INT68959

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 6
Speculated 0
Reported most in Body
Documents 34
Total Number 35
Disease Relevance 11.68
Pain Relevance 7.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger1) plasma membrane (Ptger1) signal transducer activity (Ptger1)
Anatomy Link Frequency
limb 2
stroma 1
oocytes 1
PGE2 1
paw 1
Ptger1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 135 99.70 Very High Very High Very High
Hippocampus 8 99.68 Very High Very High Very High
qutenza 267 99.28 Very High Very High Very High
agonist 99 99.20 Very High Very High Very High
adenocard 11 98.92 Very High Very High Very High
cINOD 78 98.00 Very High Very High Very High
Inflammation 212 96.88 Very High Very High Very High
withdrawal 35 94.96 High High
anesthesia 4 94.84 High High
Thermal hyperalgesia 75 93.84 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 135 99.70 Very High Very High Very High
Stress 20 99.60 Very High Very High Very High
Cancer 347 99.56 Very High Very High Very High
Targeted Disruption 39 99.54 Very High Very High Very High
Inflammatory Bowel Disease 4 99.54 Very High Very High Very High
Malignant Neoplastic Disease 220 99.52 Very High Very High Very High
Hypersensitivity 13 99.16 Very High Very High Very High
Benign Tumor 15 98.92 Very High Very High Very High
INFLAMMATION 260 96.88 Very High Very High Very High
Atherosclerosis 3 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The EP1 receptor was found to be present in the urothelium.
Gene_expression (present) of EP1
1) Confidence 0.67 Published 2008 Journal Biomed. Res. Section Abstract Doc Link 18480552 Disease Relevance 0.16 Pain Relevance 0.45
Capsaicin provided a protective action against HCl/ethanol-induced gastric lesions in wild-type (+/+) mice in an indomethacin-sensitive manner, and this action was similarly observed in EP1 (-/-) and EP3 (-/-) mice but not in the animals lacking IP receptors.
Neg (lacking) Gene_expression (lacking) of EP1 associated with qutenza
2) Confidence 0.65 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12604682 Disease Relevance 0 Pain Relevance 0.96
Male C57/BL6 mice, both wild type and animals lacking EP1, EP3, or IP receptors, were used after 18 h of fasting.
Neg (lacking) Gene_expression (lacking) of EP1
3) Confidence 0.61 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17928639 Disease Relevance 0 Pain Relevance 0.09
TC increased the mucosal PGE2 contents similarly in both wild-type and knockout mice lacking EP1 or EP3 receptors, yet the protective action of TC against HCl/ethanol was observed in both wild-type and EP3 receptor knockout mice, but not in mice lacking EP1 receptors.
Neg (lacking) Gene_expression (lacking) of EP1 associated with targeted disruption
4) Confidence 0.58 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11356942 Disease Relevance 0.32 Pain Relevance 0.28
When temperature ramps were applied to HEK293 cells expressing both TRPV1 and EP1 in the absence of PGE2, heat-evoked currents developed at 40.7 ± 0.3°C (n = 8) (Figure 2D).
Gene_expression (expressing) of EP1
5) Confidence 0.56 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.06 Pain Relevance 0.34
PGE2 receptors are classified into four subtypes, EP1, EP2, EP3, and EP4.
Gene_expression (classified) of EP1
6) Confidence 0.52 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.05 Pain Relevance 0
EP1 and EP3 messenger RNA expression predominate in the collecting duct and thick limb, respectively, where their stimulation reduces sodium chloride and water absorption, promoting natriuresis and diuresis.
Gene_expression (expression) of EP1 in limb associated with diuresis and natriuresis
7) Confidence 0.50 Published 2000 Journal Curr. Opin. Nephrol. Hypertens. Section Abstract Doc Link 10654821 Disease Relevance 0.40 Pain Relevance 0.10
Therefore, we examined whether a similar signal transduction pathway is involved in the regulation of TRPV1 responses through EP1.
Gene_expression (responses) of EP1
8) Confidence 0.48 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0 Pain Relevance 0.11
