INT68890

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Context Info
Confidence 0.14
First Reported 1997
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.81
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mptp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Codeine 4 27.68 Quite Low
Substantia nigra 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Neurobehavioral 3 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
dopaminergic neurodegeneration 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 77 100.00 Very High Very High Very High
Neurodegenerative Disease 9 84.64 Quite High
Alzheimer's Dementia 21 82.64 Quite High
Dementia 8 72.32 Quite High
Intellectual Impairment 2 54.88 Quite High
Disease 10 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Motor Neuron Diseases 5 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Cardiovascular Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paramagnetic relaxation experiments have been used to measure distances between the protons of bound MPTP and the heme iron, and these have been used to construct models for the position and orientation of MPTP in the active site.
MPTP Binding (bound) of associated with parkinson's disease
1) Confidence 0.14 Published 1997 Journal Biochemistry Section Abstract Doc Link 9109653 Disease Relevance 0.46 Pain Relevance 0
The K(m) for formation of this product (130 microM) is in agreement with the dissociation constants for MPTP binding to the enzyme determined by optical and nuclear magnetic resonance (NMR) spectroscopy.
MPTP Spec (determined) Binding (binding) of associated with parkinson's disease
2) Confidence 0.12 Published 1997 Journal Biochemistry Section Abstract Doc Link 9109653 Disease Relevance 0.32 Pain Relevance 0
For PD the first recognized environmental cause, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), was identified in epidemiologic studies of drug abusers.
MPTP Binding (recognized) of associated with parkinson's disease
3) Confidence 0.04 Published 2005 Journal Environ Health Perspect Section Abstract Doc Link PMC1280407 Disease Relevance 1.03 Pain Relevance 0

General Comments

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