INT68973

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Context Info
Confidence 0.52
First Reported 1996
Last Reported 2011
Negated 3
Speculated 0
Reported most in Abstract
Documents 89
Total Number 89
Disease Relevance 58.56
Pain Relevance 30.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
brain 6
lung 4
lateral 3
pituitary 3
ECM 3
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 1597 100.00 Very High Very High Very High
Inflammatory mediators 31 100.00 Very High Very High Very High
ischemia 469 99.98 Very High Very High Very High
depression 13 99.80 Very High Very High Very High
Neuritis 12 99.68 Very High Very High Very High
fibrosis 327 99.48 Very High Very High Very High
Central nervous system 54 99.28 Very High Very High Very High
Inflammation 660 99.26 Very High Very High Very High
Hippocampus 85 99.24 Very High Very High Very High
Eae 24 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 713 100.00 Very High Very High Very High
Cv Unclassified Under Development 328 99.98 Very High Very High Very High
Cv General 4 Under Development 101 99.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 198 99.96 Very High Very High Very High
Injury 345 99.88 Very High Very High Very High
Reperfusion Injury 506 99.84 Very High Very High Very High
Diabetes Mellitus 332 99.84 Very High Very High Very High
Cancer 152 99.84 Very High Very High Very High
Urological Neuroanatomy 24 99.80 Very High Very High Very High
Depression 13 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This peak in TNF-alpha protein expression corresponds to an increase in gelatinase B (MMP-9) activity, which is greatly upregulated as early as 3 h following CCI to rat sciatic nerve.
Positive_regulation (increase) of gelatinase B in sciatic nerve associated with eae and sciatic nerve
1) Confidence 0.52 Published 2000 Journal Brain Res. Section Abstract Doc Link 10650133 Disease Relevance 1.10 Pain Relevance 0.83
This peak in TNF-alpha protein expression corresponds to an increase in gelatinase B (MMP-9) activity, which is greatly upregulated as early as 3 h following CCI to rat sciatic nerve.
Positive_regulation (increase) of MMP-9 in sciatic nerve associated with eae and sciatic nerve
2) Confidence 0.52 Published 2000 Journal Brain Res. Section Abstract Doc Link 10650133 Disease Relevance 1.11 Pain Relevance 0.83
Our laboratory has focused on hippocampal mediated spatial memory and measured elevations in hippocampal MMP-3 and MMP-9 during acquisition of the Morris water
Positive_regulation (elevations) of MMP-9 associated with metalloproteinase
3) Confidence 0.50 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1838960 Disease Relevance 0.24 Pain Relevance 0.64
In the extract from the small intestine 24 h after indomethacin administration, the MMP-9 activation was significantly attenuated by TY-51469.
Positive_regulation (activation) of MMP-9 in small intestine associated with metalloproteinase
4) Confidence 0.46 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19996300 Disease Relevance 0.05 Pain Relevance 0.72
IL-1alpha significantly induced an increase of active MMP9 as well as pro- and active MMP3, but had no effect on the MMP2 activity in both types of cells.
Positive_regulation (increase) of MMP9
5) Confidence 0.46 Published 2001 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11330935 Disease Relevance 0.25 Pain Relevance 0.59
Quantitative polymerase chain reaction analysis revealed an up-regulation of MMP-9 mRNA with peak levels concurrent with maximal disease severity.
Positive_regulation (up-regulation) of MMP-9 associated with disease
6) Confidence 0.45 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9546322 Disease Relevance 1.06 Pain Relevance 0.64
Among the main differences between their molecular pathways, MMP-2 is constitutively expressed, while MMP-9 can be stimulated at the level of gene activation by multiple stimuli including ischemia.
Positive_regulation (activation) of MMP-9 associated with ischemia
7) Confidence 0.43 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.77 Pain Relevance 0.18
In ALI, and mainly in ARDS, increased levels of MMP-2 and MMP-9 in the bronchoalveolar lavage (BAL) have been suggested to play a role in basement membrane disruption [17].
Positive_regulation (increased) of MMP-9 in basement membrane associated with adult respiratory distress syndrome
8) Confidence 0.42 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 1.11 Pain Relevance 0.32
It was expected that the active forms of MMP-2 and MMP-9 might have been increased in the early phase of pulmonary fibrosis when the total MMP-2 and MMP-9 activity reached the maximum.
