INT68913

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Context Info
Confidence 0.76
First Reported 1997
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 55
Total Number 62
Disease Relevance 38.99
Pain Relevance 15.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd14) plasma membrane (Cd14) response to stress (Cd14)
Anatomy Link Frequency
monocytes 14
lymphocyte 4
microglia 4
macrophages 2
plasma 2
Cd14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 41 99.92 Very High Very High Very High
cytokine 157 99.84 Very High Very High Very High
Snapping jaw 60 99.78 Very High Very High Very High
Angina 90 99.52 Very High Very High Very High
Acupuncture 120 99.48 Very High Very High Very High
MU agonist 1 99.46 Very High Very High Very High
rheumatoid arthritis 120 99.30 Very High Very High Very High
Inflammatory response 17 99.28 Very High Very High Very High
Cancer pain 98 99.12 Very High Very High Very High
Inflammation 329 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 542 100.00 Very High Very High Very High
Necrosis 47 100.00 Very High Very High Very High
Fibromyalgia 18 99.96 Very High Very High Very High
Magnesium Deficiency 1 99.84 Very High Very High Very High
Temporomandibular Joint Syndrome 59 99.78 Very High Very High Very High
Stable Angina Pectoris 6 99.52 Very High Very High Very High
Bone Cancer 111 99.32 Very High Very High Very High
Cv General 3 Under Development 83 99.32 Very High Very High Very High
Rheumatoid Arthritis 152 99.30 Very High Very High Very High
Adhesions 42 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intestinal and cardiac inflammatory response shows enhanced endotoxin receptor (CD14) expression in magnesium deficiency.
Gene_expression (expression) of CD14 associated with inflammatory response, inflammation and magnesium deficiency
1) Confidence 0.76 Published 2005 Journal Mol. Cell. Biochem. Section Title Doc Link 16180088 Disease Relevance 0.38 Pain Relevance 0.36
In addition, expression of CD14, a receptor for lipopolysaccharide (LPS), on the peripheral and peritoneal monocyte population was analysed.
Spec (analysed) Gene_expression (expression) of CD14 in monocyte
2) Confidence 0.73 Published 2003 Journal Nephrol. Dial. Transplant. Section Body Doc Link 12897108 Disease Relevance 0.26 Pain Relevance 0
In contrast to bacterial peritonitis, we observed no increase in CD14 expression on the peripheral and peritoneal macrophages on the day of presentation and during the follow-up period.
Gene_expression (expression) of CD14 in peritoneal macrophages
3) Confidence 0.73 Published 2003 Journal Nephrol. Dial. Transplant. Section Body Doc Link 12897108 Disease Relevance 0.16 Pain Relevance 0
Removing endogenous E2 through OVX reduced CFA induced TMJ inflammation, whereas CFA increased the number of TMJ monocytes expressing the CD14 receptor equally in all groups irrespective of plasma E2 levels.
Gene_expression (expressing) of CD14 in monocytes associated with snapping jaw and inflammation
4) Confidence 0.67 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 16153820 Disease Relevance 2.29 Pain Relevance 1.35
The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-alpha, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression.
Gene_expression (expression) of CD14 in macrophage associated with necrosis and cancer
5) Confidence 0.60 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.37 Pain Relevance 0.20
Flow cytometrical analysis revealed that PPF pretreatment showed no modulatory effect on the LPS-upregulated CD14 expression on hepatocytes.
Gene_expression (expression) of CD14 in hepatocytes
6) Confidence 0.60 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.32 Pain Relevance 0.16
Because no increase in the expression of the LPS receptor CD14 could be observed, the increased peritoneal leucocyte count is probably not caused by LPS or LPS-like (possibly peptidoglycan-like) contamination.


Gene_expression (expression) of CD14 in leucocyte
7) Confidence 0.57 Published 2003 Journal Nephrol. Dial. Transplant. Section Body Doc Link 12897108 Disease Relevance 0 Pain Relevance 0
Recently it was reported that soluble CD14 levels tended to be higher in H. pylori positives than in H. pylori negatives [19].
Gene_expression (levels) of CD14
8) Confidence 0.56 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266053 Disease Relevance 1.00 Pain Relevance 0.42
The TT homozygote has been associated with increased circulating soluble CD14 levels and a higher density of the monocyte CD14 receptor [22].
Gene_expression (levels) of CD14 in monocyte
9) Confidence 0.56 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266053 Disease Relevance 0.64 Pain Relevance 0.36
A two- to three-fold increase in the mRNA expression levels of microglial activation markers CD11b and CD14 was observed in bone cancer pain rats at days 6 and 12 after inoculation (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).
Gene_expression (expression) of CD14 associated with cancer pain and bone cancer
10) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.68 Pain Relevance 0.58
Decreased expression of TLR4 was coincident with decreased expression of the microglial activation markers CD11b (48% in IBCP group; 39% in WBCP group) and CD14 (43%; 30%)(n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).
Gene_expression (expression) of CD14
11) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.45 Pain Relevance 0.50
Expression markers specific for dendritic cells (such as CD14, CD86, CD83 and HLA-DR) were assessed by flow cytometry before and after addition of TNF- ?.


Gene_expression (Expression) of CD14 in CD86
12) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.14 Pain Relevance 0.04
Phenotypical expression of the generated DCs were analyzed to determine the expression level of CD14, CD86, CD83 and HLA-DR.
Spec (analyzed) Gene_expression (expression) of CD14 in DCs
13) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2829084 Disease Relevance 0.96 Pain Relevance 0.11
An attractive hypothesis for WAY-169916-mediated activity in the spleen involves the downregulation of LBP and CD14 expression on monocytes and macrophages, resulting in a diminished immune response and ultimately resulting in the observed decreases in MMP9, IL1R2, chemokine-like factor 1, S100A8, and S100A9 through the repression of NF-?
Gene_expression (expression) of CD14 in macrophages associated with chemokine and repression
14) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 0.31 Pain Relevance 0.16
(Supplemental material, Table S1 shows the effect of different doses of cytokines on the expression of CD 14, CD 86, CD 83 and HLA-DR in CD14 derived DCs).
Gene_expression (expression) of CD14 associated with cytokine
15) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.41 Pain Relevance 0.05
Several genes that have been implicated in the pathogenesis of RA that were regulated by WAY-169916 include LBS binding protein (LBP), CD14, MMP-9, IL1R2, S100A8, and S100A9.
Gene_expression (include) of CD14 associated with metalloproteinase and rheumatoid arthritis
16) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 0.22 Pain Relevance 0.13
M) suppressed CD14 expression.
Gene_expression (expression) of CD14
17) Confidence 0.35 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.76 Pain Relevance 0.05
M induced CD14 expression (Fig. 3).
Gene_expression (expression) of CD14
18) Confidence 0.35 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.77 Pain Relevance 0.05
His diagnosis was then changed to CMML-2 and pleural infiltration due to leukemic cells expressing CD13, CD14 and CD33.
Gene_expression (expressing) of CD14 associated with chronic myelomonocytic leukemia
19) Confidence 0.35 Published 2005 Journal Rinsho Ketsueki Section Abstract Doc Link 16447718 Disease Relevance 1.38 Pain Relevance 0.09
FS cells express CD14, which binds the LPS/LPS-binding protein complex and Toll-like receptor type 4, which transduces the LPS signal (689).
Gene_expression (express) of CD14
20) Confidence 0.35 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.37 Pain Relevance 0.35

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