INT68975

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Context Info
Confidence 0.78
First Reported 1996
Last Reported 2011
Negated 1
Speculated 6
Reported most in Abstract
Documents 111
Total Number 117
Disease Relevance 79.57
Pain Relevance 38.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
extracellular matrix 7
endometrium 6
lung 5
tear 4
neutrophil 4
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 2865 100.00 Very High Very High Very High
Inflammation 1187 100.00 Very High Very High Very High
ischemia 359 100.00 Very High Very High Very High
Inflammatory mediators 93 100.00 Very High Very High Very High
Neuritis 21 100.00 Very High Very High Very High
Spinal cord 258 99.84 Very High Very High Very High
Sciatic nerve 19 99.84 Very High Very High Very High
Arthritis 68 99.76 Very High Very High Very High
Demyelination 33 99.76 Very High Very High Very High
Desipramine 1 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1312 100.00 Very High Very High Very High
Cancer 293 100.00 Very High Very High Very High
Apoptosis 79 100.00 Very High Very High Very High
Necrosis 64 100.00 Very High Very High Very High
Cv General 4 Under Development 43 100.00 Very High Very High Very High
Neuritis 12 100.00 Very High Very High Very High
Injury 441 99.96 Very High Very High Very High
Urological Neuroanatomy 81 99.92 Very High Very High Very High
Adult Respiratory Distress Syndrome 217 99.90 Very High Very High Very High
Glioma 25 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study examined the effects of chondroitin sulfate (CS) alone and CS plus glucosamine sulfate (GS) in a dietary bar formulation on inflammatory parameters of adjuvant-induced arthritis and on the synthesis of interleukin-1beta (IL-1beta) and matrix metalloprotease-9 (MMP-9).
Gene_expression (synthesis) of MMP-9 in bar associated with inflammation and arthritis
1) Confidence 0.78 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 15792947 Disease Relevance 0.63 Pain Relevance 0.24
Parameters of disease examined included clinical score (combination of joint temperature, edema, hyperalgesia, and standing and walking limb function), incidence of disease, levels of IL-1beta in the serum and paw joints, levels of MMP-9 in the paw joints, paw joint histology, and joint cartilage thickness.
Gene_expression (levels) of MMP-9 in paw joint associated with pressure and volume under development, hyperalgesia and disease
2) Confidence 0.78 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 15792947 Disease Relevance 1.04 Pain Relevance 0.34
The reduction of arthritic disease by CS plus GS is associated with a reduction of IL-1beta and MMP-9 synthesis.
Gene_expression (synthesis) of MMP-9 associated with disease and arthritis
3) Confidence 0.78 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 15792947 Disease Relevance 1.09 Pain Relevance 0.31
The present study investigated the expression of 92-kd gelatinase (MMP-9) and five other MMPs in sciatic nerve from Lewis rats with autoimmune experimental neuritis (EAN), an experimental model of the Guillain-Barré syndrome (GBS).
Spec (investigated) Gene_expression (xpression ) of MMP-9 in sciatic nerve associated with syndrome, metalloproteinase, sciatic nerve and neuritis
4) Confidence 0.70 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9546322 Disease Relevance 0.90 Pain Relevance 0.65
Matrix metalloproteinases MMP-9 and MMP-7 are expressed in experimental autoimmune neuritis and the Guillain-Barré syndrome.
Gene_expression (expressed) of MMP-9 associated with syndrome, experimental autoimmune neuritis, metalloproteinase and neuritis
5) Confidence 0.70 Published 1998 Journal Ann. Neurol. Section Title Doc Link 9546322 Disease Relevance 1.05 Pain Relevance 0.66
The present study investigated the expression of 92-kd gelatinase (MMP-9) and five other MMPs in sciatic nerve from Lewis rats with autoimmune experimental neuritis (EAN), an experimental model of the Guillain-Barré syndrome (GBS).
Spec (investigated) Gene_expression (xpression ) of gelatinase in sciatic nerve associated with syndrome, metalloproteinase, sciatic nerve and neuritis
6) Confidence 0.70 Published 1998 Journal Ann. Neurol. Section Abstract Doc Link 9546322 Disease Relevance 0.90 Pain Relevance 0.65
In saline-instilled control groups, MMP-2 and MMP-9 were expressed in moderate degrees in the bronchiolar epithelial cells and smooth muscle cells in the arteriolar wall, and weakly expressed in a few alveolar macrophages and type II pneumocytes as well as in some lymphocytes around the arterioles and bronchioles.
Gene_expression (expressed) of MMP-9 in epithelial cells associated with metalloproteinase
7) Confidence 0.64 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.66 Pain Relevance 0.31
Especially, those with the features of cellular injury, such as cellular swelling, vacuolization, and nuclear atypia, expressed MMP-2 and MMP-9 more prominently.
Gene_expression (expressed) of MMP-9 associated with injury, metalloproteinase and edema
8) Confidence 0.64 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.66 Pain Relevance 0.88
Bronchiolization, frequently observed from 4th to 7th day, is regarded as a reparative reaction to cellular injury to the alveolar epithelial cells.15,26 Also, cells surrounding the fibrotic foci are known to be derived from regenerating pneumocytes.27 The fact that the MMP-2 and MMP-9 were expressed in the cells with features of cellular injury/repair may suggest the roles of MMP-2 and MMP-9 in cellular regeneration.
Gene_expression (expressed) of MMP-9 in epithelial cells associated with fibrosis, injury and metalloproteinase
9) Confidence 0.64 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 1.07 Pain Relevance 0.86
After the 14th day when fibrosis progressed, the overall expression of the MMP-2 and MMP-9 was very low.
Gene_expression (expression) of MMP-9 associated with fibrosis and metalloproteinase
10) Confidence 0.64 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.94 Pain Relevance 0.86
This is maybe due to that in early phase, the MMP-9 was expressed strongly in neutrophils which more frequently existed in the intraalveolar spaces rather than in the lung parenchyma per se.
Gene_expression (expressed) of MMP-9 in lung associated with metalloproteinase
11) Confidence 0.64 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.25 Pain Relevance 0.80
The overall expression of MMP-2 and MMP-9 along the time sequence dynamically changed according to the immunohistochemical score.
Gene_expression (expression) of MMP-9 associated with metalloproteinase
12) Confidence 0.64 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.48 Pain Relevance 0.70
The influence of distinct classes of antidepressants, namely, electroconvulsive seizure, fluoxetine, tranylcypromine, and desipramine, on the gene expression of MMP-2, MMP-9, and TIMPs 1-4 in the hippocampus was determined using radioactive in situ hybridization.
Gene_expression (expression) of MMP-9 in hippocampus associated with desipramine, antidepressant, convulsion, hippocampus and fluoxetine
13) Confidence 0.62 Published 2008 Journal Synapse Section Abstract Doc Link 18509851 Disease Relevance 0.17 Pain Relevance 0.75
The results indicate that MMP9 and MMP3 were predominantly produced by disc cells, and these may be considered to play a pivotal role in ECM degradation during pathological conditions of the TMJ, such as IL-1-induced TMJ arthritis.
Gene_expression (produced) of MMP9 in TMJ associated with snapping jaw and arthritis
14) Confidence 0.59 Published 2001 Journal Eur. J. Oral Sci. Section Abstract Doc Link 11330935 Disease Relevance 0.49 Pain Relevance 0.63
Further study is required to better delineate MMP-9 mRNA expression patterns in blood, including the relationship with vascular reperfusion, duration of cerebral ischemia, treatment with tPA, and correlation with expression patterns of MMP-9 in cerebral tissue.


