INT68970

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 33
Total Number 33
Disease Relevance 9.29
Pain Relevance 19.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
spinal 3
GPI 2
cleavage 2
NS20Y 2
MVD 2
Pnoc (Mus musculus)
Pnoc - N27K (1) Pnoc - N23K (1)
Pain Link Frequency Relevance Heat
orphanin 196 100.00 Very High Very High Very High
Opioid 25 100.00 Very High Very High Very High
Potency 3 100.00 Very High Very High Very High
Antinociceptive 19 99.98 Very High Very High Very High
Hyperalgesia 14 99.96 Very High Very High Very High
Intracerebroventricular 4 99.80 Very High Very High Very High
Pain 38 99.76 Very High Very High Very High
tail-flick 8 99.76 Very High Very High Very High
amygdala 4 99.00 Very High Very High Very High
narcan 20 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 24 99.98 Very High Very High Very High
Pain 20 99.76 Very High Very High Very High
Nociception 32 99.68 Very High Very High Very High
Hypoxia 3 98.92 Very High Very High Very High
Diabetes Mellitus 14 98.84 Very High Very High Very High
Neuropathic Pain 6 98.20 Very High Very High Very High
INFLAMMATION 4 98.04 Very High Very High Very High
Anxiety Disorder 7 98.00 Very High Very High Very High
Stress 21 95.04 Very High Very High Very High
Bordatella Infection 2 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nociceptive effects of both peptides were not affected by 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazole-2-one (J-113397) (i.pl.), an N/OFQ receptor antagonist, indicating that they are mediated by a novel mechanism independent of activation of N/OFQ receptor.
Positive_regulation (activation) of N/OFQ associated with nociception and antagonist
1) Confidence 0.67 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12665541 Disease Relevance 0.65 Pain Relevance 0.76
Nociceptin/orphanin FQ (N/OFQ) modulates various biological functions, including nociception, via selective stimulation of the N/OFQ peptide receptor (NOP).
Positive_regulation (stimulation) of N/OFQ associated with nociception and orphanin
2) Confidence 0.67 Published 2007 Journal Peptides Section Abstract Doc Link 17161885 Disease Relevance 0.10 Pain Relevance 0.59
Collectively, these results demonstrate that endogenous N/OFQ-NOP receptor signalling is activated during the mouse formalin test producing spinal antinociceptive and supraspinal pronociceptive effects.
Positive_regulation (activated) of N/OFQ in spinal associated with antinociceptive
3) Confidence 0.67 Published 2006 Journal Pain Section Abstract Doc Link 16697109 Disease Relevance 0.49 Pain Relevance 0.33
Initial results on a combined region of the brain containing various limbic components, revealed increased levels of pNOC mRNA in response to SEA challenge, but not to LPS.
Positive_regulation (increased) of pNOC mRNA in brain
4) Confidence 0.67 Published 2002 Journal Brain Res. Section Abstract Doc Link 12213301 Disease Relevance 0.51 Pain Relevance 0.44
Further analysis of more discrete brain regions revealed increased pNOC mRNA in the hypothalamus and amygdala in response to SEA.
Positive_regulation (increased) of pNOC mRNA in amygdala associated with amygdala
5) Confidence 0.67 Published 2002 Journal Brain Res. Section Abstract Doc Link 12213301 Disease Relevance 0.51 Pain Relevance 0.46
This work was designed to observe the effects of nociceptin(13-17), one of the main metabolites of nociceptin (also termed orphanin FQ), in pain modulation at supraspinal level in mice.
Positive_regulation (termed) of orphanin FQ associated with pain and orphanin
6) Confidence 0.50 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12361849 Disease Relevance 0.38 Pain Relevance 0.70
Antisera were generated against nociceptin/orphanin FQ, the putative ligand of the opioid receptor-like ORL1 receptor.
Positive_regulation (generated) of nociceptin associated with orphanin and opioid receptor
7) Confidence 0.49 Published 1996 Journal Neuroreport Section Abstract Doc Link 9116232 Disease Relevance 0.14 Pain Relevance 0.87
These results indicate that the inhibitory action of N/OFQ on excitatory glutamatergic synaptic transmission and its spinal antinociceptive action are mediated via the N/OFQ receptor, whereas the action of NST is independent of this receptor.
Positive_regulation (mediated) of N/OFQ in spinal associated with antinociceptive
8) Confidence 0.49 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11179457 Disease Relevance 0.17 Pain Relevance 0.53
The results of the present experiments clearly indicate that the antinociceptive potency of nociceptin/orphanin FQ is significantly greater in diabetic mice than in non-diabetic mice.
