INT6895

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Context Info
Confidence 0.31
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.94
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Mastl) cytoskeleton (Mastl) nucleus (Mastl)
cell cycle (Mastl) cell division (Mastl) kinase activity (Mastl)
Anatomy Link Frequency
brain 1
Mastl (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 84 100.00 Very High Very High Very High
Endogenous opioid 3 99.96 Very High Very High Very High
antinociception 4 97.44 Very High Very High Very High
Cannabinoid receptor 12 97.16 Very High Very High Very High
agonist 11 96.08 Very High Very High Very High
Morphine 5 95.72 Very High Very High Very High
Antinociceptive 1 94.96 High High
Multiple sclerosis 53 93.00 High High
Acute pain 3 91.48 High High
Clonidine 1 85.12 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 10 99.08 Very High Very High Very High
Tremor 10 98.52 Very High Very High Very High
Spasticity 52 98.04 Very High Very High Very High
Multiple Sclerosis 64 93.00 High High
Experimental Autoimmune Encephalomyelitis 3 91.76 High High
Pain 17 91.48 High High
Disease 12 85.04 High High
Anxiety Disorder 1 82.44 Quite High
Arthritis 1 69.20 Quite High
Drug Dependence 2 67.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In testicular perifusions, addition of THC at a concentration of 250 ng/ml completely blocked hCG-stimulated T secretion within 30 min.
Localization (secretion) of THC
1) Confidence 0.31 Published 1987 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3033703 Disease Relevance 0 Pain Relevance 0.09
Conversely, Delta(9)-THC retained the ability to release endogenous opioids in diabetic rats and maintained significant antinociception.
Localization (release) of THC associated with antinociception, diabetes mellitus and endogenous opioid
2) Confidence 0.27 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18313663 Disease Relevance 1.10 Pain Relevance 1.46
Intravenous administration of THC and also R (+)?
Localization (administration) of THC
3) Confidence 0.14 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626929 Disease Relevance 1.24 Pain Relevance 0.67
Characterization and autoradiographic localization of the cannabinoid binding site in rat brain using [3H]11-OH-delta 9-THC-DMH.
Localization (localization) of THC-DMH in brain associated with cannabinoid
4) Confidence 0.11 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1335065 Disease Relevance 0 Pain Relevance 0.20
These are a diverse set of compounds which include dibenzopyran derivatives, such as HU210; some consists of bicyclic and tricyclic analogues of THC, which lack the central pyran ring common to the classical cannabinoid, such as CP55940; some consist of aminoalkylindoles, which are structurally very different from THC, such as Win 55212-2 (Pertwee [6]; Martin et al. [7]).
Localization (different) of THC associated with cannabinoid
5) Confidence 0.06 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220031 Disease Relevance 0.60 Pain Relevance 0.54

General Comments

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