Gene_expression (expression) of MMP-9 in blood associated with cv general 4 under development and ischemia
15) Confidence 0.57 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.04 Pain Relevance 0.19
This is in contrast to the pattern of MMP-9 expression in the brain, where levels remain elevated at the 24-30 hour time point [27,28].
Gene_expression (expression) of MMP-9 in brain
16) Confidence 0.57 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.57 Pain Relevance 0.07
Cyclooxygenase inhibition resulted in exacerbation of IL-1 beta-mediated collagenase B (MMP-9) production and activity, as well as attenuation of type IV procollagen synthesis levels by endothelial cells in vitro.
Gene_expression (production) of MMP-9 in endothelial cells
17) Confidence 0.56 Published 2000 Journal Am J Orthod Dentofacial Orthop Section Abstract Doc Link 10935962 Disease Relevance 0.25 Pain Relevance 0.36
Although there was no statistically significant difference in the expression between the MMP-2 and MMP-9, MMP-2 appeared to be expressed at a higher level on the 4th day, compared to MMP-9 and also showed a tendency to decline less rapidly (Fig. 5).


Gene_expression (expressed) of MMP-9 associated with metalloproteinase
18) Confidence 0.56 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.27 Pain Relevance 0.65
Stroke index score, infarct volume, cerebral specific gravity, and the endogenous expression of tumor necrosis factor-alpha, matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in the brain tissue were quantified in the ischemic and matched contralateral nonischemic hemisphere.
Gene_expression (expression) of MMP-9 in brain associated with necrosis, cancer, stroke and metalloproteinase
19) Confidence 0.55 Published 2005 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15729288 Disease Relevance 1.63 Pain Relevance 0.55
The results indicate that cisplatin affects the expression of several genes associated with apoptosis (Cdkn1a, Ckap2, Bid3, S100a8, S100a9), inflammation (S100a8, S100a9, Cd163, Mmp9), and nerve growth and regeneration (Mmp9, Gfap, Fabp7).
Gene_expression (expression) of Mmp9 in nerve associated with inflammation and apoptosis
20) Confidence 0.53 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18191839 Disease Relevance 0.46 Pain Relevance 0.11

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