INT68850

Context Info Confidence 0.19 First Reported 1997 Last Reported 2004 Negated 0 Speculated 0 Reported most in Title Documents 2 Total Number 2 Disease Relevance 0.19 Pain Relevance 0.43

cytosol (NQO1) small molecule metabolic process (NQO1) oxidoreductase activity (NQO1) cellular nitrogen compound metabolic process (NQO1) cytoplasm (NQO1)

Anatomy Link Frequency spinal 1 NQO1 (Homo sapiens)

Pain Link Frequency Relevance Heat spinal dorsal horn 7 98.92 qutenza 2 98.40 Hyperalgesia 1 54.96 central sensitization 1 54.28

Disease Link Frequency Relevance Heat Targeted Disruption 2 75.00 Hyperalgesia 1 54.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Inhibitors of glucose uptake and glycolysis, the ubiquinone redox cycle inhibitors, capsaicin and resiniferatoxin, the flavin centre inhibitor, diphenyleneiodonium, and the NQO1 inhibitor, dicoumarol, all inhibited oxygen consumption by HL60rho(0) cells.

Negative_regulation (inhibitor) of NQO1 associated with qutenza

1) Confidence 0.19 Published 2004 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15178469 Disease Relevance 0.14 Pain Relevance 0.10

Localization of NADPH-diaphorase containing neurons in the spinal dorsal horn and spinal sensory ganglia of the turtle Chrysemys d'orbigny.

Negative_regulation (Localization) of NADPH-diaphorase in spinal associated with spinal dorsal horn

2) Confidence 0.09 Published 1997 Journal Exp Brain Res Section Title Doc Link 9108212 Disease Relevance 0.05 Pain Relevance 0.33

General Comments

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