INT68999

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Context Info
Confidence 0.35
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (FOSL1) nucleus (FOSL1)
FOSL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 33 99.64 Very High Very High Very High
antagonist 6 89.68 High High
Neuropeptide 3 88.24 High High
Opioid 3 87.72 High High
Dopamine 3 84.92 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, DYN peptide and mRNA levels, as well as Fos/FRA proteins and AP-1 DNA binding activity, were measured in individual animals following acute challenge with the psychostimulant drug methamphetamine (METH).
FRA Binding (binding) of associated with dynorphin
1) Confidence 0.35 Published 1996 Journal Biol. Signals Section Abstract Doc Link 9116798 Disease Relevance 0 Pain Relevance 0.51
Analyses of the time course of METH's effects revealed that DYN mRNA levels, Fos/FRA proteins and AP-1 binding activity showed variable increases by 3 h but all were significantly elevated above control levels by 6 h posttreatment.
FRA Binding (activity) of associated with dynorphin
2) Confidence 0.35 Published 1996 Journal Biol. Signals Section Abstract Doc Link 9116798 Disease Relevance 0 Pain Relevance 0.62
In this study, DYN peptide and mRNA levels, as well as Fos/FRA proteins and AP-1 DNA binding activity, were measured in individual animals following acute challenge with the psychostimulant drug methamphetamine (METH).
FRA Binding (activity) of associated with dynorphin
3) Confidence 0.35 Published 1996 Journal Biol. Signals Section Abstract Doc Link 9116798 Disease Relevance 0 Pain Relevance 0.51

General Comments

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