INT68856

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 10.68
Pain Relevance 10.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
macrophages 2
cleavage 2
nerve 1
spinal cord 1
arm 1


Pain Term Frequency Confidence Heat
Glutamate receptor 7 100.00 Very High Very High Very High
potassium channel 15 100.00 Very High Very High Very High
adenocard 3 100.00 Very High Very High Very High
Opioid 4 100.00 Very High Very High Very High
gABA 3 100.00 Very High Very High Very High
agonist 37 100.00 Very High Very High Very High
Cannabinoid 5 100.00 Very High Very High Very High
Inflammation 114 99.52 Very High Very High Very High
IPN 6 99.34 Very High Very High Very High
Calcitonin gene-related peptide 62 99.34 Very High Very High Very High
Disease Term Frequency Confidence Heat
INFLAMMATION 138 99.52 Very High Very High Very High
Inflammatory Pain 6 99.34 Very High Very High Very High
Pain 46 99.16 Very High Very High Very High
Hypertension 5 99.04 Very High Very High Very High
Hypersensitivity 5 98.72 Very High Very High Very High
Hyperalgesia 12 98.40 Very High Very High Very High
Rheumatoid Arthritis 33 98.40 Very High Very High Very High
Arthritis 65 98.00 Very High Very High Very High
Pressure And Volume Under Development 22 96.40 Very High Very High Very High
Cluster Headache 8 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: Kinins mediate pathophysiological processes related to hypertension, pain, and inflammation through the activation of two G-protein-coupled receptors, named B(1) and B(2).
Positive_regulation (activation) of G-protein-coupled receptors associated with pain, inflammation and hypertension
1) Confidence 0.67 Published 2008 Journal Diabetes Section Abstract Doc Link 18332096 Disease Relevance 0.45 Pain Relevance 0.19
Proteinase-activated receptors (PARs) are a family of G-protein-coupled receptors that are activated by endogenous serine proteinases that cleave the N-terminal domain of the receptor unmasking a "tethered ligand" sequence.
Positive_regulation (activated) of G-protein-coupled receptors
2) Confidence 0.67 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17921188 Disease Relevance 0.34 Pain Relevance 0.42
Together these findings demonstrate that S1P can regulate the excitability of small diameter sensory neurons by acting as an external paracrine-type ligand through activation of G-protein-coupled receptors and thus may contribute to the hypersensitivity during inflammation.
Positive_regulation (activation) of G-protein-coupled receptors in external associated with inflammation and hypersensitivity
3) Confidence 0.67 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16723416 Disease Relevance 0.29 Pain Relevance 0.18
Anaesthetic-induced preconditioning and ischaemic preconditioning share many fundamental steps, including activation of G-protein-coupled receptors, multiple protein kinases and ATP-sensitive potassium channels (K(ATP) channels).
Positive_regulation (activation) of G-protein-coupled receptors associated with potassium channel
4) Confidence 0.67 Published 2003 Journal Br J Anaesth Section Abstract Doc Link 14504159 Disease Relevance 0 Pain Relevance 0.40
A diverse spectrum of physiological and pathological actions attributed to local kinin production is a consequence of the activation of G-protein-coupled receptors (GPCRs).
Positive_regulation (activation) of G-protein-coupled receptors
5) Confidence 0.67 Published 2003 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 12667103 Disease Relevance 0 Pain Relevance 0.21
The amplitude of the RA-mechanosensitive current in nociceptors has also been shown to be modulated by activation of G-protein-coupled receptors as well as through nerve growth factor signalling (Di Castro et al, 2006; Lechner and Lewin, 2009; Lechner et al, 2009).
Positive_regulation (activation) of G-protein-coupled receptors in nerve associated with nerve growth factor, nociceptor and rheumatoid arthritis
6) Confidence 0.67 Published 2010 Journal EMBO J Section Body Doc Link PMC2810375 Disease Relevance 0.31 Pain Relevance 0.19
The effects of physiological changes in membrane voltage on transporter function were assessed by the activation of G-protein-coupled receptors.
Positive_regulation (activation) of G-protein-coupled receptors
7) Confidence 0.67 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11567046 Disease Relevance 0 Pain Relevance 0.78
Kinins are vasoactive peptides and pro-inflammatory pain mediators which act through the activation of two G-protein-coupled receptors (R), named B1 and B2.
Positive_regulation (activation) of G-protein-coupled receptors associated with ipn
8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.82 Pain Relevance 0.82
