INT68952

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 5.64
Pain Relevance 1.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PCNA) nucleoplasm (PCNA) nucleolus (PCNA)
nucleus (PCNA) DNA binding (PCNA) transcription factor binding (PCNA)
Anatomy Link Frequency
bone marrow 2
gonadal 1
testis 1
internal 1
gingival epithelium 1
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 97.48 Very High Very High Very High
Angina 8 95.00 High High
Snapping jaw 27 93.88 High High
metalloproteinase 6 89.84 High High
Inflammation 83 88.36 High High
Dopamine 2 85.92 High High
bDMF 4 79.20 Quite High
Glutamate 10 78.40 Quite High
cerebral cortex 17 78.32 Quite High
Somatostatin 2 75.52 Quite High
Disease Link Frequency Relevance Heat
Cancer 72 99.48 Very High Very High Very High
Volume Depletion And Dehydration 4 99.24 Very High Very High Very High
Hyperplasia 20 98.48 Very High Very High Very High
Adhesions 26 98.36 Very High Very High Very High
Apoptosis 48 97.76 Very High Very High Very High
Stable Angina Pectoris 7 95.00 High High
Generalized Anxiety Disorder 40 94.84 High High
Temporomandibular Joint Syndrome 27 93.88 High High
Fibrosis 4 93.88 High High
Acute Coronary Syndrome 8 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCNA Proliferating cell nuclear antigen
Localization (antigen) of PCNA
1) Confidence 0.62 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.82 Pain Relevance 0.39
Many PCNA-positive cells were localized in plaque areas, as follows: intimal hyperplasia, neovascularized lesions, lesions with macrophage clusters, and lesions near areas of disrupted internal elastic lamina.
Localization (localized) of PCNA in internal associated with hyperplasia
2) Confidence 0.61 Published 1997 Journal Hiroshima J. Med. Sci. Section Abstract Doc Link 9114565 Disease Relevance 1.44 Pain Relevance 0.59
Interestingly, there was a positive correlation between the increase in IL-6 and the increase in PCNA co-localization with Pax7 early in the post-intervention time-course.
Localization (localization) of PCNA
3) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.09 Pain Relevance 0.03
Celenligil – Nazlien et al. (2000) [47] investigated the localization of PCNA, which is a nuclear protein associated with the cell cycle in oral gingival epithelium and defined the age-related changes as to the PCNA-proliferative index (PI) in inflamed as well as healthy gingiva.
Spec (investigated) Localization (localization) of PCNA in gingival epithelium
4) Confidence 0.48 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2874215 Disease Relevance 0.62 Pain Relevance 0
Moreover, there exists a great degree of colocalization between PCNA and PKH26 around the infarct penumbra.
Localization (colocalization) of PCNA
5) Confidence 0.27 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2974740 Disease Relevance 0 Pain Relevance 0.07
In order to explore if transplanted bone marrow cells might be a part of the proliferating cells seen around the infarct areas, we carried out double labeling analysis for colocalization of PCNA (visualized with Alexa-488 conjugated secondary antibody) and PKH26.
Localization (colocalization) of PCNA in bone marrow
6) Confidence 0.25 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2974740 Disease Relevance 0.08 Pain Relevance 0
To determine the colocalization of PCNA and DCX expression with transplanted BMMCs, additional sections were subject to double fluorescent labeling for PCNA or DCX with PKH26.
Spec (determine) Localization (colocalization) of PCNA
7) Confidence 0.25 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2974740 Disease Relevance 0.10 Pain Relevance 0
Measurement of PCNA-positive cells, chymase-positive cells, and mast cells
Localization (Measurement) of PCNA in mast cells
8) Confidence 0.24 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2763124 Disease Relevance 0.34 Pain Relevance 0
Colocalization of transplanted bone marrow cells with PCNA
Localization (Colocalization) of PCNA in bone marrow
9) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2974740 Disease Relevance 0.25 Pain Relevance 0
PCNA-immunopositive cells were detected in the gonadal/mesonephros complex at day 30 (Fig. 6d) and was predominantly localised to the seminiferous cords at the later gestational ages examined.
Localization (localised) of PCNA in mesonephros
10) Confidence 0.17 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0
FBS- and PDGF-BB-stimulated intracellular Ras, MEK1/2, ERK1/2, proliferative cell nuclear antigen (PCNA), and Akt activations were significantly inhibited by lercanidipine; however, lercanidipine did not affect FBS- and PDGF-BB-induced STAT3 phosphorylation.
Localization (antigen) of PCNA
11) Confidence 0.16 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 18973813 Disease Relevance 0.40 Pain Relevance 0.15
For antigen retrieval of PCNA (mouse IgG), the sections were heated in distilled water in an autoclave for 10 minutes.
Localization (retrieval) of PCNA
12) Confidence 0.12 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912238 Disease Relevance 0 Pain Relevance 0.04
B, and PCNA were normally localized only in the synovial membrane of wild type TMJs.
Localization (localized) of PCNA
13) Confidence 0.10 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC2998788 Disease Relevance 0.71 Pain Relevance 0.39
In a second step, CD3 and PCNA were visualized with donkey anti-goat, conjugated to Alexa Fluor 594 (Molecular probes, Eugene, OR).
Localization (visualized) of PCNA
14) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886834 Disease Relevance 0 Pain Relevance 0
Integrated optical density of Western blot reaction with antiserum directed against PCNA and ?
Localization (directed) of PCNA
15) Confidence 0.09 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0.17 Pain Relevance 0.04
Proliferation marker PCNA is localized in interstitial cells of postnatal rodent testis
Localization (localized) of PCNA in testis
16) Confidence 0.09 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0.26 Pain Relevance 0
This same protocol was followed for proliferating cell nuclear antigen (PCNA), a co-factor for DNA polymerase and a convenient endogenous marker for newly proliferated cells, immunofluorescence using mouse anti-PCNA (1?
Localization (marker) of PCNA
17) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995744 Disease Relevance 0 Pain Relevance 0
PCNA proliferating cell nuclear antigen
Localization (antigen) of PCNA
18) Confidence 0.07 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC434499 Disease Relevance 0.36 Pain Relevance 0.08
PCNA-immunopositive cells were detected in the gonadal/mesonephros complex at day 30 (Fig. 6d) and was predominantly localised to the seminiferous cords at the later gestational ages examined.
Localization (localised) of PCNA in gonadal
19) Confidence 0.06 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0 Pain Relevance 0

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