INT68974

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.84
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
endothelial cells 1
sciatic nerve 1
brain 1
basement membrane 1
neutrophils 1
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 198 100.00 Very High Very High Very High
ischemia 41 99.98 Very High Very High Very High
Inflammation 54 99.46 Very High Very High Very High
Demyelination 2 98.84 Very High Very High Very High
dexamethasone 4 98.48 Very High Very High Very High
cINOD 1 96.24 Very High Very High Very High
Sciatic nerve 3 96.20 Very High Very High Very High
Neuritis 4 86.40 High High
cva 7 82.68 Quite High
Eae 1 81.80 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 27 99.98 Very High Very High Very High
Alzheimer's Dementia 2 99.72 Very High Very High Very High
INFLAMMATION 85 99.46 Very High Very High Very High
Fibrosarcoma 1 99.32 Very High Very High Very High
Demyelinating Disease 4 98.84 Very High Very High Very High
Stroke 105 98.74 Very High Very High Very High
Disease 11 94.36 High High
Injury 36 89.32 High High
Syndrome 6 88.80 High High
Neuropathic Pain 1 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
beta-Amyloid induction of gelatinase B secretion in cultured microglia: inhibition by dexamethasone and indomethacin.
Localization (secretion) of gelatinase B in microglia associated with alzheimer's dementia and dexamethasone
1) Confidence 0.80 Published 1996 Journal Neuroreport Section Title Doc Link 9116244 Disease Relevance 0.38 Pain Relevance 0.30
Upon degranulation, neutrophils release preformed granules containing proteolytic enzymes, including matrix metalloproteinase-9 (MMP-9), that facilitate migration of leukocytes across the BBB to ischemic brain tissue [18].
Localization (release) of MMP-9 in neutrophils associated with metalloproteinase
2) Confidence 0.63 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.65 Pain Relevance 0.13
Immunohistochemically, MMP-9 could be localized primarily around blood vessels within the epineurium and endoneurium in diseased but not normal sciatic nerve.
Localization (calized p) of MMP-9 in sciatic nerve associated with sciatic nerve
3) Confidence 0.63 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9546322 Disease Relevance 1.05 Pain Relevance 0.61
TNF co-localized with myelin degrading MMP-9 within Schwann cells during demyelination, and intraaxonally during remyelination.
Localization (co-localized) of MMP-9 in Schwann cells associated with demyelination and metalloproteinase
4) Confidence 0.54 Published 2002 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 11939349 Disease Relevance 0.85 Pain Relevance 0.77
Within hours after stroke onset, endothelial and inflammatory cells respond to ischemia releasing proteases MMP-2 and MMP-9 that culminate in degradation of the basal lamina and ultimate weakening of the blood brain barrier [23].
Localization (releasing) of MMP-9 in brain associated with inflammation, stroke and ischemia
5) Confidence 0.49 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.97 Pain Relevance 0.14
Homogenates were immunoblotted with occludin and claudin-5 (Zymed Laboratories, Carlsbad, CA), collagen IV (Abcam, Cambridge, MA), MMP-2, and MMP-9 (Calbiochem, Gibbstown, NJ) antibodies, respectively.
Localization (immunoblotted) of MMP-9 associated with metalloproteinase
6) Confidence 0.40 Published 2010 Journal Diabetes Section Body Doc Link PMC2797926 Disease Relevance 0.12 Pain Relevance 0.17
To confirm MMP-9 activity, aliquots of BAL fluid were analyzed by Western blotting with anti-human MMP-9 monoclonal antibody, which was raised against MMP-9 secreted by human HT1080 fibrosarcoma cells [27] and cross-reacts with rat MMP-9 [28].


Localization (secreted) of MMP-9 associated with fibrosarcoma and metalloproteinase
7) Confidence 0.28 Published 2004 Journal Respir Res Section Body Doc Link PMC538282 Disease Relevance 0.10 Pain Relevance 0.24
Since previous studies showed that these MMPs were co-localized with the type IV collagen in the basement membrane,3 the MMP-2 and MMP-9 in this early phase secreted by macrophages and neutrophils may play an important role in degrading the basement membrane, thereby facilitating the inflammatory cell migration.
Localization (secreted) of MMP-9 in basement membrane associated with inflammation and metalloproteinase
8) Confidence 0.27 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.39 Pain Relevance 0.81
, IL-6, sCD40L, IL-8, MMP-9, TIMP-1, IL-18, and adiponectin.
Localization (sCD40L) of MMP-9
9) Confidence 0.23 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.26 Pain Relevance 0.14
Preclinical studies have described that EPC secretion of factors involved in the regulation of stem cell recruitment and in vascular growth and remodeling (such as SDF-1, VEGF, HGF and MMP-9) [5], [17] support the function of mature endothelial cells in vitro and tissue regeneration in a variety of animal models [21], [22].
Localization (secretion) of MMP-9 in endothelial cells
10) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox