INT68962

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 7.30
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger4) plasma membrane (Ptger4) signal transducer activity (Ptger4)
Anatomy Link Frequency
inner ear 3
oocyte 2
neuronal 1
PGE1 1
neuron 1
Ptger4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 467 99.96 Very High Very High Very High
antagonist 70 98.40 Very High Very High Very High
adenocard 17 93.68 High High
Central nervous system 20 91.32 High High
qutenza 2 83.28 Quite High
midbrain 2 82.92 Quite High
Thalamus 2 82.52 Quite High
Hippocampus 8 82.12 Quite High
cerebral cortex 2 81.60 Quite High
Intracerebroventricular 1 80.00 Quite High
Disease Link Frequency Relevance Heat
Death 155 99.66 Very High Very High Very High
Ganglion Cysts 136 99.42 Very High Very High Very High
Peptic Ulcer 6 99.22 Very High Very High Very High
Cancer 27 98.96 Very High Very High Very High
Inflammatory Breast Neoplasms 34 98.84 Very High Very High Very High
Mycobacterial Infection 288 98.16 Very High Very High Very High
Apoptosis 116 97.88 Very High Very High Very High
Sensorineural Hearing Loss 80 97.08 Very High Very High Very High
Necrosis 165 95.44 Very High Very High Very High
Metastasis 3 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results confirmed the importance of COX-2/PGE2 in the healing mechanism of gastric ulcers and further suggested that the healing-promoting action of PGE2 is mediated by the activation of EP4 receptors and is associated with VEGF expression.
Positive_regulation (activation) of EP4 associated with peptic ulcer
1) Confidence 0.67 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17673547 Disease Relevance 0.36 Pain Relevance 0.21
While EP1 is coupled to Ca2+ mobilization, activation of EP2 and EP4 triggers stimulation of adenylyl cyclase.
Positive_regulation (activation) of EP4
2) Confidence 0.59 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.06 Pain Relevance 0
ELISA and real-time qRT-PCR analyses demonstrated an increase of VEGF protein and mRNA levels in the inner ear after local EP2 or EP4 agonist application, indicating that the stimulation of EP2 and/or EP4 activates VEGF production in the inner ear.
Positive_regulation (stimulation) of EP4 in inner ear associated with agonist
3) Confidence 0.55 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.23 Pain Relevance 0.19
For mechanisms of VEGF induction via EP2 or EP4 activation, recent studies have indicated involvement of cAMP- and PKA-dependent mechanisms via SP-1 transcription factor binding sites on the VEGF promoter [12,24,25].
Positive_regulation (activation) of EP4
4) Confidence 0.55 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.17 Pain Relevance 0.06
PGE2 also shows a healing-promoting effect on gastric ulcers as well as intestinal lesions via the activation of EP4 receptors.
Positive_regulation (activation) of EP4 associated with peptic ulcer
5) Confidence 0.40 Published 2010 Journal Adv Clin Chem Section Abstract Doc Link 20857620 Disease Relevance 0.41 Pain Relevance 0.39
Immunostaining for VEGF showed that the strongest response to EP2 or EP4 stimulation occurred in the spiral ganglion neurons, suggesting that they are responsible for increasing the VEGF levels in the inner ear.
Positive_regulation (stimulation) of EP4 in inner ear associated with ganglion cysts
6) Confidence 0.40 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.24 Pain Relevance 0.18
The present results demonstrated spiral ganglion neuron responses to EP2 and EP4 stimulation, and the expression of both Flt-1 and Flk-1 in various cochlear components including the sensory epithelium, spiral ganglion, and stria vascularis.
Positive_regulation (stimulation) of EP4 in neuron associated with ganglion cysts
7) Confidence 0.40 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.37 Pain Relevance 0.07
In the present study, we highlighted VEGF induction via EP2 or EP4 activation.
Positive_regulation (activation) of EP4
8) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.31 Pain Relevance 0.24
By contrast, the activation of EP3 decreases cAMP levels, which suggests that the selective activation of EP2 and/or EP4 might increase the clinical efficacy of PGE1 for the treatment of acute SNHL.
Positive_regulation (activation) of EP4 in PGE1 associated with sensorineural hearing loss
9) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.65 Pain Relevance 0.23
VEGF increase due to EP2 and EP4 agonists
Positive_regulation (increase) of EP4 associated with agonist
10) Confidence 0.37 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.16 Pain Relevance 0.22
Stimulation of EP2 and EP4 receptors increased oocyte cAMP levels.
Positive_regulation (Stimulation) of EP4 in oocyte
11) Confidence 0.31 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
Stimulation of EP2 and EP4 receptors triggers activation of adenylate cyclase (48).
Positive_regulation (Stimulation) of EP4
12) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0 Pain Relevance 0
These results are consistent with a mechanism wherein EP2 activation of PKA, rather than EP4 activation of PI3K, mediates the protective effect of PGE2 on mitochondria of Mtb-infected M?.


Positive_regulation (activation) of EP4 associated with mycobacterial infection
13) Confidence 0.25 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.90 Pain Relevance 0
These results suggest that WPLPR decreases food intake through PGE2 production followed by EP4 receptor activation.
Positive_regulation (activation) of EP4 receptor
14) Confidence 0.21 Published 2007 Journal Peptides Section Abstract Doc Link 17207895 Disease Relevance 0 Pain Relevance 0.23
Although PGE2 stimulation of the EP4 receptor triggers activation of PI3K and of Akt (48), blockade of mitochondrial damage by PGE2 critical for prevention of necrosis is mediated through the EP2 receptor.
Positive_regulation (stimulation) of EP4 receptor associated with necrosis
15) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.19 Pain Relevance 0.13
The activation of EP1 elevates the levels of intracellular inositol phosphate and Ca2+ (Watabe et al. 1993), whereas the activation of EP2 or EP4 stimulates adenylate cyclase, resulting in increased levels of intracellular cAMP (Jumblatt and Paterson, 1991).
Positive_regulation (activation) of EP4
16) Confidence 0.18 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759147 Disease Relevance 0.11 Pain Relevance 0.27
However, further studies are needed to determine signaling cascades for VEGF induction via EP2 and EP4 in the inner ear.
Positive_regulation (induction) of EP4 in inner ear
17) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.20 Pain Relevance 0.03
In both monkey and mouse oocytes, stimulation of EP2 and EP4 receptors increased cAMP as anticipated.
Positive_regulation (stimulation) of EP4 in oocytes
18) Confidence 0.13 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2988801 Disease Relevance 0 Pain Relevance 0
IBC tumor cells with high Cox-2 expression also express high levels of EP4 receptor (Fig. 5C).
Positive_regulation (levels) of EP4 receptor associated with inflammatory breast neoplasms and cancer
19) Confidence 0.11 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 1.03 Pain Relevance 0.17
Activation of EP1 contributes to neuronal excitotoxic death, in contrast to activation of EP2 [51-53] and EP4 [50] which promote neuroprotection [see [49] for review].
Positive_regulation (activation) of EP4 in neuronal associated with death
20) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2873241 Disease Relevance 0.68 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox