INT68976

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Context Info
Confidence 0.42
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 34
Total Number 39
Disease Relevance 28.21
Pain Relevance 11.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) aging (Mmp9)
extracellular region (Mmp9) proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9)
Anatomy Link Frequency
extracellular matrix 8
lung 8
plasma 4
spinal cords 4
microglia 4
Mmp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 890 100.00 Very High Very High Very High
Inflammatory mediators 64 100.00 Very High Very High Very High
Spinal cord 211 99.84 Very High Very High Very High
dexamethasone 8 99.80 Very High Very High Very High
Catecholamine 4 99.64 Very High Very High Very High
Central nervous system 92 99.28 Very High Very High Very High
depression 14 98.56 Very High Very High Very High
Inflammation 477 98.52 Very High Very High Very High
endometriosis 69 97.40 Very High Very High Very High
Nerve growth factor 30 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 553 100.00 Very High Very High Very High
Stress 626 99.98 Very High Very High Very High
Adult Respiratory Distress Syndrome 144 99.96 Very High Very High Very High
Urological Neuroanatomy 70 99.92 Very High Very High Very High
Multiple Sclerosis 925 99.68 Very High Very High Very High
Primary Sclerosing Cholangitis 6 99.60 Very High Very High Very High
Vasculitis 2 99.60 Very High Very High Very High
Stroke 31 99.44 Very High Very High Very High
Cancer 101 99.16 Very High Very High Very High
Arthropathy 42 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The overall expression of MMP-2 and MMP-9 along the time sequence dynamically changed according to the immunohistochemical score.
Positive_regulation (changed) of Gene_expression (expression) of MMP-9 associated with metalloproteinase
1) Confidence 0.42 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.48 Pain Relevance 0.70
Although there was no statistically significant difference in the expression between the MMP-2 and MMP-9, MMP-2 appeared to be expressed at a higher level on the 4th day, compared to MMP-9 and also showed a tendency to decline less rapidly (Fig. 5).