Method for identifying ligands activating either excitatory or inhibitory G-protein-coupled receptors by functional coexpression in Xenopus oocytes.
Positive_regulation (activating) of G-protein-coupled receptors in oocytes
9) Confidence 0.67 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 9168947 Disease Relevance 0 Pain Relevance 0.13
Proteinase-activated receptors (PARs) are G-protein-coupled receptors that are activated by the proteolytic cleavage of their N-terminal domain.
Positive_regulation (activated) of G-protein-coupled receptors in cleavage
10) Confidence 0.67 Published 2008 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18924448 Disease Relevance 0 Pain Relevance 0
Cellular responses induced by opsonized zymosan differ from those induced by chemoattractant-activated G-protein-coupled receptors.
Positive_regulation (activated) of G-protein-coupled receptors
11) Confidence 0.49 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.08 Pain Relevance 0.04
Therefore, a transient [Ca2+]c elevation is not in any way linked to the generation of a NADPH oxidase-activating signal from G-protein-coupled receptors.
Positive_regulation (activating) of G-protein-coupled receptors
12) Confidence 0.49 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Proteinase activated receptors (PARs) are a newly identified family of G-protein-coupled receptors that are activated by proteinases released into tissues during inflammation.
Positive_regulation (activated) of G-protein-coupled receptors associated with inflammation
13) Confidence 0.49 Published 2009 Journal Inflamm. Res. Section Abstract Doc Link 19184346 Disease Relevance 0.63 Pain Relevance 0.39
Such inflammatory effects may be exerted by activation of G-protein–coupled receptors such as cysteinyl leukotrienes receptors, which mediate the constriction of vascular smooth muscle cells.37 By the way, D'Andrea et al38 detected an increase in cysteinyl leukotrienes receptors gene expression on macrophages in periprosthetic capsular tissue of patients affected by capsular contracture.39
Positive_regulation (activation) of G-protein-coupled receptors in macrophages associated with inflammation and contracture
14) Confidence 0.49 Published 2010 Journal Eplasty Section Body Doc Link PMC2948451 Disease Relevance 0.66 Pain Relevance 0.25
These findings correlate in vivo NMDA receptor tyrosine phosphorylation with the development and maintenance of inflammatory hyperalgesia and suggest that signal transduction upstream to NR2B tyrosine phosphorylation involves G-protein-coupled receptors and PKC and Src family protein tyrosine kinases.
Positive_regulation (involves) of G-protein-coupled receptors associated with hyperalgesia, inflammation and nmda receptor
15) Confidence 0.49 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12122079 Disease Relevance 0.86 Pain Relevance 1.12
Prostanoids exert their actions by acting on a family of G-protein-coupled receptors.
Positive_regulation (acting) of G-protein-coupled receptors
16) Confidence 0.49 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607267 Disease Relevance 0.18 Pain Relevance 0.14
CGRP is a 37 amino acid peptide that activates adenylyl cyclase and protein kinase A through G-protein-coupled receptors, including the CGRP1 receptor for which selective antagonists are available [18-21].
Positive_regulation (activates) of G-protein-coupled receptors associated with antagonist and calcitonin gene-related peptide
17) Confidence 0.45 Published 2006 Journal Mol Pain Section Body Doc Link PMC1592081 Disease Relevance 1.11 Pain Relevance 1.86
A cluster of gene-encoding G-protein-coupled receptors that bind and are activated by trace amines was identified in the long arm of chromosome 6q23.
Positive_regulation (activated) of G-protein-coupled receptors in arm
18) Confidence 0.45 Published 2004 Journal Neurol. Sci. Section Abstract Doc Link 15549560 Disease Relevance 0.82 Pain Relevance 0.87
The main pharmacological effects of marijuana, as well as synthetic and endogenous cannabinoids, are mediated through G-protein-coupled receptors (GPCRs), including CB(1) and CB(2) receptors.
Positive_regulation (mediated) of G-protein-coupled receptors associated with cannabinoid
19) Confidence 0.45 Published 2010 Journal Br. J. Pharmacol. Section Abstract Doc Link 20590557 Disease Relevance 0.56 Pain Relevance 0.34
Protease-activated receptors (PARs) are a family of four G-protein-coupled receptors (PAR-1 to PAR-4) activated by the proteolytic cleavage of their N-terminal extracellular domain.
Positive_regulation (activated) of G-protein-coupled receptors in cleavage
20) Confidence 0.45 Published 2005 Journal Expert Opin. Ther. Targets Section Abstract Doc Link 16185159 Disease Relevance 0.27 Pain Relevance 0.11

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