INT68913

Context Info Confidence 0.76 First Reported 1997 Last Reported 2010 Negated 1 Speculated 5 Reported most in Body Documents 55 Total Number 62 Disease Relevance 38.99 Pain Relevance 15.67

extracellular space (Cd14) plasma membrane (Cd14) response to stress (Cd14)

Anatomy Link Frequency monocytes 14 lymphocyte 4 microglia 4 macrophages 2 plasma 2 Cd14 (Rattus norvegicus)

Pain Link Frequency Relevance Heat metalloproteinase 41 99.92 cytokine 157 99.84 Snapping jaw 60 99.78 Angina 90 99.52 Acupuncture 120 99.48 MU agonist 1 99.46 rheumatoid arthritis 120 99.30 Inflammatory response 17 99.28 Cancer pain 98 99.12 Inflammation 329 98.96

Disease Link Frequency Relevance Heat Cancer 542 100.00 Necrosis 47 100.00 Fibromyalgia 18 99.96 Magnesium Deficiency 1 99.84 Temporomandibular Joint Syndrome 59 99.78 Stable Angina Pectoris 6 99.52 Bone Cancer 111 99.32 Cv General 3 Under Development 83 99.32 Rheumatoid Arthritis 152 99.30 Adhesions 42 99.30

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Intestinal and cardiac inflammatory response shows enhanced endotoxin receptor (CD14) expression in magnesium deficiency.

Gene_expression (expression) of CD14 associated with inflammatory response, inflammation and magnesium deficiency

1) Confidence 0.76 Published 2005 Journal Mol. Cell. Biochem. Section Title Doc Link 16180088 Disease Relevance 0.38 Pain Relevance 0.36

In addition, expression of CD14, a receptor for lipopolysaccharide (LPS), on the peripheral and peritoneal monocyte population was analysed.

Spec (analysed) Gene_expression (expression) of CD14 in monocyte

2) Confidence 0.73 Published 2003 Journal Nephrol. Dial. Transplant. Section Body Doc Link 12897108 Disease Relevance 0.26 Pain Relevance 0

In contrast to bacterial peritonitis, we observed no increase in CD14 expression on the peripheral and peritoneal macrophages on the day of presentation and during the follow-up period.

Gene_expression (expression) of CD14 in peritoneal macrophages

3) Confidence 0.73 Published 2003 Journal Nephrol. Dial. Transplant. Section Body Doc Link 12897108 Disease Relevance 0.16 Pain Relevance 0

Removing endogenous E2 through OVX reduced CFA induced TMJ inflammation, whereas CFA increased the number of TMJ monocytes expressing the CD14 receptor equally in all groups irrespective of plasma E2 levels.

Gene_expression (expressing) of CD14 in monocytes associated with snapping jaw and inflammation

4) Confidence 0.67 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 16153820 Disease Relevance 2.29 Pain Relevance 1.35

The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-alpha, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression.

Gene_expression (expression) of CD14 in macrophage associated with necrosis and cancer

5) Confidence 0.60 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.37 Pain Relevance 0.20

Flow cytometrical analysis revealed that PPF pretreatment showed no modulatory effect on the LPS-upregulated CD14 expression on hepatocytes.

Gene_expression (expression) of CD14 in hepatocytes

6) Confidence 0.60 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.32 Pain Relevance 0.16

Because no increase in the expression of the LPS receptor CD14 could be observed, the increased peritoneal leucocyte count is probably not caused by LPS or LPS-like (possibly peptidoglycan-like) contamination.

Gene_expression (expression) of CD14 in leucocyte

7) Confidence 0.57 Published 2003 Journal Nephrol. Dial. Transplant. Section Body Doc Link 12897108 Disease Relevance 0 Pain Relevance 0

Recently it was reported that soluble CD14 levels tended to be higher in H. pylori positives than in H. pylori negatives [19].

Gene_expression (levels) of CD14

8) Confidence 0.56 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266053 Disease Relevance 1.00 Pain Relevance 0.42

The TT homozygote has been associated with increased circulating soluble CD14 levels and a higher density of the monocyte CD14 receptor [22].

Gene_expression (levels) of CD14 in monocyte

9) Confidence 0.56 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266053 Disease Relevance 0.64 Pain Relevance 0.36

A two- to three-fold increase in the mRNA expression levels of microglial activation markers CD11b and CD14 was observed in bone cancer pain rats at days 6 and 12 after inoculation (n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).

Gene_expression (expression) of CD14 associated with cancer pain and bone cancer

10) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.68 Pain Relevance 0.58

Decreased expression of TLR4 was coincident with decreased expression of the microglial activation markers CD11b (48% in IBCP group; 39% in WBCP group) and CD14 (43%; 30%)(n = 4, ANOVA1w, P < 0.01, post hoc Dunnett testing).

Gene_expression (expression) of CD14

11) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2819998 Disease Relevance 0.45 Pain Relevance 0.50

Expression markers specific for dendritic cells (such as CD14, CD86, CD83 and HLA-DR) were assessed by flow cytometry before and after addition of TNF- ?.

Gene_expression (Expression) of CD14 in CD86

12) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.14 Pain Relevance 0.04

Phenotypical expression of the generated DCs were analyzed to determine the expression level of CD14, CD86, CD83 and HLA-DR.

Spec (analyzed) Gene_expression (expression) of CD14 in DCs

13) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2829084 Disease Relevance 0.96 Pain Relevance 0.11

An attractive hypothesis for WAY-169916-mediated activity in the spleen involves the downregulation of LBP and CD14 expression on monocytes and macrophages, resulting in a diminished immune response and ultimately resulting in the observed decreases in MMP9, IL1R2, chemokine-like factor 1, S100A8, and S100A9 through the repression of NF-?

Gene_expression (expression) of CD14 in macrophages associated with chemokine and repression

14) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 0.31 Pain Relevance 0.16

(Supplemental material, Table S1 shows the effect of different doses of cytokines on the expression of CD 14, CD 86, CD 83 and HLA-DR in CD14 derived DCs).

Gene_expression (expression) of CD14 associated with cytokine

15) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.41 Pain Relevance 0.05

Several genes that have been implicated in the pathogenesis of RA that were regulated by WAY-169916 include LBS binding protein (LBP), CD14, MMP-9, IL1R2, S100A8, and S100A9.

Gene_expression (include) of CD14 associated with metalloproteinase and rheumatoid arthritis

16) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174937 Disease Relevance 0.22 Pain Relevance 0.13

M) suppressed CD14 expression.

Gene_expression (expression) of CD14

17) Confidence 0.35 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.76 Pain Relevance 0.05

M induced CD14 expression (Fig. 3).

Gene_expression (expression) of CD14

18) Confidence 0.35 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2964465 Disease Relevance 0.77 Pain Relevance 0.05

His diagnosis was then changed to CMML-2 and pleural infiltration due to leukemic cells expressing CD13, CD14 and CD33.

Gene_expression (expressing) of CD14 associated with chronic myelomonocytic leukemia

19) Confidence 0.35 Published 2005 Journal Rinsho Ketsueki Section Abstract Doc Link 16447718 Disease Relevance 1.38 Pain Relevance 0.09

FS cells express CD14, which binds the LPS/LPS-binding protein complex and Toll-like receptor type 4, which transduces the LPS signal (689).

Gene_expression (express) of CD14

20) Confidence 0.35 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.37 Pain Relevance 0.35

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