INT68926

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.02
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (ALOX5AP) endoplasmic reticulum (ALOX5AP) nucleus (ALOX5AP)
enzyme binding (ALOX5AP)
Anatomy Link Frequency
shoulder 1
skin 1
ALOX5AP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 7 98.32 Very High Very High Very High
Inflammation 81 97.32 Very High Very High Very High
anesthesia 1 89.28 High High
Osteoarthritis 44 82.12 Quite High
cytokine 5 79.48 Quite High
antagonist 14 76.60 Quite High
cINOD 10 62.68 Quite High
rheumatoid arthritis 2 59.16 Quite High
Arthritis 6 38.52 Quite Low
metalloproteinase 7 24.16 Low Low
Disease Link Frequency Relevance Heat
Calcification 36 99.44 Very High Very High Very High
Injury 10 99.40 Very High Very High Very High
Atherosclerosis 131 99.28 Very High Very High Very High
Burns 3 99.22 Very High Very High Very High
Disease 17 97.72 Very High Very High Very High
INFLAMMATION 89 97.32 Very High Very High Very High
Nicotine Addiction 10 96.96 Very High Very High Very High
Diabetes Mellitus 82 96.72 Very High Very High Very High
Dysesthesia 1 89.96 High High
Asthma 2 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Over the past 9 years 5 of our patients have sustained third-degree burn injuries to the skin following breast reconstruction with the TRAM flap.
flap Binding (reconstruction) of in skin associated with burns and injury
1) Confidence 0.36 Published 1997 Journal Ann Plast Surg Section Abstract Doc Link 9111891 Disease Relevance 1.08 Pain Relevance 0.09
It is likely that breast reconstruction with LDF has little or no effect on shoulder ROM in the immediate postoperative period.
LDF Binding (reconstruction) of in shoulder
2) Confidence 0.36 Published 2010 Journal Ann Plast Surg Section Abstract Doc Link 20224337 Disease Relevance 0.10 Pain Relevance 0.10
One SNP in ALOX5AP (rs10507391) was associated with CarCP in this population.
ALOX5AP Binding (associated) of
3) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0.50 Pain Relevance 0.05
In exploratory analyses, one SNP in ALOX5AP (rs10507391, P = .085, intron 1) exhibited suggestive association (P < .10).
ALOX5AP Binding (association) of
4) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
Polymorphisms within ALOX12, ALOX5, and ALOX5AP are genetically associated with subclinical atherosclerosis and with biomarkers of disease in families with type 2 diabetes.
ALOX5AP Binding (associated) of associated with diabetes mellitus, atherosclerosis and disease
5) Confidence 0.31 Published 2010 Journal Mediators of Inflammation Section Abstract Doc Link PMC2878676 Disease Relevance 1.25 Pain Relevance 0.05
Functional 5-LOX requires binding to 5-lipoxygenase-activating protein (FLAP), which helps 5-LOX binding to AA at the nuclear membrane and enhances the efficiency of leukotriene synthesis [12]. 5-LOX gene expression at the transcriptional level is regulated by several transcription factors, such as smad3/4 and vitamin D receptors [13,14].
FLAP Binding (binding) of
6) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.64 Pain Relevance 0.35
formation is via blocking FLAP activity, thus preventing cytoplasmic to
FLAP Binding (activity) of
7) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2631651 Disease Relevance 0.46 Pain Relevance 0.21
Furthermore, the corresponding residues in FLAP and LTC4S have been determined to bind to an inhibitor that was cocrystallized, or to a substrate surrogate, respectively, and hence support a high degree of conservation of the substrate/inhibitor-binding site within the MAPEG superfamily.


FLAP Spec (determined) Binding (bind) of
8) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2937957 Disease Relevance 0 Pain Relevance 0

General Comments

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