INT68882

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Context Info
Confidence 0.23
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 4.33
Pain Relevance 6.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
neurons 2
microglia 2
dendrites 1
glial cells 1
endothelial cells 1
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 14 100.00 Very High Very High Very High
substance P 9 100.00 Very High Very High Very High
Neuropathic pain 47 99.92 Very High Very High Very High
Dorsal horn neuron 7 99.76 Very High Very High Very High
potassium channel 48 99.74 Very High Very High Very High
Pain 108 99.50 Very High Very High Very High
Inflammation 195 99.08 Very High Very High Very High
cytokine 37 98.20 Very High Very High Very High
Antinociceptive 37 97.92 Very High Very High Very High
Arthritis 15 97.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 135 99.92 Very High Very High Very High
Pain 133 99.50 Very High Very High Very High
INFLAMMATION 220 99.08 Very High Very High Very High
Injury 31 98.94 Very High Very High Very High
Arthritis 14 97.88 Very High Very High Very High
Intractable Pain 1 96.04 Very High Very High Very High
Apoptosis 39 86.24 High High
Embryonal Carcinoma 21 84.80 Quite High
Inflammatory Pain 50 82.60 Quite High
Hyperalgesia 58 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, LPS-activated endothelial cells have been shown able to secrete ATP, via P2X7 receptors, and to release IL-l?
P2X7 Binding (receptors) of in endothelial cells
1) Confidence 0.23 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.32 Pain Relevance 0.25
In addition, the P2X7 receptor-protein complex comprises several distinct identified proteins, with different regulatory capacities [35], indicating a complexity for the P2X7 receptor functions.
P2X7 receptor Binding (complexity) of
2) Confidence 0.23 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.42 Pain Relevance 0.36
Recent data indicate that, in response to ATP binding, the P2X7 receptors facilitate cation channel activation, non-specific pore formation, rapid changes in plasma membrane morphology (blebbing) and secretion of IL-1?
P2X7 Binding (binding) of in pore
3) Confidence 0.22 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.31 Pain Relevance 0.41
This is an interesting finding, given that the KATP channel and P2X7 are each a ligand-gated ion channel wherein the endogenous ligand is ATP.
P2X7 Binding (ligand) of associated with potassium channel
4) Confidence 0.19 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.22 Pain Relevance 0.54
Many of the published adamantane amide analogs were found to possess poor metabolic stability and pharmacokinetic characteristics; however, the indazole-containing compound 8 (P2X7 pA2?
P2X7 Binding (compound) of
5) Confidence 0.16 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.15
Further investigation of the linker portion between the phenyl and adamantane revealed that reversing the connectivity of the amide also provided analogs with potent P2X7 activity such as 7 (P2X7 pA2?
P2X7 Binding (activity) of
6) Confidence 0.16 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.14
8.3) and 8 (P2X7 pA2?
P2X7 Binding (8.3) of
7) Confidence 0.16 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.14
Such approaches are feasible, since these compounds mostly have higher affinities to some P2 receptor subtypes than to other ones.
P2 receptor Binding (affinities) of
8) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.14 Pain Relevance 0.20
Second, a nonvesicular mechanism of ATP release could be observed through gap junction hemichannels, ATP-binding cassette proteins, P2X7 receptor pores in glial cells, and via chloride channels [98–101].
P2X7 receptor Binding (binding) of in glial cells
9) Confidence 0.11 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.08 Pain Relevance 0.22
ATP selectively suppresses the synthesis of the inflammatory protein microglial response factor through calcium influx via P2X7 receptors in microglia [129], which also leads to enhancement of interferon-?
P2X7 Binding (receptors) of in microglia associated with inflammation
10) Confidence 0.10 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.71 Pain Relevance 0.47
The sum of effects shown for BzATP and NMDA in granule neurons indicates a new and interesting example of interaction between P2X7 and NMDA receptors.
P2X7 Binding (interaction) of in neurons associated with nmda receptor
11) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.09 Pain Relevance 0.05
P2X7 in microglia might be an essential molecule in producing cytokines, TNF-?
P2X7 Binding (microglia) of in microglia associated with cytokine
12) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 1.01 Pain Relevance 1.08
P2X7 and NMDA receptors converge on GSK3 phosphorylation in granule neurons
P2X7 Binding (receptors) of in neurons associated with nmda receptor
13) Confidence 0.07 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.16
Injection of NMDA in the cerebrospinal fluid of the rat spinal cord mimicked the changes that occur with persistent injury, and produced not only pain, but also a large-scale internalization of the substance P receptor into dorsal horn neurons, as well as structural changes in their dendrites.
P receptor Binding (internalization) of in dendrites associated with pain, injury, dorsal horn neuron, substance p and spinal cord
14) Confidence 0.06 Published 1997 Journal Nature Section Abstract Doc Link 9109489 Disease Relevance 0.91 Pain Relevance 1.69
Phosphorylation of regulatory proteins associated with P2X1 or P2X7 receptor increased the activity of the P2X receptors [51,52].
P2X7 receptor Binding (associated) of
15) Confidence 0.06 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 0.11 Pain Relevance 0.22
Interestingly, His120 in the P2X2 receptor is equivalent to Arg125 in the P2X7 receptor, which is ADP ribosylated and can lead to receptor activation (Adriouch et al., 2007), once again highlighting that this residue is close to the ATP binding site.
P2X7 receptor Binding (lead) of
16) Confidence 0.04 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2972645 Disease Relevance 0 Pain Relevance 0.08

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