INT68960

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 42
Total Number 52
Disease Relevance 15.75
Pain Relevance 9.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger4) plasma membrane (Ptger4) signal transducer activity (Ptger4)
Anatomy Link Frequency
cochlea 4
oocytes 4
cochlear 2
glomerulus 2
uterus 2
Ptger4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 917 100.00 Very High Very High Very High
dorsal root ganglion 81 99.84 Very High Very High Very High
Hippocampus 8 99.68 Very High Very High Very High
qutenza 156 99.42 Very High Very High Very High
Crohn's disease 86 98.46 Very High Very High Very High
antagonist 272 98.40 Very High Very High Very High
cINOD 20 98.28 Very High Very High Very High
Inflammation 141 97.92 Very High Very High Very High
Dismenorea 6 96.40 Very High Very High Very High
adenocard 38 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 319 99.84 Very High Very High Very High
Inflammatory Bowel Disease 10 99.82 Very High Very High Very High
Targeted Disruption 41 99.28 Very High Very High Very High
Cancer 113 99.22 Very High Very High Very High
Inflammatory Breast Neoplasms 34 99.10 Very High Very High Very High
Alzheimer's Dementia 1 98.88 Very High Very High Very High
Injury 115 98.56 Very High Very High Very High
Disease 174 98.46 Very High Very High Very High
Sensorineural Hearing Loss 140 98.28 Very High Very High Very High
INFLAMMATION 165 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the healing-promoting effect is associated with the stimulation of angiogenesis via an increase in VEGF expression (EP4).
Gene_expression (expression) of EP4
1) Confidence 0.67 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.27 Pain Relevance 0.20
Among various prostanoids affected by NSAIDs, prostaglandin E2 (PGE2), in particular, seems to play critical roles in IBD via the EP4 receptor, one of the four PGE2 receptor subtypes (EP1-4).
Gene_expression (one) of EP4 in PGE2 associated with inflammatory bowel disease and cinod
2) Confidence 0.67 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17008451 Disease Relevance 0.65 Pain Relevance 0.49
Similar expression patterns of EP3 and EP4 in the Day 4 pseudopregnant mouse uterus or in the ovariectomized uterus under combined treatment with estrogen and progesterone suggest that these genes are regulated by ovarian steroids rather than by the embryo during the preimplantation period (Days 1-4).
Gene_expression (expression) of EP4 in uterus
3) Confidence 0.66 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.24 Pain Relevance 0.08
In contrast, expression of EP3 in a subpopulation of cells in the stromal bed at the mesometrial side, and of EP4 in the epithelium and stroma on these days, suggests that PGE2 effects on uterine preparation for implantation (such as epithelial cell differentiation, stromal cell proliferation, uterine edema, luminal closure, and increased localized endometrial vascular permeability at the sites of blastocyst attachment) are mediated by these receptor subtypes.
Spec (suggests) Gene_expression (expression) of EP4 in uterine associated with pressure and volume under development
4) Confidence 0.66 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.27 Pain Relevance 0.10
Tumor growth, with and without provision of a classical cyclo-oxygenase inhibitor (indomethacin), was related to tumor content of COX-1/COX-2 protein as well as to EP1-EP4 and prostacyclin receptor expression.
Gene_expression (expression) of EP4 associated with cancer
5) Confidence 0.65 Published 2005 Journal Int. J. Oncol. Section Abstract Doc Link 16142306 Disease Relevance 1.19 Pain Relevance 0.34
Based on these findings, we previously examined the expression of EP4 in the cochlea, and the potential of an EP4 agonist to protect the cochlea against noise-induced trauma [9].
Spec (examined) Gene_expression (expression) of EP4 in cochlea associated with injury and agonist
6) Confidence 0.61 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.64 Pain Relevance 0.23
We initially confirmed that EP2 expression occurred in the cochlea and showed a similar pattern to EP4 expression [9].
Gene_expression (expression) of EP4 in cochlea
7) Confidence 0.61 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.26 Pain Relevance 0.23
Our results demonstrated both EP4 expression in the cochlea, and cochlear protection against noise trauma as a result of the local application of an EP4 agonist.
Gene_expression (expression) of EP4 in cochlear associated with injury and agonist
8) Confidence 0.61 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.58 Pain Relevance 0.24
The underlying mechanisms of these actions of PGE2 in the stomach, duodenum, or small intestine are related to inhibition of stomach contraction (EP1), stimulation of duodenal HCO3- secretion (EP3/EP4), or suppression of bacterial invasion due to inhibition of intestinal contraction (EP4) and stimulation of mucus secretion (EP3/EP4) respectively, although the mechanisms related to the esophageal protection remain unknown.
Gene_expression (/) of EP4 in duodenum
9) Confidence 0.58 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.37 Pain Relevance 0.34
PGE2 receptors are classified into four subtypes, EP1, EP2, EP3, and EP4.
Gene_expression (classified) of EP4
10) Confidence 0.58 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.05 Pain Relevance 0
The other EP2-positive and EP4-positive regions of the cochlea, including the supporting cells, hair cells, spiral ligament, and stria vascularis, showed little or no immunoreactivity for VEGF under all of the experimental conditions, and no changes in VEGF immunoreactivity were observed.
Gene_expression (positive) of EP4 in stria vascularis
11) Confidence 0.53 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.35 Pain Relevance 0.22
VEGF increase due to EP2 and EP4 agonists
Gene_expression (agonists) of EP4 associated with agonist
12) Confidence 0.53 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.15 Pain Relevance 0.22
Local application of EP2 or EP4 agonist to inner ears
Gene_expression (agonist) of EP4 in inner ears associated with agonist
13) Confidence 0.53 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0 Pain Relevance 0.29
Similar expression patterns of EP3 and EP4 in the Day 4 pseudopregnant mouse uterus or in the ovariectomized uterus under combined treatment with estrogen and progesterone suggest that these genes are regulated by ovarian steroids rather than by the embryo during the preimplantation period (Days 1-4).
Gene_expression (patterns) of EP4 in uterus
14) Confidence 0.51 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.23 Pain Relevance 0.08
EP4 was also detected in mouse oocytes and was located primarily near the oocyte nucleus (Figure 2I).
Gene_expression (detected) of EP4 in oocytes
15) Confidence 0.51 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.06
In vivo, cumulus cells surrounding oocytes also express EP2 and EP4 receptors, and cAMP generated within cumulus cells can move to the adjacent oocyte through junctional complexes connecting these cells.
Gene_expression (express) of EP4 in cumulus cells
16) Confidence 0.51 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Cumulus granulosa cells showed EP4 immunofluorescence (Figure 2G), consistent with reports of EP4 expression by cumulus cells [10] and serving as a positive control.
Gene_expression (expression) of EP4 in granulosa cells
17) Confidence 0.51 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.03
The present study confirmed that monkey and mouse cumulus granulosa cells expressed EP2 and EP4 receptor proteins.
Gene_expression (expressed) of EP4 receptor in granulosa cells
18) Confidence 0.51 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Interestingly, all mouse oocytes expressed EP2 and EP4 proteins, though EP2 mRNA was only detectable in 1 of 3 oocyte samples.
Gene_expression (expressed) of EP4 in oocyte
19) Confidence 0.51 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0.04
While the present study shows that EP2 and EP4 receptor proteins are expressed by mouse cumulus, further studies will be needed to confirm expression of EP3 receptor proteins.
Gene_expression (expressed) of EP4 receptor
20) Confidence 0.51 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0

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