The involvement of EP1 receptors in the PGE2-induced hypersensitivity was supported by another behavioral analysis in which PGE2 caused less reduction of paw withdrawal latency in wild type mice pretreated with a specific EP1 antagonist (500 pmol/ 20 ?
Gene_expression (receptors) of EP1 in paw associated with antagonist, hypersensitivity and withdrawal
9) Confidence 0.48 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.69 Pain Relevance 0.67
Granulosa cells from monkey periovulatory follicles expressed mRNA for all 4 EP receptors, with EP1, EP2, and EP3 receptor proteins detected by immunofluorescence [8].
Gene_expression (expressed) of EP1 in Granulosa cells
10) Confidence 0.45 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
EP1 receptor protein was not detected in monkey oocytes, with little or no immunofluorescence observed after incubation with EP1 receptor antibody or EP1 receptor antibody preabsorbed with the antigenic peptide (not shown).
Neg (not) Gene_expression (detected) of EP1 receptor protein in oocytes
11) Confidence 0.45 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.03
EP1 and EP3 mRNA expression predominates in the collecting duct and thick limb, respectively, where their stimulation reduces NaCl and water absorption, promoting natriuresis and diuresis.
Gene_expression (expression) of EP1 in limb associated with diuresis and natriuresis
12) Confidence 0.44 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.31 Pain Relevance 0.04
M, 1.5 min) caused a robust increase in the magnitude of low dose (20 nM) capsaicin-activated currents in HEK293 cells co-expressing TRPV1 with EP1 (0.90 ± 0.04 fold increase, n = 9 for control (Cont.); 4.60 ± 1.03 fold, n = 17 for PGE2, p < 0.05) (Figures 2A and 2B).
Gene_expression (co-expressing) of EP1 associated with qutenza
13) Confidence 0.43 Published 2005 Journal Mol Pain Section Body Doc Link PMC1074353 Disease Relevance 0.09 Pain Relevance 0.58
Significant increases were found for the expressions of both EP1 and EP2 in AC compared to benign tumours in the present study.
Gene_expression (expressions) of EP1 associated with malignant neoplastic disease and benign tumor
14) Confidence 0.34 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.85 Pain Relevance 0.10
The cellular localization of mPGES-1 in the present study, suggested a close connection to the cells expressing EP1–2 receptors, which also support an autocrine/paracrine regulatory pathway.
Gene_expression (expressing) of EP1
15) Confidence 0.34 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 1.09 Pain Relevance 0.19
Both EP1 and EP2 were expressed in OSE, while only EP2 was present in stroma cells, an expression pattern similar to that observed for mPGES-1 (Figure 8E,F).


Gene_expression (expressed) of EP1 in stroma
16) Confidence 0.34 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.74 Pain Relevance 0
Serial sections from each tumour were stained for the expression of COX-1, COX-2, mPGES-1, EP1 and EP2.
Gene_expression (expression) of EP1 associated with cancer
17) Confidence 0.34 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1657027 Disease Relevance 0.92 Pain Relevance 0
Moreover, both studies showed that EP2 and EP3, but not EP1 or EP4, are abundantly expressed in the hippocampus or visual cortex.
Neg (not) Gene_expression (expressed) of EP1 in cortex associated with hippocampus
18) Confidence 0.33 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.17
Rabbit anti-EP1, -EP2, -EP3, and -EP4 receptor antibodies (1:200; Cayman Chemical) were used to detect EP1, EP2, EP3, and EP4 receptor protein.


Gene_expression (detect) of EP1
19) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.08 Pain Relevance 0.08
Rabbit anti-EP1, -EP2, -EP3, and -EP4 receptor antibodies (1:200; Cayman Chemical) were used to detect EP1, EP2, EP3, and EP4 receptor protein.


Gene_expression (detect) of EP1
20) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.07 Pain Relevance 0.08

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