INT6894

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2011
Negated 1
Speculated 4
Reported most in Abstract
Documents 168
Total Number 172
Disease Relevance 74.07
Pain Relevance 62.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (CNR1) plasma membrane (CNR1) response to stress (CNR1)
signal transducer activity (CNR1)
Anatomy Link Frequency
brain 6
N18TG2 5
immune system 4
central nervous system 4
neurons 4
CNR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 1816 100.00 Very High Very High Very High
Cannabinoid 1492 100.00 Very High Very High Very High
Cannabinoid receptor 960 100.00 Very High Very High Very High
agonist 489 100.00 Very High Very High Very High
antagonist 416 100.00 Very High Very High Very High
Hippocampus 89 100.00 Very High Very High Very High
Central nervous system 82 100.00 Very High Very High Very High
analgesia 56 100.00 Very High Very High Very High
Opioid 43 100.00 Very High Very High Very High
antinociception 9 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2468 100.00 Very High Very High Very High
Drug Dependence 108 99.92 Very High Very High Very High
Neuroblastoma 25 99.86 Very High Very High Very High
Hepatocellular Cancer 30 99.84 Very High Very High Very High
Ileus 4 99.84 Very High Very High Very High
Fibrosis 39 99.78 Very High Very High Very High
Inflammatory Bowel Disease 258 99.60 Very High Very High Very High
Pain 401 99.56 Very High Very High Very High
Sepsis 10 99.56 Very High Very High Very High
Stomach Cancer 6 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The results of this study suggest that increased nerve fibers, which express CB1, may be related to bladder pain in PBS and urgency in IDO.
Gene_expression (express) of CB1 in bladder
1) Confidence 0.78 Published 2010 Journal Urology Section Body Doc Link 20346490 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To study the expression of cannabinoid receptor 1 (CB1) in human urinary bladder hypersensitivity and overactivity disorders, and correlate changes with symptoms.
Gene_expression (expression) of cannabinoid receptor in urinary bladder associated with cannabinoid receptor and hypersensitivity
2) Confidence 0.78 Published 2010 Journal Urology Section Abstract Doc Link 20346490 Disease Relevance 0.26 Pain Relevance 0.42
OBJECTIVE: To study the expression of cannabinoid receptor 1 (CB1) in human urinary bladder hypersensitivity and overactivity disorders, and correlate changes with symptoms.
Gene_expression (expression) of CB1 in urinary bladder associated with cannabinoid receptor and hypersensitivity
3) Confidence 0.78 Published 2010 Journal Urology Section Abstract Doc Link 20346490 Disease Relevance 0.26 Pain Relevance 0.42
CB1 receptors are expressed in the motivational circuitry of the brain and modulate drug seeking.
Gene_expression (expressed) of CB1 in brain
4) Confidence 0.78 Published 2005 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 15992935 Disease Relevance 0.32 Pain Relevance 0.31
Utilizing human embryonic kidney (HEK293) cells stably expressing the CB1R and primary cultured neurons expressing endogenous CB1R, we show that treatment with cannabinoid agonists results in CB1R degradation after endocytosis and that the G-protein-coupled receptor-associated sorting protein GASP1 plays a major role in the postendocytic sorting process.
Gene_expression (expressing) of CB1R in neurons associated with cannabinoid and agonist
5) Confidence 0.78 Published 2007 Journal FASEB J. Section Abstract Doc Link 17197383 Disease Relevance 0.08 Pain Relevance 0.54
We have investigated the pharmacology of two central human cannabinoid receptor isoforms, designated CB1 and CB1A, stably expressed in Chinese hamster ovary cell lines, designated as CHO-CB1 and CHO-CB1A, respectively.
Gene_expression (expressed) of CB1 in ovary associated with cannabinoid receptor
6) Confidence 0.78 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8768742 Disease Relevance 0 Pain Relevance 0.27
We have investigated the pharmacology of two central human cannabinoid receptor isoforms, designated CB1 and CB1A, stably expressed in Chinese hamster ovary cell lines, designated as CHO-CB1 and CHO-CB1A, respectively.
Gene_expression (expressed) of CB1A in ovary associated with cannabinoid receptor
7) Confidence 0.78 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8768742 Disease Relevance 0 Pain Relevance 0.27
Expression of the human cannabinoid CB1 receptor in these cells from the inducible Flp-In T-REx locus did not alter expression levels of the mu opioid receptor.
Gene_expression (Expression) of CB1 associated with cannabinoid and mu opioid receptor
8) Confidence 0.77 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.71
Induction of expression of the modified cannabinoid CB1 receptor did not limit DAMGO-mediated ERK1/2 MAP kinase phosphorylation and did not allow SR141716A to enhance the function of DAMGO.
