INT6892

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Context Info
Confidence 0.60
First Reported 1992
Last Reported 2008
Negated 1
Speculated 3
Reported most in Abstract
Documents 9
Total Number 12
Disease Relevance 1.32
Pain Relevance 7.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1b) cytoplasm (Htr1b) signal transducer activity (Htr1b)
Anatomy Link Frequency
nerve 2
neurons 1
brain 1
frontal cortex 1
Htr1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 48 100.00 Very High Very High Very High
fluoxetine 34 100.00 Very High Very High Very High
Dopamine 15 100.00 Very High Very High Very High
Serotonin 15 100.00 Very High Very High Very High
noradrenaline 10 100.00 Very High Very High Very High
GABAergic 54 99.84 Very High Very High Very High
Periaqueductal grey 110 98.36 Very High Very High Very High
Ventral tegmentum 3 98.00 Very High Very High Very High
Sumatriptan 87 97.92 Very High Very High Very High
sSRI 17 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 118 100.00 Very High Very High Very High
Depression 4 88.96 High High
Hypertension 2 75.00 Quite High
Hypotension 2 75.00 Quite High
Sleep Disorders 1 59.80 Quite High
Pressure Volume 2 Under Development 1 52.40 Quite High
Pain 18 41.64 Quite Low
Headache 20 25.80 Quite Low
Nociception 4 5.00 Very Low Very Low Very Low
Vomiting 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences.
Regulation (Effects) of 5-HT1B in brain associated with fluoxetine
1) Confidence 0.60 Published 2004 Journal J. Neurosci. Methods Section Title Doc Link 15589343 Disease Relevance 0.14 Pain Relevance 0.61
In radioligand binding experiments, eugenosedin-A had significant binding affinities on alpha1/alpha2, beta1, 5-HT1B and 5-HT2A receptors.
Regulation (affinities) of 5-HT1B
2) Confidence 0.60 Published 2004 Journal Pharmacology Section Abstract Doc Link 15118348 Disease Relevance 0.20 Pain Relevance 0.17
The present data also do not suggest the involvement of 5-HT3 mechanisms, but that D-16949 produces its discriminative stimulus effects in the rat primarily via agonistic actions at 5-HT1B receptors.
Regulation (produces) of 5-HT1B
3) Confidence 0.44 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1335050 Disease Relevance 0.06 Pain Relevance 0.59
The present study has demonstrated that functional 5-HT1A, 5-HT1B and 5-HT1D receptors are present on GABAergic nerve terminals within the PAG.
Regulation (present) of 5-HT1B in nerve associated with periaqueductal grey and gabaergic
4) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.37 Pain Relevance 1.06
Taken all together, these results suggest that serotonin 5-HT1B receptors significantly contribute to the control of spiking of the rat GP neurons, and that the 5-HT1B receptors exerting this control are most likely localized in the striato-pallidal pathway.
Regulation (control) of 5-HT1B in neurons associated with serotonin
5) Confidence 0.44 Published 2005 Journal Brain Res. Section Abstract Doc Link 15862532 Disease Relevance 0 Pain Relevance 0.29
The aim of the present study was to investigate effects of a 5-HT1A antagonist (WAY 100635), 5-HT1B antagonists (SB 216641 and GR 127935) or pindolol, given in combination with paroxetine or fluoxetine (SSRIs), in the forced swimming test in rats (Porsolt test).
Spec (investigate) Regulation (effects) of 5-HT1B associated with antagonist, ssri and fluoxetine
6) Confidence 0.44 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866716 Disease Relevance 0.09 Pain Relevance 0.70
Modulation of dialysate levels of dopamine, noradrenaline, and serotonin (5-HT) in the frontal cortex of freely-moving rats by (-)-pindolol alone and in association with 5-HT reuptake inhibitors: comparative roles of beta-adrenergic, 5-HT1A, and 5-HT1B receptors.

(-)-Pindolol, which possesses significant affinity for 5-HT1A, 5-HT1B, and beta 1/2-adrenergic receptors (AR)s, dose-dependently increased extracellular levels of dopamine (DA) and noradrenaline (NAD) versus 5-HT, in dialysates of the frontal cortex (FCX), but not accumbens and striatum, of freely-moving rats.

Regulation (Modulation) of 5-HT1B in frontal cortex associated with dopamine, noradrenaline, urological neuroanatomy and serotonin
7) Confidence 0.44 Published 1999 Journal Neuropsychopharmacology Section Title Doc Link 10432475 Disease Relevance 0.39 Pain Relevance 0.82
These results indicate that both 5-HT1A and 5-HT1B/1D receptors, which function in the rat as inhibitory somatodendritic and nerve terminal autoreceptors, independently regulate hippocampal 5-HT synthesis and must be simultaneously blocked to prevent the inhibition of 5-HT synthesis by selective serotonin reuptake inhibitors which increase 5-HT availability at both nerve terminals in hippocampus and 5-HT cell bodies in the raphe nuclei.
Regulation (regulate) of 5-HT1B in nerve associated with hippocampus, raphe and ssri
8) Confidence 0.44 Published 1999 Journal Synapse Section Abstract Doc Link 10025679 Disease Relevance 0 Pain Relevance 0.70
We also examined the contribution of 5-HT1B and 5-HT1D receptors to the inhibition produced by sumatriptan by pre-incubating slices in 5-HT1B and 5-HT1D antagonists.
Spec (examined) Regulation (contribution) of 5-HT1B associated with sumatriptan and antagonist
9) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.07 Pain Relevance 0.93
The aim of the study was to investigate the participation of 5-HT1B receptors in the serotonergic modulation of striatal dopaminergic transmission.
Spec (investigate) Regulation (participation) of 5-HT1B
10) Confidence 0.26 Published 1999 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9933149 Disease Relevance 0 Pain Relevance 0.44
Chronic treatments had no effect on presynaptic 5-HT1B autoreceptors, functionally evaluated by measuring 5-HT1B-mediated inhibition of depolarization-induced [3H]5-HT release from cortical and hippocampal synaptosomes.
Neg (no) Regulation (effect) of 5-HT1B
11) Confidence 0.25 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9228186 Disease Relevance 0 Pain Relevance 0.45
Furthermore, released 5-HT is taken up by the 5-HT transporter and may be under the influence of 5-HT1B and 5-HT1D autoreceptors.
Regulation (influence) of 5-HT1B
12) Confidence 0.12 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 9025111 Disease Relevance 0 Pain Relevance 0.47

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