Positive_regulation (level) of Gene_expression (expressed) of MMP-9 associated with metalloproteinase
2) Confidence 0.42 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2649867 Disease Relevance 0.27 Pain Relevance 0.65
Co-treatment with INDO (50 microM) or DEX (100 nM) resulted in a 54% and 66% inhibition, respectively, of A beta (1-40)-stimulated MMP-9 production in microglia.
Positive_regulation (stimulated) of Gene_expression (production) of MMP-9 in microglia associated with dexamethasone
3) Confidence 0.41 Published 1996 Journal Neuroreport Section Abstract Doc Link 9116244 Disease Relevance 0.29 Pain Relevance 0.29
Co-treatment with INDO (50 microM) or DEX (100 nM) resulted in a 54% and 66% inhibition, respectively, of A beta (1-40)-stimulated MMP-9 production in microglia.
Positive_regulation (resulted) of Gene_expression (production) of MMP-9 in microglia associated with dexamethasone
4) Confidence 0.41 Published 1996 Journal Neuroreport Section Abstract Doc Link 9116244 Disease Relevance 0.30 Pain Relevance 0.30
Cyclooxygenase inhibition resulted in exacerbation of IL-1 beta-mediated collagenase B (MMP-9) production and activity, as well as attenuation of type IV procollagen synthesis levels by endothelial cells in vitro.
Positive_regulation (exacerbation) of Gene_expression (production) of MMP-9 in endothelial cells
5) Confidence 0.36 Published 2000 Journal Am J Orthod Dentofacial Orthop Section Abstract Doc Link 10935962 Disease Relevance 0.26 Pain Relevance 0.36
In ALI, and mainly in ARDS, increased levels of MMP-2 and MMP-9 in the bronchoalveolar lavage (BAL) have been suggested to play a role in basement membrane disruption [17].
Positive_regulation (increased) of Gene_expression (levels) of MMP-9 in basement membrane associated with adult respiratory distress syndrome
6) Confidence 0.28 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 1.11 Pain Relevance 0.32
MMPs are not only involved in tumor invasion but can also be a sign of CNS vascular injury as indicated by an increase in plasma levels of MMP9 and MMP13 in stroke patients [94].
Positive_regulation (increase) of Gene_expression (levels) of MMP9 in plasma associated with stroke, cancer, metalloproteinase, central nervous system and vasculitis
7) Confidence 0.28 Published 2008 Journal Radiat Oncol Section Body Doc Link PMC2556333 Disease Relevance 1.40 Pain Relevance 0.35
However, a combination of the catecholamine with LPS further enhances the increased production of MMP-1 and MMP-9.
Positive_regulation (enhances) of Gene_expression (production) of MMP-9 associated with catecholamine and metalloproteinase
8) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0.29
However, a combination of the catecholamine with LPS further enhances the increased production of MMP-1 and MMP-9.
Positive_regulation (increased) of Gene_expression (production) of MMP-9 associated with catecholamine and metalloproteinase
9) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819253 Disease Relevance 0 Pain Relevance 0.29
Two studies identified elevated MMP-9 levels in the lungs of newborns with acute respiratory distress syndrome [46,47].
Positive_regulation (elevated) of Gene_expression (levels) of MMP-9 in respiratory associated with adult respiratory distress syndrome
10) Confidence 0.25 Published 2010 Journal Proteome Sci Section Body Doc Link PMC2824689 Disease Relevance 0.32 Pain Relevance 0
No significant effect was obtained by pretreatment with GHRH, on the increased expression of gelatinase B due to ET injection.
Positive_regulation (increased) of Gene_expression (expression) of gelatinase B
11) Confidence 0.23 Published 2004 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 15276687 Disease Relevance 0.86 Pain Relevance 0.99
Western blot studies showed that animals stressed for 21 days after inoculation with MOG showed lower MMP-9 expression in spinal cord than animals only inoculated with MOG (figure 2A; F: 2,332, dF: 13).
Positive_regulation (lower) of Gene_expression (expression) of MMP-9 in spinal cord associated with spinal cord
12) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.05 Pain Relevance 0.13
In addition to increased levels of proinflammatory PGE2 that could modulate Th cell activity, the data obtained here suggest that subchronic stress could disrupt BBB integrity by enhancing MMP-9 expression (MMPs can influence expansion of the extracellular matrix of the BBB and loosening of intercellular tight junctions between endothelial cells through proteolytic degradation) and, as an increase in BBB permeability occurs prior to observable cellular infiltration in EAE [52], this may lead to an earlier appearance of clinical signs in stressed and inoculated animals.
Positive_regulation (enhancing) of Gene_expression (expression) of MMP-9 in endothelial cells associated with stress and multiple sclerosis
13) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.87 Pain Relevance 0.27
Conversely, chronically stressed (21 days) EAE-induced DA rats show increased 15d-PGJ2 levels, amelioration of clinical score, and reduced myelin loss, MMP-9 expression, MPO activity, and accumulation of neuroinflammatory mediators in the spinal cords of these animals.
Positive_regulation (increased) of Gene_expression (expression) of MMP-9 in spinal cords associated with multiple sclerosis and urological neuroanatomy
14) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.58 Pain Relevance 0.16
Exposure to 12 days of immobilisation stress induces a consistent increase in PGE2, MMP-9 over-expression and increased EAE clinical score.
Positive_regulation (induces) of Gene_expression (over) of MMP-9 associated with stress and multiple sclerosis
15) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.64 Pain Relevance 0.23
Exposure to 12 days of immobilisation stress induces a consistent increase in PGE2, MMP-9 over-expression and increased EAE clinical score.
Positive_regulation (increase) of Gene_expression (over) of MMP-9 associated with stress and multiple sclerosis
16) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.57 Pain Relevance 0.23
At day 12, MMP-9 expression was higher in the EAE+S group compared to the EAE group (figure 5C: F:405,1, dF:7), suggesting that stress could be enhancing EAE-induced BBB dysfunction, in contrast to what was observed on day 21.
Positive_regulation (higher) of Gene_expression (expression) of MMP-9 associated with stress and multiple sclerosis
17) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.56 Pain Relevance 0.15
Exposure to 12 days of immobilisation stress induces a consistent increase in PGE2, MMP-9 over-expression and increased EAE clinical score.
Positive_regulation (induces) of Gene_expression (expression) of MMP-9 associated with stress and multiple sclerosis
18) Confidence 0.20 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.64 Pain Relevance 0.23
Chung et al. (2001) [37] showed that ectopic endometrium expressed significantly higher levels of MMP-9 mRNA and lower levels of TIMP-3 mRNA, compared to eutopic endometrium from normal and endometriosis patients.
Positive_regulation (levels) of Gene_expression (levels) of MMP-9 mRNA in endometrium associated with endometriosis
19) Confidence 0.20 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2826344 Disease Relevance 1.17 Pain Relevance 0.31
Expression of the myofibroblastic marker alpha-smooth muscle actin, connective tissue growth factor, and ET-1 itself in PSC was reduced, while expression of matrix metalloproteinase-9 was enhanced.
Positive_regulation (enhanced) of Gene_expression (expression) of matrix metalloproteinase-9 in PSC associated with primary sclerosing cholangitis and metalloproteinase
20) Confidence 0.20 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18612819 Disease Relevance 1.29 Pain Relevance 0.30

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