Gene_expression (expression) of CB1 associated with cannabinoid
9) Confidence 0.77 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.71
In the human gastric cancer cell line, HGC-27, which express cannabinoid receptor 1 (CB1), AEA stimulated proliferation at concentrations under 1 microM, while it strongly suppressed proliferation through the induction of apoptosis at 10 microM.
Gene_expression (express) of cannabinoid receptor 1 in HGC-27 associated with cannabinoid receptor, apoptosis and stomach cancer
10) Confidence 0.77 Published 2009 Journal J. Surg. Res. Section Abstract Doc Link 19394652 Disease Relevance 0.68 Pain Relevance 0.22
In the human gastric cancer cell line, HGC-27, which express cannabinoid receptor 1 (CB1), AEA stimulated proliferation at concentrations under 1 microM, while it strongly suppressed proliferation through the induction of apoptosis at 10 microM.
Gene_expression (express) of CB1 in HGC-27 associated with cannabinoid receptor, apoptosis and stomach cancer
11) Confidence 0.77 Published 2009 Journal J. Surg. Res. Section Abstract Doc Link 19394652 Disease Relevance 0.68 Pain Relevance 0.22
The expression of TRPV1, CB1 and CB2 receptor mRNA and proteins were demonstrated by RT-PCR and polyclonal antibodies, respectively.
Gene_expression (expression) of CB1
12) Confidence 0.76 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15548432 Disease Relevance 0.09 Pain Relevance 0.43
The findings presented here demonstrate the expression of CB1, CB2 and TRPV1 receptors on cerebromicrovascular endothelial cells (HBEC).
Gene_expression (expression) of CB1 in HBEC
13) Confidence 0.76 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15548432 Disease Relevance 0.10 Pain Relevance 0.37
N18TG2 neuroblastoma cells co-express delta-opioid and CB1-cannabinoid receptors.
Gene_expression (co-express) of CB1 in N18TG2 associated with neuroblastoma, cannabinoid receptor and opioid
14) Confidence 0.75 Published 1998 Journal Brain Res. Section Abstract Doc Link 9739102 Disease Relevance 0.19 Pain Relevance 0.73
In support of this possibility, CB1 receptors, which represent the major targets for the action of cannabinoids, are abundantly expressed in certain brain regions, such as the subventricular areas, which have been involved in these processes during brain development.
Gene_expression (expressed) of CB1 in brain associated with cannabinoid
15) Confidence 0.75 Published 2004 Journal Neurotox Res Section Abstract Doc Link 15545023 Disease Relevance 0.34 Pain Relevance 0.69
Also in support of this option, CB1 receptors are transiently expressed during brain development in different group of neurons which do not contain these receptors in the adult brain.
Gene_expression (expressed) of CB1 in neurons
16) Confidence 0.75 Published 2004 Journal Neurotox Res Section Abstract Doc Link 15545023 Disease Relevance 0.32 Pain Relevance 0.54
Agonist-induced regulation of cannabinoid CB1 receptors was examined in HEK-293 cells transfected with CB1 receptors and in neuroblastoma N18TG2 cells that naturally express CB1 receptors.
Gene_expression (express) of CB1 in N18TG2 associated with neuroblastoma, cannabinoid and agonist
17) Confidence 0.75 Published 2003 Journal Brain Res. Section Abstract Doc Link 12867259 Disease Relevance 0.10 Pain Relevance 0.21
Here, we examined the co-expression of the transient receptor potential vanilloid type 1 (TRPV1) and the cannabinoid CB1/CB2 receptors together with N-acylphosphatidylethanolamine-hydrolizing phospholipase D (NAPE-PLD) and fatty acid amide hydrolase (FAAH), the two enzymes responsible of the synthesis and catabolism of anandamide respectively, in human osteoclasts.
Spec (examined) Gene_expression (co-expression) of CB1 in osteoclasts associated with cannabinoid
18) Confidence 0.75 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.10 Pain Relevance 0.19
Co-expression of TRPV1, CB1/CB2, NAPE-PLD and FAAH was found in both human osteoclast cultures and in native osteoclasts from human bone biopsies.
Gene_expression (Co-expression) of CB1 in osteoclasts
19) Confidence 0.75 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.08 Pain Relevance 0.24
Blood cells themselves are, however, a significant source of endocannabinoids [18] and this, together with the CB1-receptor expression measured on these cells indicates differences in stress-induced activation of the ECS in blood cells between individuals with and without motion sickness.
Gene_expression (expression) of CB1-receptor in blood cells associated with stress, endocannabinoid and vomiting
20) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873996 Disease Relevance 0.69 Pain Relevance 0.33

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