INT68965

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.43
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptger4) plasma membrane (Ptger4) signal transducer activity (Ptger4)
Anatomy Link Frequency
inner ear 4
Ptger4 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 108 99.32 Very High Very High Very High
Dismenorea 1 33.52 Quite Low
COX2 16 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Versed 6 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
cOX1 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 34 99.04 Very High Very High Very High
Mycobacterial Infection 96 97.28 Very High Very High Very High
Infection 61 92.00 High High
Necrosis 54 91.40 High High
Apoptosis 34 79.44 Quite High
Death 20 74.80 Quite High
Sensorineural Hearing Loss 20 68.24 Quite High
Pressure And Volume Under Development 4 59.20 Quite High
Dysmenorrhea 1 33.52 Quite Low
Injury 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While EP1 is coupled to Ca2+ mobilization, activation of EP2 and EP4 triggers stimulation of adenylyl cyclase.
Positive_regulation (stimulation) of Positive_regulation (activation) of EP4
1) Confidence 0.43 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9116135 Disease Relevance 0.06 Pain Relevance 0
ELISA and real-time qRT-PCR analyses demonstrated an increase of VEGF protein and mRNA levels in the inner ear after local EP2 or EP4 agonist application, indicating that the stimulation of EP2 and/or EP4 activates VEGF production in the inner ear.
Positive_regulation (activates) of Positive_regulation (stimulation) of EP4 in inner ear associated with agonist
2) Confidence 0.40 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.23 Pain Relevance 0.19
Immunostaining for VEGF showed that the strongest response to EP2 or EP4 stimulation occurred in the spiral ganglion neurons, suggesting that they are responsible for increasing the VEGF levels in the inner ear.
Positive_regulation (response) of Positive_regulation (stimulation) of EP4 in inner ear associated with ganglion cysts
3) Confidence 0.40 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2847564 Disease Relevance 0.24 Pain Relevance 0.18
These results are consistent with a mechanism wherein EP2 activation of PKA, rather than EP4 activation of PI3K, mediates the protective effect of PGE2 on mitochondria of Mtb-infected M?.


Positive_regulation (activation) of Positive_regulation (activation) of EP4 associated with mycobacterial infection
4) Confidence 0.18 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 0.90 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox