INT68961

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 6.91
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger2) plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
inner ear 4
dendritic cells 3
PGE1 2
macrophage 2
microglia 2
Ptger2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 173 99.32 Very High Very High Very High
long-term potentiation 29 97.92 Very High Very High Very High
cytokine 33 97.72 Very High Very High Very High
chemokine 4 97.16 Very High Very High Very High
Inflammation 132 96.72 Very High Very High Very High
adenocard 11 93.68 High High
endometriosis 2 89.48 High High
Dismenorea 4 88.88 High High
cINOD 43 88.48 High High
COX-2 inhibitor 42 80.16 Quite High
Disease Link Frequency Relevance Heat
Cancer 171 100.00 Very High Very High Very High
Ganglion Cysts 51 99.04 Very High Very High Very High
Breast Cancer 93 97.92 Very High Very High Very High
Sensorineural Hearing Loss 30 97.68 Very High Very High Very High
Toxicity 5 97.00 Very High Very High Very High
INFLAMMATION 153 96.72 Very High Very High Very High
Drug Induced Neurotoxicity 3 95.76 Very High Very High Very High
Endometriosis (extended) 13 93.92 High High
Apoptosis 175 93.52 High High
Targeted Disruption 53 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While EP1 is coupled to Ca2+ mobilization, activation of EP2 and EP4 triggers stimulation of adenylyl cyclase.
Positive_regulation (stimulation) of Positive_regulation (activation) of EP2
1) Confidence 0.44 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.06 Pain Relevance 0
By contrast, the activation of EP3 decreases cAMP levels, which suggests that the selective activation of EP2 and/or EP4 might increase the clinical efficacy of PGE1 for the treatment of acute SNHL.
Spec (might) Positive_regulation (increase) of Positive_regulation (activation) of EP2 in PGE1 associated with sensorineural hearing loss
2) Confidence 0.41 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.66 Pain Relevance 0.23
Immunostaining for VEGF showed that the strongest response to EP2 or EP4 stimulation occurred in the spiral ganglion neurons, suggesting that they are responsible for increasing the VEGF levels in the inner ear.
Positive_regulation (response) of Positive_regulation (stimulation) of EP2 in inner ear associated with ganglion cysts
3) Confidence 0.41 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.24 Pain Relevance 0.18
ELISA and real-time qRT-PCR analyses demonstrated an increase of VEGF protein and mRNA levels in the inner ear after local EP2 or EP4 agonist application, indicating that the stimulation of EP2 and/or EP4 activates VEGF production in the inner ear.
Positive_regulation (activates) of Positive_regulation (stimulation) of EP2 in inner ear associated with agonist
4) Confidence 0.41 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.23 Pain Relevance 0.19
The TBS that induces LTP causes bidirectional trafficking of EP2 and EP3 into the membrane and the cytosol, respectively, which results in an increase in EP2 and a decrease in EP3 at the membrane.
Positive_regulation (results) of Positive_regulation (increase) of EP2 associated with long-term potentiation
5) Confidence 0.30 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0 Pain Relevance 0.40
This study demonstrates that co-activation of the EP2 and FP receptors results in enhanced release of cAMP, in a G?
Positive_regulation (results) of Positive_regulation (activation) of EP2
6) Confidence 0.28 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.61 Pain Relevance 0
We have shown activation of the EP2 and FP receptors can lead to phosphorylation of ERK1/2 via the activation of c-Src and transphosphorylation of the epidermal growth factor receptor (EGFR) in Ishikawa cells and endometrial adenocarcinoma explants ex vivo [7,18].
Positive_regulation (lead) of Positive_regulation (activation) of EP2 associated with endometriosis (extended)
7) Confidence 0.28 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0.45 Pain Relevance 0.13
716 mice, thus indicating that the induction of the COX-2/PGE2 pathway and subsequent macrophage infiltration are not sufficient for the promotion of Wnt/?
Neg (not) Positive_regulation (sufficient) of Positive_regulation (induction) of PGE2 in macrophage
8) Confidence 0.05 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.21 Pain Relevance 0
Activation of microglia EP2 receptor with PGE2 increased A?
Positive_regulation (increased) of Positive_regulation (Activation) of microglia EP2 receptor in microglia
9) Confidence 0.03 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.97 Pain Relevance 0.17
Our study conducted in newly diagnosed stage I and stage II breast cancer patients [9] showed impaired functionality of T cells and dendritic cells, which correlated with COX-2 overexpression in the tumors and increased levels of PGE2 in the serum and tumor milieu.
Positive_regulation (overexpression) of Positive_regulation (increased) of PGE2 in dendritic cells associated with cancer and breast cancer
10) Confidence 0.03 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 1.15 Pain Relevance 0.56
B leads directly to high levels of COX-2, PGE2, the gap junction protein connexin 43, and upregulation of the oxytocin receptor [20].
Positive_regulation (leads) of Positive_regulation (upregulation) of PGE2
11) Confidence 0.03 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2933901 Disease Relevance 0.58 Pain Relevance 0.48
These findings are consistent with others showing that celecoxib enhances caspase-3 or caspase-9 activation through PGE2 inhibition [42,43].
Positive_regulation (enhances) of Positive_regulation (activation) of PGE2
12) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.60 Pain Relevance 0.11
Our study conducted in newly diagnosed stage I and stage II breast cancer patients [9] showed impaired functionality of T cells and dendritic cells, which correlated with COX-2 overexpression in the tumors and increased levels of PGE2 in the serum and tumor milieu.
Positive_regulation (overexpression) of in T cells Positive_regulation (increased) of PGE2 in dendritic cells associated with cancer and breast cancer
13) Confidence 0.01 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 1.15 Pain Relevance 0.56

General Comments

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