Positive_regulation (increased) of MMP-9 associated with fibrosis, metalloproteinase and pulmonary fibrosis
9) Confidence 0.42 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.42 Pain Relevance 1.04
MMPs are not only involved in tumor invasion but can also be a sign of CNS vascular injury as indicated by an increase in plasma levels of MMP9 and MMP13 in stroke patients [94].
Positive_regulation (increase) of MMP9 in plasma associated with stroke, cancer, metalloproteinase, central nervous system and vasculitis
10) Confidence 0.41 Published 2008 Journal Radiat Oncol Section Body Doc Link PMC2556333 Disease Relevance 1.40 Pain Relevance 0.35
A beta (1-38) and A beta (1-40) were effective in stimulating MMP-9 activity in a dose-dependent fashion.
Positive_regulation (stimulating) of MMP-9
11) Confidence 0.41 Published 1996 Journal Neuroreport Section Abstract Doc Link 9116244 Disease Relevance 0.32 Pain Relevance 0.30
Until 6 h after oral administration of indomethacin in rats, intestinal MMP-9 activity was unchanged compared with normal rats, but significant increases in MMP-9 activity were observed 12 and 24 h after indomethacin administration.
Positive_regulation (increases) of MMP-9 associated with metalloproteinase
12) Confidence 0.40 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19996300 Disease Relevance 0.07 Pain Relevance 0.79
Until 6 h after oral administration of indomethacin in rats, intestinal MMP-9 activity was unchanged compared with normal rats, but significant increases in MMP-9 activity were observed 12 and 24 h after indomethacin administration.
Positive_regulation (increases) of MMP-9 associated with metalloproteinase
13) Confidence 0.40 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19996300 Disease Relevance 0.07 Pain Relevance 0.77
Until 6 h after oral administration of indomethacin in rats, intestinal MMP-9 activity was unchanged compared with normal rats, but significant increases in MMP-9 activity were observed 12 and 24 h after indomethacin administration.
Neg (unchanged) Positive_regulation (unchanged) of MMP-9 associated with metalloproteinase
14) Confidence 0.40 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19996300 Disease Relevance 0.07 Pain Relevance 0.78
This is consistent with an early rise of MMP-9 levels in the blood by 6-8 hours, followed by a reduction by 24 hours.
Positive_regulation (rise) of MMP-9 in blood
15) Confidence 0.39 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.62 Pain Relevance 0.06
Furthermore, increased MMP-9 activity was detected by zymography.
Positive_regulation (increased) of MMP-9
16) Confidence 0.39 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9546322 Disease Relevance 0.98 Pain Relevance 0.63
These findings indicate that 92-kd gelatinase and matrilysin are selectively up-regulated during EAN and expressed in nerves of GBS patients and thus may contribute to the pathogenesis of inflammatory demyelination of the peripheral nervous system.
Positive_regulation (up-regulated) of gelatinase in peripheral nervous system associated with demyelination, peripheral nervous system, inflammation, syndrome and neuritis
17) Confidence 0.39 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9546322 Disease Relevance 1.09 Pain Relevance 0.60
Studies showed that the activity of MMP-2 and MMP-9 is upregulated in many pulmonary diseases including pulmonary fibrosis,3-7 and they are secreted by many different kinds of cells in the lungs.8-11 But, the studies dealing with human lung can provide only a snap shot at a certain time point in its long course of disease.
Positive_regulation (upregulated) of MMP-9 in lung associated with fibrosis, pulmonary disease, metalloproteinase, pulmonary fibrosis and disease
18) Confidence 0.39 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.83 Pain Relevance 0.68
It was expected that the active forms of MMP-2 and MMP-9 might have been increased in the early phase of pulmonary fibrosis when the total MMP-2 and MMP-9 activity reached the maximum.
Positive_regulation (reached) of MMP-9 associated with fibrosis, metalloproteinase and pulmonary fibrosis
19) Confidence 0.39 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.40 Pain Relevance 1.01
MMP-2 and MMP-9 were markedly increased in both the BAL fluid and in the lung parenchyma of the bleomycin-treated rats, especially in the early phase with the peak on the 4th day.
Positive_regulation (increased) of MMP-9 in lung
20) Confidence 0.39 Published 2009 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2649867 Disease Relevance 0.49 Pain Relevance 0.48

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