Positive_regulation (potency) of orphanin FQ associated with diabetes mellitus, orphanin, antinociceptive and potency
9) Confidence 0.49 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10323258 Disease Relevance 1.12 Pain Relevance 1.49
In vivo, J-113397, when administered subcutaneously (s.c.), dose-dependently inhibited hyperalgesia elicited by intracerebroventricular (i.c.v.) administration of nociceptin/orphanin FQ in a tail-flick test with mice.
Positive_regulation (administration) of orphanin FQ in tail associated with hyperalgesia, orphanin, tail-flick and intracerebroventricular
10) Confidence 0.49 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940356 Disease Relevance 0.10 Pain Relevance 0.72
The binding sites of [3H]nociceptin (also named Orphanin FQ), the endogenous ligand of the ORL1 (opiate receptor like 1) receptor, were localized in the central nervous system of the mouse using an autoradiographic procedure.
Positive_regulation (named) of Orphanin FQ in central nervous system associated with orphanin, central nervous system and opiate
11) Confidence 0.48 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9259457 Disease Relevance 0.06 Pain Relevance 0.56
Low affinity for the classical opioid receptors together with the inability of naloxone to antagonize its effect suggest that the inhibitory action of OFQ is mediated via a distinct OFQ receptor in the GPI and MVD.
Positive_regulation (mediated) of OFQ in MVD associated with narcan and opioid receptor
12) Confidence 0.48 Published 1997 Journal Brain Res. Section Abstract Doc Link 9406961 Disease Relevance 0 Pain Relevance 0.52
We recently discovered N23K and its splicing variant N27K as transcripts upregulated in mouse NS20Y cells after differentiation induced by dibutylyl cyclic AMP (dbcAMP) treatment.
Positive_regulation (upregulated) of N23K (N23K) in NS20Y
13) Confidence 0.47 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.33
The antianalgesic action of nociceptin is mediated by spinal PGE2 and attenuated by i.t.
Positive_regulation (action) of nociceptin in spinal associated with orphanin
14) Confidence 0.45 Published 2002 Journal Life Sci. Section Abstract Doc Link 11860156 Disease Relevance 0 Pain Relevance 0.51
Orphanin FQ/nociceptin (OFQ/N) is generated from a larger precursor peptide, prepro-orphanin FQ (ppOFQ).
Positive_regulation (generated) of prepro-orphanin FQ associated with orphanin
15) Confidence 0.44 Published 1998 Journal Neuroreport Section Abstract Doc Link 9601687 Disease Relevance 0 Pain Relevance 0.86
This work was designed to observe the effects of nociceptin(13-17), one of the main metabolites of nociceptin (also termed orphanin FQ), in pain modulation at supraspinal level in mice.
Positive_regulation (termed) of nociceptin associated with pain and orphanin
16) Confidence 0.44 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12361849 Disease Relevance 0.38 Pain Relevance 0.67
Tetrodotoxin and the nitric oxide (NO) synthase inhibitor Nomega-nitro-L-arginine also produced contractions which were quantitatively similar to those seen in response to nociceptin.
Positive_regulation (response) of nociceptin associated with tetrodotoxin and orphanin
17) Confidence 0.43 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10666511 Disease Relevance 0 Pain Relevance 0.58
We recently showed that intrathecal administration of nociceptin or orphanin FQ (hereafter called nociceptin) induced hyperalgesia to noxious thermal stimuli and allodynia to innocuous tactile stimuli applied to conscious mice.
Positive_regulation (induced) of nociceptin associated with hyperalgesia, allodynia, orphanin and intrathecal
18) Confidence 0.43 Published 2000 Journal Neuroscience Section Abstract Doc Link 10771345 Disease Relevance 0.68 Pain Relevance 1.36
Low affinity for the classical opioid receptors together with the inability of naloxone to antagonize its effect suggest that the inhibitory action of OFQ is mediated via a distinct OFQ receptor in the GPI and MVD.
Positive_regulation (action) of OFQ in MVD associated with narcan and opioid receptor
19) Confidence 0.42 Published 1997 Journal Brain Res. Section Abstract Doc Link 9406961 Disease Relevance 0 Pain Relevance 0.52
We recently discovered N23K and its splicing variant N27K as transcripts upregulated in mouse NS20Y cells after differentiation induced by dibutylyl cyclic AMP (dbcAMP) treatment.
Positive_regulation (upregulated) of N27K (N27K) in NS20Y
20) Confidence 0.41 Published 1997 Journal J. Neurosci. Res. Section Abstract Doc Link 9185664 Disease Relevance 0 Pain Relevance 0.33

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