INT68857

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Context Info
Confidence 0.34
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.51
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rxfp2) plasma membrane (Rxfp2)
Anatomy Link Frequency
sensory neurons 1
Rxfp2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 6 98.82 Very High Very High Very High
antinociception 1 97.80 Very High Very High Very High
Antinociceptive 1 97.40 Very High Very High Very High
dorsal root ganglion 7 96.44 Very High Very High Very High
Neuropeptide 1 94.24 High High
Dopamine 3 93.96 High High
Serotonin 6 93.36 High High
Bile 61 93.28 High High
GABAergic 48 92.88 High High
antagonist 42 89.60 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 4 99.48 Very High Very High Very High
INFLAMMATION 1 96.60 Very High Very High Very High
Ganglion Cysts 7 96.44 Very High Very High Very High
Heart Rate Under Development 111 83.60 Quite High
Fistula 19 81.32 Quite High
Injury 1 75.00 Quite High
Sinus Arrhythmia 3 73.24 Quite High
Depression 12 49.92 Quite Low
Targeted Disruption 1 34.16 Quite Low
Disease 12 29.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased levels of RGS3 and RGS4 in injured sensory neurons is likely to result in an increased GPCR sensitivity, and therefore contribute to alterations in cellular function seen after such lesions.
Positive_regulation (increased) of GPCR in sensory neurons
1) Confidence 0.34 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14550772 Disease Relevance 0.43 Pain Relevance 0.30
Its effects are mediated through G-protein-coupled receptors (GPCR) for which only a single type has been cloned, GAL receptor 1 (GALR1).
Positive_regulation (mediated) of GPCR
2) Confidence 0.25 Published 1997 Journal FEBS Lett. Section Abstract Doc Link 9108306 Disease Relevance 0 Pain Relevance 0.14
Activation of g-protein coupled receptors (GPCR) alters these inputs, but the functional consequence is largely unknown.
Positive_regulation (Activation) of GPCR
3) Confidence 0.17 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2964734 Disease Relevance 0.05 Pain Relevance 0.22
N-arachidonoyl glycine is an endogenous arachidonoyl amide that activates the orphan G protein-coupled receptor (GPCR) GPR18 in a pertussis toxin (PTX)-sensitive manner and produces antinociceptive and antiinflammatory effects.
Positive_regulation (activates) of GPCR associated with inflammation, bordatella infection and antinociceptive
4) Confidence 0.17 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18424551 Disease Relevance 0.20 Pain Relevance 0.09
-opioid or neurokinin-1 receptors within the NA decreases HR whereas activation of opioid-receptor like receptor-1 increases HR, demonstrating that activation of some GPCR can differentially alter the tonic level of HR [18-21].
Positive_regulation (activation) of GPCR associated with opioid
5) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2964734 Disease Relevance 0.23 Pain Relevance 0.51
Furthermore, we wished to establish how activation of the 5-HT1A GPCR affects tonic and reflex control of HR and what ionotropic interactions this might involve.


Positive_regulation (activation) of GPCR
6) Confidence 0.15 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2964734 Disease Relevance 0.41 Pain Relevance 0.35
In the present study, we provide evidence that TCA, through activation of GPCR(s) and the PI3K/PDK-1/AKT pathway (insulin signaling pathway), can regulate gluconeogenic genes.
Positive_regulation (activation) of GPCR
7) Confidence 0.14 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.20 Pain Relevance 0.25

General Comments

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