2910884 Disease Relevance 0.90 Pain Relevance 0
Both early and short-lived (interleukin-2 receptor [IL-2R], alpha-chain CD25, and transferrin receptor CD71) and late antigen (HLA-DR) expression were investigated by flow cytometric analysis.
Gene_expression (expression) of CD71
19) Confidence 0.04 Published 1997 Journal Circulation Section Body Doc Link 9107167 Disease Relevance 0.18 Pain Relevance 0
Normal BM cells were found mostly within the CD45+ gate (neutrophils—B, lymphocytes—C), apart from the erythroblasts, which were CD45 negative, but also CD71 and CD235a positive in FC
Gene_expression (positive) of CD71 in neutrophils
20) Confidence 0.04 Published 2010 Journal Clin Exp Metastasis Section Body Doc Link PMC2910884 Disease Relevance 1.15 Pain Relevance 0

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